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dc.contributor.author | Kahm, Matthias![]() |
es_ES |
dc.contributor.author | Navarrete, Clara![]() |
es_ES |
dc.contributor.author | Llopis Torregrosa, Vicent![]() |
es_ES |
dc.contributor.author | Herrera, Rito![]() |
es_ES |
dc.contributor.author | Barreto, Lina![]() |
es_ES |
dc.contributor.author | Yenush, Lynne![]() |
es_ES |
dc.contributor.author | Ariño, Joaquin![]() |
es_ES |
dc.contributor.author | Ramos, Jose![]() |
es_ES |
dc.contributor.author | Kschischo, Maik![]() |
es_ES |
dc.date.accessioned | 2014-11-25T19:03:03Z | |
dc.date.available | 2014-11-25T19:03:03Z | |
dc.date.issued | 2012-06 | |
dc.identifier.issn | 1553-734X | |
dc.identifier.uri | http://hdl.handle.net/10251/44833 | |
dc.description.abstract | The intrinsic ability of cells to adapt to a wide range of environmental conditions is a fundamental process required for survival. Potassium is the most abundant cation in living cells and is required for essential cellular processes, including the regulation of cell volume, pH and protein synthesis. Yeast cells can grow from low micromolar to molar potassium concentrations and utilize sophisticated control mechanisms to keep the internal potassium concentration in a viable range. We developed a mathematical model for Saccharomyces cerevisiae to explore the complex interplay between biophysical forces and molecular regulation facilitating potassium homeostasis. By using a novel inference method ("the reverse tracking algorithm'') we predicted and then verified experimentally that the main regulators under conditions of potassium starvation are proton fluxes responding to changes of potassium concentrations. In contrast to the prevailing view, we show that regulation of the main potassium transport systems (Trk1,2 and Nha1) in the plasma membrane is not sufficient to achieve homeostasis. | es_ES |
dc.description.sponsorship | Maik Kschischo and Matthias Kahm were supported by BMBF grant 0315786C (SysMo2/Translucent 2). Work in Joaquin Arino laboratory was supported by grants BFU2008-04188-C03-01, BFU2011-30197-C3-01, GEN2006-27748-C2-1-E/SYS (SysMo/Translucent) and EUI2009-04147 (SysMo2/Translucent 2), from the MICINN, Spain. Joaquin Arino was the recipient of an Ajut 2009SGR-1091 and an ICREA Academia Award (Generalitat de Catalunya). Work in Jose Ramos laboratory was supported by grants GEN2006-27748-C2-2-E/SYS (SysMo/Translucent), BFU2008-04188-C03-03 and EUI2009-04153 (SysMo2/Translucent 2), (MICINN, Spain). Work in Lynne Yenush laboratory was supported by grants BFU2008-04188-C03-02, BFU2011-30197-C03-03 (MICINN, Spain) and ACOMP/2011/024 (Generalitat Valenciana). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | Public Library of Science | es_ES |
dc.relation.ispartof | PLoS Computational Biology | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.subject | PLASMA-MEMBRANE ATPASE | es_ES |
dc.subject | SACCHAROMYCES-CEREVISIAE | es_ES |
dc.subject | SALT TOLERANCE | es_ES |
dc.subject | PERFECT ADAPTATION | es_ES |
dc.subject | INTRACELLULAR PH | es_ES |
dc.subject | K+ TRANSPORT | es_ES |
dc.subject | H+-ATPASE | es_ES |
dc.subject | CHANNEL | es_ES |
dc.subject | CELLS | es_ES |
dc.subject | ANTIPORTER | es_ES |
dc.subject.classification | BIOQUIMICA Y BIOLOGIA MOLECULAR | es_ES |
dc.title | Potassium starvation in yeast: mechanisms of homeostasis revealed by mathematical modeling | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1371/journal.pcbi.1002548 | |
dc.relation.projectID | info:eu-repo/grantAgreement/BMBF//0315786C/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MEC//GEN2006-27748-C2-2-E/ES/TRANSLUCENT: Gene interaction networks and models of cation homeostasis in Saccharomyces cerevisiae/ / | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//ACOMP%2F2011%2F024/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//BFU2008-04188-C03-02/ES/RUTAS DE TRANSDUCCION DE SEÑALES EN LA REGULACION DE LA HOMEOSTASIS IONICA/ / | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MEC//GEN2006-27748-C2-1-E/ES/TRANSLUCENT: Gene interaction networks and models of cation homeostasis in Saccharomyces cerevisiae/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//EUI2009-04153/ES/MODELIZACION DE LA HOMEOSTASIS IONICA EN LA LEVADURA SACCHAROMYCES CEREVISIAE (TRANSLUCENT-2)/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//BFU2008-04188-C03-03/ES/REGULACION DE LOS FLUJOS DE CATIONES COMO DETERMINANTES DE TOLERANCIA SALINA EN LEVADURAS/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//BFU2011-30197-C03-03/ES/PAPEL DEL TRAFICO DE PROTEINAS EN LA HOMEOSTASIS DE IONES Y NUTRIENTES EN LEVADURA Y PLANTAS/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//BFU2008-04188-C03-01/ES/VIAS DE TRANSDUCCION DE SEÑAL QUE CONTROLAN LA HOMEOSTASIS DE IONES Y NUTRIENTES EN LEVADURAS/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes | es_ES |
dc.description.bibliographicCitation | Kahm, M.; Navarrete, C.; Llopis Torregrosa, V.; Herrera, R.; Barreto, L.; Yenush, L.; Ariño, J.... (2012). Potassium starvation in yeast: mechanisms of homeostasis revealed by mathematical modeling. PLoS Computational Biology. 8(6):1-11. https://doi.org/10.1371/journal.pcbi.1002548 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1371/journal.pcbi.1002548 | es_ES |
dc.description.upvformatpinicio | 1 | es_ES |
dc.description.upvformatpfin | 11 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 8 | es_ES |
dc.description.issue | 6 | es_ES |
dc.relation.senia | 232616 | |
dc.identifier.pmid | 22737060 | en_EN |
dc.identifier.pmcid | PMC3380843 | en_EN |
dc.contributor.funder | Ministerio de Educación y Ciencia | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | Bundesministerium für Bildung und Forschung, Alemania | es_ES |
dc.contributor.funder | Institució Catalana de Recerca i Estudis Avançats | es_ES |
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