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Electrical pumping of potassium ions against an external concentration gradient in a biological ion channel

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Electrical pumping of potassium ions against an external concentration gradient in a biological ion channel

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dc.contributor.author Queralt-Martín, María es_ES
dc.contributor.author García Giménez, Elena es_ES
dc.contributor.author Aguilella, Vicente-Manuel es_ES
dc.contributor.author Ramirez Hoyos, Patricio es_ES
dc.contributor.author Mafé, Salvador es_ES
dc.contributor.author Alcaraz González, Antonio es_ES
dc.date.accessioned 2014-06-24T12:58:45Z
dc.date.issued 2013-07
dc.identifier.issn 0003-6951
dc.identifier.uri http://hdl.handle.net/10251/38330
dc.description.abstract We show experimentally and theoretically that significant currents can be obtained with a biological ion channel, the OmpF porin of Escherichia coli, using zero-average potentials as driving forces. The channel rectifying properties can be used to pump potassium ions against an external concentration gradient under asymmetric pH conditions. The results are discussed in terms of the ionic selectivity and rectification ratio of the channel. The physical concepts involved may be applied to separation processes with synthetic nanopores and to bioelectrical phenomena. (C) 2013 AIP Publishing LLC. es_ES
dc.description.sponsorship The authors acknowledge Marcel Aguilella-Arzo and Vicente Gomez for assistance in the preparation of the artwork. Financial support from the Generalitat Valenciana (Project PROMETEO/GV/0069), the Ministry of Economy and Competitiveness of Spain (Project Nos. FIS2010-19810 and MAT2012-32084), Fundacio Caixa Castello-Bancaixa (Project No. P1-1B2012-03), and FEDER is also acknowledged. en_EN
dc.language Inglés es_ES
dc.publisher American Institute of Physics (AIP) es_ES
dc.relation Generalitat Valenciana (Project PROMETEO/GV/0069) es_ES
dc.relation Ministry of Economy and Competitiveness of Spain (Project Nos. FIS2010-19810 and MAT2012-32084) es_ES
dc.relation Fundació Caixa Castelló-Bancaixa (Project No. P1-1B2012-03) es_ES
dc.relation.ispartof Applied Physics Letters es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject RATCHET es_ES
dc.subject NANOFLUIDIC DIODE es_ES
dc.subject SELECTIVITY es_ES
dc.subject RECTIFICATION es_ES
dc.subject NANOPORES es_ES
dc.subject PORIN es_ES
dc.subject OMPF es_ES
dc.subject VOLTAGE es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Electrical pumping of potassium ions against an external concentration gradient in a biological ion channel es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1063/1.4816748
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.description.bibliographicCitation Queralt-Martín, M.; García Giménez, E.; Aguilella, V.; Ramirez Hoyos, P.; Mafé, S.; Alcaraz González, A. (2013). Electrical pumping of potassium ions against an external concentration gradient in a biological ion channel. Applied Physics Letters. 103:43707-43711. doi:10.1063/1.4816748 es_ES
dc.description.accrualMethod Senia es_ES
dc.relation.publisherversion http://dx.doi.org/10.1063/1.4816748 es_ES
dc.description.upvformatpinicio 43707 es_ES
dc.description.upvformatpfin 43711 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 103 es_ES
dc.relation.senia 255514


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