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One-dimensional migration of olfactory ensheathing cells on synthetic materials: Experimental and numerical characterization

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One-dimensional migration of olfactory ensheathing cells on synthetic materials: Experimental and numerical characterization

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dc.contributor.author Perez Garnes, Manuel es_ES
dc.contributor.author Martínez Ramos, Cristina es_ES
dc.contributor.author Barcia, Juan A. es_ES
dc.contributor.author Escobar Ivirico, Jorge Luis es_ES
dc.contributor.author Gomez Pinedo, Ulises Alfonso es_ES
dc.contributor.author Vallés Lluch, Ana es_ES
dc.contributor.author Monleón Pradas, Manuel es_ES
dc.date.accessioned 2015-03-23T11:43:37Z
dc.date.available 2015-03-23T11:43:37Z
dc.date.issued 2013-07-24
dc.identifier.issn 1085-9195
dc.identifier.uri http://hdl.handle.net/10251/48191
dc.description.abstract Olfactory ensheathing cells (OECs) are of great interest for regenerative purposes since they are believed to aid axonal growth. With the view set on the strategies to achieve reconnection between neuronal structures, it is of great importance to characterize the behaviour of these cells on long thread-like structures that may efficiently guide cell spread in a targeted way. Here, rat OECs were studied on polycaprolactone (PCL) long monofilaments, on long bars and on discs. PCL turns out to be an excellent substrate for OECs. The cells cover long distances along the monofilaments and colonize completely these struc- tures. With the help of a one-dimensional (1D) analytical model, a migration coefficient, a net proliferation rate constant and the fraction of all cells which undergo migration were obtained. The separate effect of the three phenomena summarized by these parameters on the colo- nization patterns of the 1D path was qualitatively dis- cussed. Other features of interest were also determined, such as the speed of the advance front of colonization and the order of the kinetics of net cell proliferation. Charac- terizing migration by means of these quantities may be useful for comparing and predicting features of the colo- nization process (such as times, patterns, advance fronts and proportion of motile cells) of different cell substrate combinations. es_ES
dc.description.sponsorship Support of the Spanish Science & Innovation Ministery through project MAT2008-06434 is acknowledged. MMP and CMR acknowledge partial funding through the "Convenio de Colaboracion para la Investigacion Basica y Traslacional en Medicina Regenerativa" between the Instituto Nacional de Salud Carlos III, the Conselleria de Sanidad of the Generalitat Valenciana and the Foundation Centro de Investigacion Principe Felipe. en_EN
dc.language Inglés es_ES
dc.publisher Humana Press es_ES
dc.relation.ispartof Cell Biochemistry and Biophysics es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Olfactory ensheathing cells es_ES
dc.subject Polycaprolactone scaffolds es_ES
dc.subject Migration es_ES
dc.subject Diffusion es_ES
dc.subject Colonization es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title One-dimensional migration of olfactory ensheathing cells on synthetic materials: Experimental and numerical characterization es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s12013-012-9399-1
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//MAT2008-06434/ES/MATERIALES PARA REGENERACION NEURAL Y ANGIOGENESIS EN EL SISTEMA NERVIOSO CENTRAL/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular es_ES
dc.description.bibliographicCitation Perez Garnes, M.; Martínez Ramos, C.; Barcia, JA.; Escobar Ivirico, JL.; Gomez Pinedo, UA.; Vallés Lluch, A.; Monleón Pradas, M. (2013). One-dimensional migration of olfactory ensheathing cells on synthetic materials: Experimental and numerical characterization. Cell Biochemistry and Biophysics. 65:21-36. https://doi.org/10.1007/s12013-012-9399-1 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1007/s12013-012-9399-1 es_ES
dc.description.upvformatpinicio 21 es_ES
dc.description.upvformatpfin 36 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 65 es_ES
dc.relation.senia 235258
dc.identifier.eissn 1559-0283
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Centro de Investigación Príncipe Felipe es_ES
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