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Enantioselective Synthesis of 4-Substituted Dihydrocoumarins through a Zinc Bis(hydroxyamide)-Catalyzed Conjugate Addition of Terminal Alkynes

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Enantioselective Synthesis of 4-Substituted Dihydrocoumarins through a Zinc Bis(hydroxyamide)-Catalyzed Conjugate Addition of Terminal Alkynes

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dc.contributor.author Blay, Gonzalo es_ES
dc.contributor.author Muñoz Roca, María del Carmen es_ES
dc.contributor.author Pedro, Jose R es_ES
dc.contributor.author Sanz-Marco, Amparo es_ES
dc.date.accessioned 2013-11-22T07:42:32Z
dc.date.issued 2013-04-15
dc.identifier.issn 1615-4150
dc.identifier.uri http://hdl.handle.net/10251/33920
dc.description.abstract A new enantioselective catalyst for the conjugate addition of terminal alkynes has been developed. Terminal alkynes react with 3-alkoxycarbonylcoumarins in the presence of diethylzinc and bis(hydroxyamide) ligands to give chiral non-racemic dihydrocoumarins substituted with an alkynyl group on the C-4 position with good yields and enantiomeric excesses up to 95%. es_ES
dc.description.sponsorship Financial support from the Ministerio de Economia y Competitividad (Gobierno de Espana) and FEDER (European Union) (CTQ2009-13083) and from Generalitat Valenciana (ACOMP2012-212 and ISIC2012/001) is gratefully acknowledged. A. S.-M. thanks the MEC for a pre-doctoral grant (FPI). en_EN
dc.format.extent 6 es_ES
dc.language Inglés es_ES
dc.publisher Wiley-VCH Verlag es_ES
dc.relation.ispartof Advanced Synthesis and Catalysis es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Alkynylation es_ES
dc.subject Asymmetric catalysis es_ES
dc.subject Nucleophilic addition es_ES
dc.subject Oxygen heterocycles es_ES
dc.subject N, O ligands es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Enantioselective Synthesis of 4-Substituted Dihydrocoumarins through a Zinc Bis(hydroxyamide)-Catalyzed Conjugate Addition of Terminal Alkynes es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1002/adsc.201201120
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//CTQ2009-13083/ES/Desarrollo de nuevos procesos enantioselectivos de formación de enlaces C-C mediante catálisis asimétrica/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//ISIC2012%2F001/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//ACOMP%2F2012%2F212/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.description.bibliographicCitation Blay, G.; Muñoz Roca, MDC.; Pedro, JR.; Sanz-Marco, A. (2013). Enantioselective Synthesis of 4-Substituted Dihydrocoumarins through a Zinc Bis(hydroxyamide)-Catalyzed Conjugate Addition of Terminal Alkynes. Advanced Synthesis and Catalysis. 355:1071-1076. https://doi.org/10.1002/adsc.201201120 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1002/adsc.201201120 es_ES
dc.description.upvformatpinicio 1071 es_ES
dc.description.upvformatpfin 1076 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 355 es_ES
dc.relation.senia 246053
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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