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dc.contributor.author | Fares Riaño, Mario Ali | es_ES |
dc.contributor.author | Keane, O. | es_ES |
dc.contributor.author | Toft, C. | es_ES |
dc.contributor.author | Carretero Paulet, Lorenzo | es_ES |
dc.contributor.author | Jones, G.W. | es_ES |
dc.date.accessioned | 2014-07-16T08:46:33Z | |
dc.date.available | 2014-07-16T08:46:33Z | |
dc.date.issued | 2013-01 | |
dc.identifier.issn | 1553-7390 | |
dc.identifier.uri | http://hdl.handle.net/10251/38839 | |
dc.description.abstract | [EN] Researchers have long been enthralled with the idea that gene duplication can generate novel functions, crediting this process with great evolutionary importance. Empirical data shows that whole-genome duplications (WGDs) are more likely to be retained than small-scale duplications (SSDs), though their relative contribution to the functional fate of duplicates remains unexplored. Using the map of genetic interactions and the re-sequencing of 27 Saccharomyces cerevisiae genomes evolving for 2,200 generations we show that SSD-duplicates lead to neo-functionalization while WGD-duplicates partition ancestral functions. This conclusion is supported by: (a) SSD-duplicates establish more genetic interactions than singletons and WGD-duplicates; (b) SSD-duplicates copies share more interaction-partners than WGD-duplicates copies; (c) WGD-duplicates interaction partners are more functionally related than SSD-duplicates partners; (d) SSD-duplicates gene copies are more functionally divergent from one another, while keeping more overlapping functions, and diverge in their subcellular locations more than WGD-duplicates copies; and (e) SSD-duplicates complement their functions to a greater extent than WGD-duplicates. We propose a novel model that uncovers the complexity of evolution after gene duplication. | es_ES |
dc.description.sponsorship | This study was supported by Science Foundation Ireland grants to MAF under two programs: the President of Ireland Young Researcher Award (04/YI1/M518) and the Research Frontiers Program (10/RFP/GEN2685). The study of distribution of mutations in duplicates and their possible effects on fitness was supported by a grant from the Ministerio de Ciencia e Innovacion (BFU2009-12022) to MAF. CT is supported by a long-term postdoctoral EMBO fellowship (EMBO ALTF 730-2011). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | |
dc.language | Inglés | es_ES |
dc.publisher | Public Library of Science | es_ES |
dc.relation.ispartof | PLoS Genetics | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.subject | Protein-Protein interactions | es_ES |
dc.subject | Mads-Box genes | es_ES |
dc.subject | Molecular evolution | es_ES |
dc.subject | Interactions reveal | es_ES |
dc.subject | Adaptive conflict | es_ES |
dc.subject | Null mutations | es_ES |
dc.subject | Yeast genome | es_ES |
dc.subject | Divergence | es_ES |
dc.subject | Diversification | es_ES |
dc.subject | Arabidopsis | es_ES |
dc.title | The roles of whole-genome and small-scale duplications in the functional specialization of Saccharomyces cerevisiae genes | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1371/journal.pgen.1003176 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//BFU2009-12022/ES/Impacto De La Duplicacion Genomica En La Innovacion Y Geometria Funcional De Arabidopsis Thaliana/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/SFI/SFI Research Frontiers Programme (RFP)/10%2FRFP%2FGEN2685/IE/Understanding the Role of Heat-Shock Proteins in Evolutionary Innovation/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/EMBO//ALTF 730-2011/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/SFI/SFI President of Ireland Young Resercher Award (PIYRA)/04%2FYI.1%2FM518/IE/Computational and biomedical analysis of heat shock proteins (Hsps): optimisation of protein function and putative drug targets/ | |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes | es_ES |
dc.description.bibliographicCitation | Fares Riaño, MA.; Keane, O.; Toft, C.; Carretero Paulet, L.; Jones, G. (2013). The roles of whole-genome and small-scale duplications in the functional specialization of Saccharomyces cerevisiae genes. PLoS Genetics. 9(1):1003176-1003176. https://doi.org/10.1371/journal.pgen.1003176 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1371/journal.pgen.1003176 | es_ES |
dc.description.upvformatpinicio | 1003176 | es_ES |
dc.description.upvformatpfin | 1003176 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 9 | es_ES |
dc.description.issue | 1 | es_ES |
dc.relation.senia | 259319 | |
dc.identifier.pmid | 23300483 | en_EN |
dc.identifier.pmcid | PMC3536658 | en_EN |
dc.contributor.funder | Science Foundation Ireland | |
dc.contributor.funder | Ministerio de Ciencia e Innovación | |
dc.contributor.funder | European Molecular Biology Organization |