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Non-Uniform Dispersion of the Source-Sink Relationship Alters Wavefront Curvature

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Non-Uniform Dispersion of the Source-Sink Relationship Alters Wavefront Curvature

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dc.contributor.author Romero Pérez, Lucia es_ES
dc.contributor.author Trénor Gomis, Beatriz Ana es_ES
dc.contributor.author Ferrero De Loma-Osorio, José María es_ES
dc.contributor.author Starmer, C. Frank es_ES
dc.date.accessioned 2014-08-29T10:43:04Z
dc.date.available 2014-08-29T10:43:04Z
dc.date.issued 2013-11
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10251/39288
dc.description.abstract The distribution of cellular source-sink relationships plays an important role in cardiac propagation. It can lead to conduction slowing and block as well as wave fractionation. It is of great interest to unravel the mechanisms underlying evolution in wavefront geometry. Our goal is to investigate the role of the source-sink relationship on wavefront geometry using computer simulations. We analyzed the role of variability in the microscopic source-sink relationship in driving changes in wavefront geometry. The electrophysiological activity of a homogeneous isotropic tissue was simulated using the ten Tusscher and Panfilov 2006 action potential model and the source-sink relationship was characterized using an improved version of the Romero et al. safety factor formulation (SFm2). Our simulations reveal that non-uniform dispersion of the cellular source-sink relationship (dispersion along the wavefront) leads to alterations in curvature. To better understand the role of the source-sink relationship in the process of wave formation, the electrophysiological activity at the initiation of excitation waves in a 1D strand was examined and the source-sink relationship was characterized using the two recently updated safety factor formulations: the SFm2 and the Boyle-Vigmond (SFVB) definitions. The electrophysiological activity at the initiation of excitation waves was intimately related to the SFm2 profiles, while the SFVB led to several counterintuitive observations. Importantly, with the SFm2 characterization, a critical source-sink relationship for initiation of excitation waves was identified, which was independent of the size of the electrode of excitation, membrane excitability, or tissue conductivity. In conclusion, our work suggests that non-uniform dispersion of the source-sink relationship alters wavefront curvature and a critical source-sink relationship profile separates wave expansion from collapse. Our study reinforces the idea that the safety factor represents a powerful tool to study the mechanisms of cardiac propagation in silico, providing a better understanding of cardiac arrhythmias and their therapy. es_ES
dc.description.sponsorship This work was partially supported by the "VI Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica'' from the Ministerio de Economia y Competitividad of Spain (TIN2012?37546?C03?01) and the European Commission (European Regional Development Funds - ERDF ? FEDER), Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica, Plan Avanza en el marco de la Accion Estrategica de Telecomunicaciones y Sociedad de la Informacion del Ministerio de Industria Turismo y Comercio of Spain (TSI?020100?2010?469), Programa de Apoyo a la Investigacion y Desarrollo (PAID?06?11?2002) de la Universidad Politecnica de Valencia, Direccion General de Politica Cientifica de la Generalitat Valenciana (GV/2013/119) and Programa Prometeo (PROMETEO/2012/030) de la Conselleria d'Educacio Formacio I Ocupacio, Generalitat Valenciana. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. en_EN
dc.language Inglés es_ES
dc.publisher Public Library of Science es_ES
dc.relation.ispartof PLoS ONE es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Action-potential propagation es_ES
dc.subject Cardiac tissue es_ES
dc.subject Safety factor es_ES
dc.subject Vulnerable period es_ES
dc.subject Slow conduction es_ES
dc.subject Muscle es_ES
dc.subject Excitability es_ES
dc.subject Model es_ES
dc.subject Arrhythmias es_ES
dc.subject Fibrillation es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Non-Uniform Dispersion of the Source-Sink Relationship Alters Wavefront Curvature es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1371/journal.pone.0078328
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//TIN2012-37546-C03-01/ES/CORAZON HUMANO COMPLETO FISIOLOGICO VIRTUAL: MEJORAS EN EL TRATAMIENTO DE ARRITMIAS CARDIACAS ORIENTADO A PACIENTE/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MITURCO//TSI-020100-2010-0469/ES/LocMoTIC. Localización del Origen de Arritmias Cardíacas Mediante Modelado y Tecnologías de la Información y Comunicaciones/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UPV//PAID-06-11-2002/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//GV%2F2013%2F119/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2012%2F030/ES/MEJORA EN LA PREVENCION Y TRATAMIENTO DE PATOLOGIAS CARDIACAS A TRAVES DE LA MODELIZACION MULTI-ESCALA Y LA SIMULACION COMPUTACIONAL (DIGITAL HEART)/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà es_ES
dc.description.bibliographicCitation Romero Pérez, L.; Trénor Gomis, BA.; Ferrero De Loma-Osorio, JM.; Starmer, CF. (2013). Non-Uniform Dispersion of the Source-Sink Relationship Alters Wavefront Curvature. PLoS ONE. 1-12. https://doi.org/10.1371/journal.pone.0078328 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1371/journal.pone.0078328 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 12 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.relation.senia 254374
dc.identifier.pmid 24223791 en_EN
dc.identifier.pmcid PMC3817246 en_EN
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Industria, Turismo y Comercio es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder European Regional Development Fund es_ES
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