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Amidase-responsive controlled release of antitumoral drug into intracellular media using gluconamide-capped mesoporous silica nanoparticles

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Amidase-responsive controlled release of antitumoral drug into intracellular media using gluconamide-capped mesoporous silica nanoparticles

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Candel Busquets, I.; Aznar Gimeno, E.; Mondragón Martínez, L.; De La Torre Paredes, C.; Martínez Mañez, R.; Sancenón Galarza, F.; Marcos Martínez, MD.... (2012). Amidase-responsive controlled release of antitumoral drug into intracellular media using gluconamide-capped mesoporous silica nanoparticles. Nanoscale. 4(22):7237-7245. doi:10.1039/c2nr32062b

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/37356

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Title: Amidase-responsive controlled release of antitumoral drug into intracellular media using gluconamide-capped mesoporous silica nanoparticles
Author:
UPV Unit: Universitat Politècnica de València. Departamento de Química - Departament de Química
Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic
Issued date:
Abstract:
MCM-41 silica nanoparticles were used as inorganic scaffolding to prepare a nanoscopic-capped hybrid material S1, which was able to release an entrapped cargo in the presence of certain enzymes, whereas in the absence of ...[+]
Subjects: Amidohydrolases , Antineoplastic Agents , Camptothecin , Cell Survival , Drug effects , Gluconates , HeLa Cells , Hydrogen Bonding , Lysosomes , MCF-7 Cells , Nanoparticles , Porosity , Silicon Dioxide , Electron Microscopy Service of the UPV
Copyrigths: Reserva de todos los derechos
Source:
Nanoscale. (issn: 2040-3364 )
DOI: 10.1039/c2nr32062b
Publisher:
Royal Society of Chemistry
Publisher version: http://dx.doi.org/10.1039/c2nr32062b
Thanks:
We thank the Spanish Government (Project MAT2009-14564-C04 and SAF2010-15512) and the Generalitat Valenciana (Project PROMETEO/2009/016and/2010/005) for support. I. C. thanks the Universitat Politecnica de Valencia for her ...[+]
Type: Artículo

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