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Photosensitization of DNA by 5-methyl-2pyrimidone deoxyribonucleoside: (6-4) photoproduct as a posible trojan horse

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Photosensitization of DNA by 5-methyl-2pyrimidone deoxyribonucleoside: (6-4) photoproduct as a posible trojan horse

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Vendrell Criado, V.; Rodríguez Muñiz, GM.; Cuquerella Alabort, MC.; Lhiaubet, VL.; Miranda Alonso, MÁ. (2013). Photosensitization of DNA by 5-methyl-2pyrimidone deoxyribonucleoside: (6-4) photoproduct as a posible trojan horse. Angewandte Chemie International Edition. 52(25):6476-6479. doi:10.1002/anie.201302176

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Título: Photosensitization of DNA by 5-methyl-2pyrimidone deoxyribonucleoside: (6-4) photoproduct as a posible trojan horse
Autor: Vendrell Criado, Victoria Rodríguez Muñiz, Gemma María Cuquerella Alabort, Maria Consuelo Lhiaubet, Virginie Lyria Miranda Alonso, Miguel Ángel
Entidad UPV: Universitat Politècnica de València. Departamento de Química - Departament de Química
Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química
Fecha difusión:
Resumen:
A (photo)sensitive subject: Combined agarose gel electrophoresis and photochemical studies show that 5-methyl-2-pyrimidone (see picture), the main chromophore of (6-4) photoproducts, behaves as a DNA photosensitizer. These ...[+]
Palabras clave: Cyclobutane pyrimidine dimers , DNA damage , Photochemistry , Pyrimidones , Triplet excited states
Derechos de uso: Cerrado
Fuente:
Angewandte Chemie International Edition. (issn: 1433-7851 )
DOI: 10.1002/anie.201302176
Editorial:
Wiley-VCH Verlag
Versión del editor: http://dx.doi.org/10.1002/anie.201302176
Código del Proyecto:
info:eu-repo/grantAgreement/MINECO//CTQ2012-32621/ES/FOTOQUIMICA DE LA FORMACION Y REPARACION DE LESIONES BIPIRIMIDINICAS DE TIPO (6-4), DEWAR Y ESPORA/
info:eu-repo/grantAgreement/MICINN//CTQ2009-13699/ES/CTQ2009-13699/
info:eu-repo/grantAgreement/MINECO//RD12%2F0013%2F0009/ES/REACCIONES ADVERSAS A ALERGENOS Y FARMACOS/
info:eu-repo/grantAgreement/MEC//RYC-2007-00476/ES/RYC-2007-00476/
Agradecimientos:
We gratefully acknowledge support from the Spanish Government (CTQ2009-13699, CTQ2012-32621, RiRAAF RETICS RD12/0013/0009, Ramon y Cajal contract RyC2007-00476 to V.L.-V. and JAE-Predoc 2011-00740 to V.V.-C.).
Tipo: Artículo

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