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New concept for a regenerative and resorbable prosthesis for tendon and ligament. Physicochemical and biological characterization of PLA-braided biomaterial

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New concept for a regenerative and resorbable prosthesis for tendon and ligament. Physicochemical and biological characterization of PLA-braided biomaterial

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dc.contributor.author Araque Monrós, María Carmen es_ES
dc.contributor.author Gamboa Martínez, Tatiana Carolina es_ES
dc.contributor.author Gil Santos, Luis es_ES
dc.contributor.author Gironés Bernabé, Sagrario es_ES
dc.contributor.author Monleón Pradas, Manuel es_ES
dc.contributor.author Más Estellés, Jorge es_ES
dc.date.accessioned 2014-10-15T07:08:24Z
dc.date.available 2014-10-15T07:08:24Z
dc.date.issued 2013-11
dc.identifier.issn 1549-3296
dc.identifier.uri http://hdl.handle.net/10251/43271
dc.description.abstract We present a concept for a new regenerative and resorbable prosthesis for tendon and ligament and characterize the physicomechanical and biological behavior of one of its components, a hollow braid made of poly-lactide acid (PLA) which is the load-bearing part of the prosthesis concept. The prosthesis consists of a braid, microparticles in its interior serving as cell carriers, and a surface non-adherent coating, all these parts being made of biodegradable materials. The PLA braid has a nonlinear convex stress-strain behavior with a Young modulus of 1370 +/- 90 MPa in the linear, stretched state, and after 12 months of hydrolytic degradation the modulus shows a reduction by a factor of four. Different disinfection methods were tested as to their efficiency in cleansing the braid and preparing it for cell culture. Fibroblasts of L929 line were grown on the PLA braid for 14 days, showing good adherence and proliferation. These studies validate the PLA braid for the intended purpose in the regenerative prosthesis concept. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 3228-3237, 2013 es_ES
dc.description.sponsorship This work has been developed thanks to the financial support of AITEX (Valencia, Spain). JME thanks Drs. Isabel Pascual, Andres Pena, and their team from Hospital Clinico of Valencia for their fine work. en_EN
dc.language Inglés es_ES
dc.publisher Wiley es_ES
dc.relation.ispartof Journal of Biomedical Materials Research Part A es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Prosthesis es_ES
dc.subject Tendon es_ES
dc.subject Ligament es_ES
dc.subject Resorbable es_ES
dc.subject Regenerative es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title New concept for a regenerative and resorbable prosthesis for tendon and ligament. Physicochemical and biological characterization of PLA-braided biomaterial es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/jbm.a.34633
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular es_ES
dc.description.bibliographicCitation Araque Monrós, MC.; Gamboa Martinez, TC.; Gil Santos, L.; Gironés Bernabé, S.; Monleón Pradas, M.; Más Estellés, J. (2013). New concept for a regenerative and resorbable prosthesis for tendon and ligament. Physicochemical and biological characterization of PLA-braided biomaterial. Journal of Biomedical Materials Research Part A. 101A(11):3228-3237. doi:10.1002/jbm.a.34633 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1002/jbm.a.34633 es_ES
dc.description.upvformatpinicio 3228 es_ES
dc.description.upvformatpfin 3237 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 101A es_ES
dc.description.issue 11 es_ES
dc.relation.senia 242797
dc.contributor.funder Asociación de Investigación de la Industria Textil es_ES
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