González Suárez, A.; Trujillo Guillen, M.; Burdío Pinilla, F.; Andaluz Martínez, AM.; Berjano Zanón, E. (2012). Feasibility study of an internally cooled bipolar applicator for RF coagulation of hepatic tissue: Experimental and computational study. International Journal of Hyperthermia. 28(7):663-673. doi:10.3109/02656736.2012.716900
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/40730
Title:
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Feasibility study of an internally cooled bipolar applicator for RF coagulation of hepatic tissue: Experimental and computational study
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Author:
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González Suárez, Ana
Trujillo Guillen, Macarena
Burdío Pinilla, Fernando
Andaluz Martínez, Ana María
Berjano Zanón, Enrique
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UPV Unit:
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Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica
Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada
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Issued date:
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Abstract:
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Purpose: To study the capacity of an internally cooled radiofrequency (RF) bipolar applicator to create sufficiently deep thermal lesions in hepatic tissue. Materials and methods: Three complementary methodologies were ...[+]
Purpose: To study the capacity of an internally cooled radiofrequency (RF) bipolar applicator to create sufficiently deep thermal lesions in hepatic tissue. Materials and methods: Three complementary methodologies were employed to check the electrical and thermal behaviour of the applicator under test. The experimental studies were based on excised bovine (ex vivo study) and porcine liver (in vivo study) and the theoretical models were solved by means of the finite element method (FEM). Results: Experimental and computational results showed good agreement in terms of impedance progress and lesion depth (4 and 4.5 mm respectively for ex vivo conditions, and approximately 7 and 9 mm respectively for in vivo conditions), although the lesion widths were overestimated by the computer simulations. This could have been due to the method used to assess the thermal lesions; the experimental lesions were assessed by the white coagulation zone, whereas the tissue damage function was used to assess the computational lesions. Conclusions: The experimental results suggest that this applicator could create in vivo lesions to a depth of around 7mm. It was also observed that the thermal lesion is mainly confined to the area between both electrodes, which would allow lesion width to be controlled by selecting a specific applicator design. The comparison between the experimental and computational results suggests that the theoretical model could be usefully applied in further studies of the performance of this device. © 2012 Informa UK Ltd All rights reserved.
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Subjects:
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Experimental model
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Finite element method
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Hepatic resection
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Internally cooled bipolar electrode
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Radiofrequency ablation
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Animal experiment
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Animal tissue
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Blood clotting
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Controlled study
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Electric conductivity
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Electrode
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In vivo study
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Ex vivo study
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Experimental study
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Feasibility study
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Finite element analysis
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Impedance
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Liver
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Nonhuman
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Radiation applicator
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Radiofrequency
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Radiofrequency radiation
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Simulation
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Thermal injury
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Tissue injury
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Copyrigths:
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Reserva de todos los derechos
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Source:
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International Journal of Hyperthermia. (issn:
0265-6736
)
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DOI:
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10.3109/02656736.2012.716900
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Publisher:
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Informa Healthcare
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Publisher version:
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http://dx.doi.org/10.3109/02656736.2012.716900
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Thanks:
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This work received financial support from the Spanish Plan Nacional de I+D+I del Ministerio de Ciencia e Innovacion TEC2011-27133-C02-(01 and 02), from Universitat Politecnica de Valencia (INNOVA11-01-5502; and PAID-06-11 ...[+]
This work received financial support from the Spanish Plan Nacional de I+D+I del Ministerio de Ciencia e Innovacion TEC2011-27133-C02-(01 and 02), from Universitat Politecnica de Valencia (INNOVA11-01-5502; and PAID-06-11 Ref. 1988). A. Gonzalez-Suarez is the recipient of grant VaLi+D (ACIF/2011/194) from the Generalitat Valenciana. The proof-reading of this paper was funded by the Universitat Politecnica de Valencia, Spain. The authors alone are responsible for the content and writing of the paper.
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Type:
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Artículo
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