Rojas, S.; Gispert, JD.; Martín González, R.; Abad, S.; Menchón, C.; Pareto, D.; Víctor, VM.... (2011). Biodistribution of Amino-Functionalized Diamond Nanoparticles. In Vivo Studies Based on (18)F Radionuclide Emission. ACS Nano. 5(7):5552-5559. https://doi.org/10.1021/nn200986z
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/27991
Título:
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Biodistribution of Amino-Functionalized Diamond Nanoparticles. In Vivo Studies Based on (18)F Radionuclide Emission
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Autor:
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Rojas, Santiago
Gispert, Juan D.
Martín González, Roberto
Abad, Sergio
Menchón, Cristina
Pareto, Deborah
Víctor, Víctor M.
Alvaro Rodríguez, Maria Mercedes
García Gómez, Hermenegildo
Herance, J. Raúl
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Entidad UPV:
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Universitat Politècnica de València. Departamento de Química - Departament de Química
Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química
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Fecha difusión:
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Resumen:
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[EN] Nanoparticles have been proposed for several biomedical applications; however,
in vivo biodistribution studies to con¿rm their potential are scarce. Nanodiamonds are carbon
nanoparticles that have been recently ...[+]
[EN] Nanoparticles have been proposed for several biomedical applications; however,
in vivo biodistribution studies to con¿rm their potential are scarce. Nanodiamonds are carbon
nanoparticles that have been recently proposed as a promising biomaterial. In this study, we labeled
nanodiamonds with 18F to study their in vivo biodistribution by positron emission tomography.
Moreover, the impact on the biodistribution of their kinetic particle size and of the surfactant agents
has been evaluated. Radiolabeled diamond nanoparticles accumulated mainly in the lung, spleen,
and liver and were excreted into the urinary tract. The addition of surfactant agents did not lead to
signi¿cant changes in this pattern, with the exception of a slight reduction in the urinary excretion
rate. On the other hand, after ¿ltration of the radiolabeled diamond nanoparticles to remove those
with a larger kinetic size, the uptake in the lung and spleen was completely inhibited and
signi¿cantly reduced in the liver
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Palabras clave:
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Nanodiamonds
,
PET
,
Pharmacokinetics
,
In vivo evaluation
,
Rodent
,
Surfactant
,
Fltration
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Derechos de uso:
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Cerrado |
Fuente:
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ACS Nano. (issn:
1936-0851
)
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DOI:
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10.1021/nn200986z
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Editorial:
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American Chemical Society
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Versión del editor:
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http://dx.doi.org/10.1021/nn200986z
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Código del Proyecto:
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info:eu-repo/grantAgreement/MICINN//PS09%2F02620/ES/ESTUDIO PET DE LOS PROCESOS FISIOPATOLOGICOS IMPLICADOS EN LA MUERTE NEURONAL SECUNDARIA EN LA HEMORRAGIA INTRAPARENQUIMATOSA Y LA ISQUEMIA CEREBRAL FOCAL/
MICINN/CTQ-2009-11586
...[+]
info:eu-repo/grantAgreement/MICINN//PS09%2F02620/ES/ESTUDIO PET DE LOS PROCESOS FISIOPATOLOGICOS IMPLICADOS EN LA MUERTE NEURONAL SECUNDARIA EN LA HEMORRAGIA INTRAPARENQUIMATOSA Y LA ISQUEMIA CEREBRAL FOCAL/
info:eu-repo/grantAgreement/ISCIII//PI10%2F1195/
info:eu-repo/grantAgreement/MICINN//PS09%2F02217/ES/VALORACION DEL POTENCIAL TERAPEUTICO DEL EVEROLIMUS EN UN MODELO DE ESCLEROSIS MULTIPLE. ESTUDIO MEDIANTE TOMOGRAFIA POR EMISION DE POSITRONES/
info:eu-repo/grantAgreement/ISCIII//CES10%2F030/
info:eu-repo/grantAgreement/Fundació La Marató de TV3//090530/
MICINN/CTQ-2009-11586
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Agradecimientos:
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The present work was supported by Spanish MICINN (Grant CTQ-2009-11586); the Fondo de Investigacion Sanitaria (FIS) of the Instituto de Salud Carlos III (Grants PS09/02620, PI10/1195, and PS09/02217), La Marato TV3 Foundation ...[+]
The present work was supported by Spanish MICINN (Grant CTQ-2009-11586); the Fondo de Investigacion Sanitaria (FIS) of the Instituto de Salud Carlos III (Grants PS09/02620, PI10/1195, and PS09/02217), La Marato TV3 Foundation (Grant 090530), and CDTI under the CENIT Programme (AMIT Project) and supported by the Spanish Ministry of Science and Innovation. R.M. thanks the Spanish Ministry for a postgraduate scholarship. V.M.V. is a recipient of Fond de Investigacion Sanitaria (FIS) and Generalitat Valenciana contract (CES10/030)
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Tipo:
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Artículo
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