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Photosensitization of DNA by 5-methyl-2pyrimidone deoxyribonucleoside: (6-4) photoproduct as a posible trojan horse

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Photosensitization of DNA by 5-methyl-2pyrimidone deoxyribonucleoside: (6-4) photoproduct as a posible trojan horse

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dc.contributor.author Vendrell Criado, Victoria es_ES
dc.contributor.author Rodríguez Muñiz, Gemma María es_ES
dc.contributor.author Cuquerella Alabort, Maria Consuelo es_ES
dc.contributor.author Lhiaubet, Virginie Lyria es_ES
dc.contributor.author Miranda Alonso, Miguel Ángel es_ES
dc.date.accessioned 2015-02-17T11:06:51Z
dc.date.issued 2013-06-17
dc.identifier.issn 1433-7851
dc.identifier.issn 1521-3773
dc.identifier.uri http://hdl.handle.net/10251/47184
dc.description.abstract A (photo)sensitive subject: Combined agarose gel electrophoresis and photochemical studies show that 5-methyl-2-pyrimidone (see picture), the main chromophore of (6-4) photoproducts, behaves as a DNA photosensitizer. These results raise the question of whether the (6-4) lesions can act as Trojan horses, enhancing cyclobutane pyrimidine dimer (CPD) formation and oxidative damage. es_ES
dc.description.sponsorship We gratefully acknowledge support from the Spanish Government (CTQ2009-13699, CTQ2012-32621, RiRAAF RETICS RD12/0013/0009, Ramon y Cajal contract RyC2007-00476 to V.L.-V. and JAE-Predoc 2011-00740 to V.V.-C.). en_EN
dc.language Inglés es_ES
dc.publisher Wiley-VCH Verlag es_ES
dc.relation.ispartof Angewandte Chemie International Edition es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Cyclobutane pyrimidine dimers es_ES
dc.subject DNA damage es_ES
dc.subject Photochemistry es_ES
dc.subject Pyrimidones es_ES
dc.subject Triplet excited states es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.title Photosensitization of DNA by 5-methyl-2pyrimidone deoxyribonucleoside: (6-4) photoproduct as a posible trojan horse es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1002/anie.201302176
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CTQ2012-32621/ES/FOTOQUIMICA DE LA FORMACION Y REPARACION DE LESIONES BIPIRIMIDINICAS DE TIPO (6-4), DEWAR Y ESPORA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//CTQ2009-13699/ES/CTQ2009-13699/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//RD12%2F0013%2F0009/ES/REACCIONES ADVERSAS A ALERGENOS Y FARMACOS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MEC//RYC-2007-00476/ES/RYC-2007-00476/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química es_ES
dc.description.bibliographicCitation Vendrell Criado, V.; Rodríguez Muñiz, GM.; Cuquerella Alabort, MC.; Lhiaubet, VL.; Miranda Alonso, MÁ. (2013). Photosensitization of DNA by 5-methyl-2pyrimidone deoxyribonucleoside: (6-4) photoproduct as a posible trojan horse. Angewandte Chemie International Edition. 52(25):6476-6479. doi:10.1002/anie.201302176 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1002/anie.201302176 es_ES
dc.description.upvformatpinicio 6476 es_ES
dc.description.upvformatpfin 6479 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 52 es_ES
dc.description.issue 25 es_ES
dc.relation.senia 256832
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