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dc.contributor.author | Bauerl, Christine![]() |
es_ES |
dc.contributor.author | Collado Amores, María Carmen![]() |
es_ES |
dc.contributor.author | Zúñiga Cabrera, Manuel![]() |
es_ES |
dc.contributor.author | Blas Ferrer, Enrique![]() |
es_ES |
dc.contributor.author | Perez Martinez, Gaspar![]() |
es_ES |
dc.date.accessioned | 2016-01-13T11:26:26Z | |
dc.date.available | 2016-01-13T11:26:26Z | |
dc.date.issued | 2014-08 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/10251/59799 | |
dc.description.abstract | Epizootic Rabbit Enteropathy (ERE) is a severe disease of unknown aetiology that mainly affects post-weaning animals. Its incidence can be prevented by antibiotic treatment suggesting that bacterial elements are crucial for the development of the disease. Microbial dynamics and host responses during the disease were studied. Cecal microbiota was characterized in three rabbit groups (ERE-affected, healthy and healthy pretreated with antibiotics), followed by transcriptional analysis of cytokines and mucins in the cecal mucosa and vermix by q-rtPCR. In healthy animals, cecal microbiota with or without antibiotic pretreatment was very similar and dominated by Alistipes and Ruminococcus. Proportions of both genera decreased in ERE rabbits whereas Bacteroides, Akkermansia and Rikenella increased, as well as Clostridium, c-Proteobacteria and other opportunistic and pathogenic species. The ERE group displayed remarkable dysbiosis and reduced taxonomic diversity. Transcription rate of mucins and inflammatory cytokines was very high in ERE rabbits, except IL-2, and its analysis revealed the existence of two clearly different gene expression patterns corresponding to Inflammatory and (mucin) Secretory Profiles. Furthermore, these profiles were associated to different bacterial species, suggesting that they may correspond to different stages of the disease. Other data obtained in this work reinforced the notion that ERE morbidity and mortality is possibly caused by an overgrowth of different pathogens in the gut of animals whose immune defence mechanisms seem not to be adequately responding. | es_ES |
dc.description.sponsorship | This work was supported by the grants AGL2010-22211, AGL2006-07596 and by the Fun-C-Food CSD2007-00063 project from the Consolider-Ingenio programme, both from the Spanish Ministry of Science and Innovation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | Public Library of Science | es_ES |
dc.relation.ispartof | PLoS ONE | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.subject | Epizootic Rabbit Enteropathy (ERE) | es_ES |
dc.subject | Cecal microbiota | es_ES |
dc.subject.classification | PRODUCCION ANIMAL | es_ES |
dc.subject.classification | NUTRICION Y BROMATOLOGIA | es_ES |
dc.title | Changes in caecal microbiota and mucosal gene expression revealed new aspects of Epizootic rabbit Enteropathy | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0105707 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//AGL2010-22211/ES/MECANISMO DE ACCION PROBIOTICA EN CEPAS DEL GRUPO LACTOBACILLUS CASEI-PARACASEI%2FRHAMNOSUS: IDENTIFICACION DE MOLECULAS CLAVE MEDIANTE MODELOS IN VITRO./ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MEC//AGL2006-07596/ES/DESARROLLO DE ESTRATEGIAS GLOBALES DE ALIMENTACION Y MANEJO PARA MEJORAR LA SALUD Y EL BIENESTAR EN LAS GRANJAS CUNICOLAS/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MEC//CSD2007-00063/ES/Nuevos Ingredientes de Alimentos Funcionales para Mejorar la Salud/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto de Ciencia y Tecnología Animal - Institut de Ciència i Tecnologia Animal | es_ES |
dc.description.bibliographicCitation | Bauerl, C.; Collado Amores, MC.; Zúñiga Cabrera, M.; Blas Ferrer, E.; Perez Martinez, G. (2014). Changes in caecal microbiota and mucosal gene expression revealed new aspects of Epizootic rabbit Enteropathy. PLoS ONE. 9(8):1-12. https://doi.org/10.1371/journal.pone.0105707 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi.org/105707. doi:10.1371/journal.pone.0105707 | es_ES |
dc.description.upvformatpinicio | 1 | es_ES |
dc.description.upvformatpfin | 12 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 9 | es_ES |
dc.description.issue | 8 | es_ES |
dc.relation.senia | 287925 | es_ES |
dc.identifier.pmid | 25147938 | en_EN |
dc.identifier.pmcid | PMC4141808 | en_EN |
dc.contributor.funder | Ministerio de Educación y Ciencia | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es_ES |
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