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Synthesis and properties of caprolactone and ethylene glycol copolymers for neural regeneration

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Synthesis and properties of caprolactone and ethylene glycol copolymers for neural regeneration

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Nombre: Escobar;García;Araque ...
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dc.contributor.author Escobar Ivirico, Jorge Luis es_ES
dc.contributor.author García Cruz, Dunia Mercedes es_ES
dc.contributor.author Araque Monrós, María Carmen es_ES
dc.contributor.author Martínez Ramos, Cristina es_ES
dc.contributor.author Monleón Pradas, Manuel es_ES
dc.date.accessioned 2015-11-24T08:29:42Z
dc.date.available 2015-11-24T08:29:42Z
dc.date.issued 2012-07
dc.identifier.issn 0957-4530
dc.identifier.uri http://hdl.handle.net/10251/57972
dc.description.abstract Copolymer networks from poly(ethylene glycol) methacrylate (PEGMA) and caprolactone 2-(methacryloyloxy) ethyl ester were synthesized and the resulting structure of the copolymer network was characterized by differential scanning calorimetry, thermogravimetry, Fourier transform infrared spectroscopy, equilibrium water gain and dynamic mechanical analysis, results which were employed to conclude about the network structure of the resulting copolymers. The new material is a random copolymer with a good miscibility and increasing hydrophilicity as the PEGMA content increases in the composition. Physical data suggest an excess free volume and synergistic interactions between the lateral chains of both comonomers. Olfactory ensheathing cells were cultured on the different networks, and cell viability and proliferation were assessed by MTS assay. The copolymers with a 30 wt% of PEGMA showed the best results compared with the other compositions in this respect, indicating the relevance for biological performance of a balance of hydrophilic and hydrophobic functionalities in the polymer chain. © Springer Science+Business Media, LLC 2012. es_ES
dc.description.sponsorship The authors acknowledge the support of the Spanish Science & Innovation Ministry through project MAT2008-06434 and the funding by the Centro de Investigacion Principe Felipe through the collaboration agreement from the Conselleria de Sanidad (Generalitat Valenciana) and the Instituto de Salud Carlos III (Ministry of Science and Innovation). JLEI acknowledges the support of Spanish Science & Innovation Ministry through the "Campus de Excelencia Internacional'' program consistent with Polytechnic University of Valencia. en_EN
dc.language Inglés es_ES
dc.publisher Springer Verlag (Germany) es_ES
dc.relation.ispartof Journal of Materials Science: Materials in Medicine es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Biological performance es_ES
dc.subject Caprolactone es_ES
dc.subject Cell viability es_ES
dc.subject Comonomers es_ES
dc.subject Copolymer networks es_ES
dc.subject Ethyl esters es_ES
dc.subject Hydrophilic and hydrophobic es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Synthesis and properties of caprolactone and ethylene glycol copolymers for neural regeneration es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s10856-012-4649-8
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//MAT2008-06434/ES/MATERIALES PARA REGENERACION NEURAL Y ANGIOGENESIS EN EL SISTEMA NERVIOSO CENTRAL/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Escobar Ivirico, JL.; García Cruz, DM.; Araque Monrós, MC.; Martínez Ramos, C.; Monleón Pradas, M. (2012). Synthesis and properties of caprolactone and ethylene glycol copolymers for neural regeneration. Journal of Materials Science: Materials in Medicine. 23(7):1605-1617. https://doi.org/10.1007/s10856-012-4649-8 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1007/s10856-012-4649-8 es_ES
dc.description.upvformatpinicio 1605 es_ES
dc.description.upvformatpfin 1617 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 23 es_ES
dc.description.issue 7 es_ES
dc.relation.senia 235619 es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Centro de Investigación Príncipe Felipe es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
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