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Synthesis of Densely Functionalised 5-Halogen-1,3-oxazin-2-ones byHalogen-Mediated Regioselective Cyclisation of N-Cbz-ProtectedPropargylic Amines: A Combined Experimental and Theoretical Study

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Synthesis of Densely Functionalised 5-Halogen-1,3-oxazin-2-ones byHalogen-Mediated Regioselective Cyclisation of N-Cbz-ProtectedPropargylic Amines: A Combined Experimental and Theoretical Study

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Monleon, A.; Blay, G.; Domingo, LR.; Muñoz Roca, MDC.; Pedro, JR. (2013). Synthesis of Densely Functionalised 5-Halogen-1,3-oxazin-2-ones byHalogen-Mediated Regioselective Cyclisation of N-Cbz-ProtectedPropargylic Amines: A Combined Experimental and Theoretical Study. Chemistry - A European Journal. 19(44):14852-14860. doi:10.1002/chem.201302089

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/44095

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Title: Synthesis of Densely Functionalised 5-Halogen-1,3-oxazin-2-ones byHalogen-Mediated Regioselective Cyclisation of N-Cbz-ProtectedPropargylic Amines: A Combined Experimental and Theoretical Study
Author:
UPV Unit: Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada
Issued date:
Abstract:
A very efficient synthesis of 5-halogen-1,3-oxazin-2-ones has been accomplished by the halocyclisation reaction of chiral nonracemic N-carbobenzyloxy (N-Cbz)-protected propargylic amines by using I-2, Br-2 and Cl-2 as ...[+]
Subjects: Density functional calculations , Halocyclisation , Oxazinones , Propargylic amines , Reaction mechanisms , Regioselectivity
Copyrigths: Cerrado
Source:
Chemistry - A European Journal. (issn: 0947-6539 )
DOI: 10.1002/chem.201302089
Publisher:
Wiley-VCH Verlag
Publisher version: http://dx.doi.org/10.1002/chem.201302089
Thanks:
Financial support from the MINECO (Gobierno de Espana) and FEDER (European Union) (CTQ2009-13083) and from Generalitat Valenciana (ACOMP2012-212 and ISIC2012/001) is gratefully acknowledged. A.M. thanks the Generalitat ...[+]
Type: Artículo

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