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Amidase-responsive controlled release of antitumoral drug into intracellular media using gluconamide-capped mesoporous silica nanoparticles

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Amidase-responsive controlled release of antitumoral drug into intracellular media using gluconamide-capped mesoporous silica nanoparticles

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Candel Busquets, I.; Aznar Gimeno, E.; Mondragón Martínez, L.; De La Torre Paredes, C.; Martínez Mañez, R.; Sancenón Galarza, F.; Marcos Martínez, MD.... (2012). Amidase-responsive controlled release of antitumoral drug into intracellular media using gluconamide-capped mesoporous silica nanoparticles. Nanoscale. 4(22):7237-7245. doi:10.1039/c2nr32062b

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/37356

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Title: Amidase-responsive controlled release of antitumoral drug into intracellular media using gluconamide-capped mesoporous silica nanoparticles
Author: Candel Busquets, Inmaculada Aznar Gimeno, Elena Mondragón Martínez, Laura De la Torre Paredes, Cristina Martínez Mañez, Ramón Sancenón Galarza, Félix Marcos Martínez, María Dolores Amoros del Toro, Pedro Jose Guillem, Carmen Pérez Payá, Enrique Costero Nieto, Ana María Gil Grau, Salvador Parra Álvarez, Margarita
UPV Unit: Universitat Politècnica de València. Departamento de Química - Departament de Química
Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic
Issued date:
Abstract:
MCM-41 silica nanoparticles were used as inorganic scaffolding to prepare a nanoscopic-capped hybrid material S1, which was able to release an entrapped cargo in the presence of certain enzymes, whereas in the absence of ...[+]
Subjects: Amidohydrolases , Antineoplastic Agents , Camptothecin , Cell Survival , Drug effects , Gluconates , HeLa Cells , Hydrogen Bonding , Lysosomes , MCF-7 Cells , Nanoparticles , Porosity , Silicon Dioxide , Electron Microscopy Service of the UPV
Copyrigths: Reserva de todos los derechos
Source:
Nanoscale. (issn: 2040-3364 )
DOI: 10.1039/c2nr32062b
Publisher:
Royal Society of Chemistry
Publisher version: http://dx.doi.org/10.1039/c2nr32062b
Thanks:
We thank the Spanish Government (Project MAT2009-14564-C04 and SAF2010-15512) and the Generalitat Valenciana (Project PROMETEO/2009/016and/2010/005) for support. I. C. thanks the Universitat Politecnica de Valencia for her ...[+]
Type: Artículo

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