Fares Riaño, MA.; Keane, O.; Toft, C.; Carretero Paulet, L.; Jones, G. (2013). The roles of whole-genome and small-scale duplications in the functional specialization of Saccharomyces cerevisiae genes. PLoS Genetics. 9(1):1003176-1003176. doi:10.1371/journal.pgen.1003176
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/38839
Title:
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The roles of whole-genome and small-scale duplications in the functional specialization of Saccharomyces cerevisiae genes
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Author:
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Fares Riaño, Mario Ali
Keane, O.
Toft, C.
Carretero Paulet, Lorenzo
Jones, G.W.
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UPV Unit:
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Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes
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Issued date:
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Abstract:
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[EN] Researchers have long been enthralled with the idea that gene duplication can generate novel functions, crediting this process with great evolutionary importance. Empirical data shows that whole-genome duplications ...[+]
[EN] Researchers have long been enthralled with the idea that gene duplication can generate novel functions, crediting this process with great evolutionary importance. Empirical data shows that whole-genome duplications (WGDs) are more likely to be retained than small-scale duplications (SSDs), though their relative contribution to the functional fate of duplicates remains unexplored. Using the map of genetic interactions and the re-sequencing of 27 Saccharomyces cerevisiae genomes evolving for 2,200 generations we show that SSD-duplicates lead to neo-functionalization while WGD-duplicates partition ancestral functions. This conclusion is supported by: (a) SSD-duplicates establish more genetic interactions than singletons and WGD-duplicates; (b) SSD-duplicates copies share more interaction-partners than WGD-duplicates copies; (c) WGD-duplicates interaction partners are more functionally related than SSD-duplicates partners; (d) SSD-duplicates gene copies are more functionally divergent from one another, while keeping more overlapping functions, and diverge in their subcellular locations more than WGD-duplicates copies; and (e) SSD-duplicates complement their functions to a greater extent than WGD-duplicates. We propose a novel model that uncovers the complexity of evolution after gene duplication.
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Subjects:
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Protein-Protein interactions
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Mads-Box genes
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Molecular evolution
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Interactions reveal
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Adaptive conflict
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Null mutations
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Yeast genome
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Divergence
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Diversification
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Arabidopsis
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Copyrigths:
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Reconocimiento (by)
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Source:
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PLoS Genetics. (issn:
1553-7390
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DOI:
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10.1371/journal.pgen.1003176
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Publisher:
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Public Library of Science
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Publisher version:
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http://dx.doi.org/10.1371/journal.pgen.1003176
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Project ID:
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SFI/04/YI1/M518
SFI/10/RFP/GEN2685
MICINN/BFU2009-12022
EMBO/EMBO ALTF 730-2011
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Thanks:
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This study was supported by Science Foundation Ireland grants to MAF under two programs: the President of Ireland Young Researcher Award (04/YI1/M518) and the Research Frontiers Program (10/RFP/GEN2685). The study of ...[+]
This study was supported by Science Foundation Ireland grants to MAF under two programs: the President of Ireland Young Researcher Award (04/YI1/M518) and the Research Frontiers Program (10/RFP/GEN2685). The study of distribution of mutations in duplicates and their possible effects on fitness was supported by a grant from the Ministerio de Ciencia e Innovacion (BFU2009-12022) to MAF. CT is supported by a long-term postdoctoral EMBO fellowship (EMBO ALTF 730-2011). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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Type:
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Artículo
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