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Multisite organic-inorganic hybrid catalysts for the direct sustainable synthesis of GABAergic drugs

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Multisite organic-inorganic hybrid catalysts for the direct sustainable synthesis of GABAergic drugs

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dc.contributor.author Leyva Perez, Antonio es_ES
dc.contributor.author García García, Pilar es_ES
dc.contributor.author Corma Canós, Avelino es_ES
dc.date.accessioned 2016-01-18T09:31:45Z
dc.date.issued 2014-08-11
dc.identifier.issn 1433-7851
dc.identifier.uri http://hdl.handle.net/10251/59969
dc.description.abstract Multisite organic inorganic hybrid catalysts have been prepared and applied in a new general, practical, and sustainable synthetic procedure toward industrially relevant GABA derivatives. The domino sequence is composed of seven chemical transformations which are performed in two one-pot reactions. The method produces both enantiomeric forms of the product in high enantiopurity as well as the racemate in good yields after a single column purification step. This protocol highlights major process intensification, catalyst recyclability, and low waste generation. es_ES
dc.description.sponsorship This work was supported by the Spanish Government (Consolider Ingenio 2010-MULTICAT (CSD2009-00050) and MAT2011-29020-C02-01). P.G.-G. is grateful for a JAE-DOC contract from CSIC cofunded by the ESF. A.L.P. thanks ITQ for a contract. The Severo Ochoa program is thankfully acknowledged. en_EN
dc.language Inglés es_ES
dc.publisher Wiley-VCH Verlag es_ES
dc.relation Spanish Government CSD2009-00050 MAT2011-29020-C02-01 es_ES
dc.relation.ispartof Angewandte Chemie International Edition es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject gamma-aminobutyric acid es_ES
dc.subject domino reactions es_ES
dc.subject GABAergic drug synthesis es_ES
dc.subject heterogeneous catalysis es_ES
dc.subject organic-inorganic hybrid catalysts es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Multisite organic-inorganic hybrid catalysts for the direct sustainable synthesis of GABAergic drugs es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1002/anie.201403049
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Leyva Perez, A.; García García, P.; Corma Canós, A. (2014). Multisite organic-inorganic hybrid catalysts for the direct sustainable synthesis of GABAergic drugs. Angewandte Chemie International Edition. 53(33):8687-8690. doi:10.1002/anie.201403049 es_ES
dc.description.accrualMethod Senia es_ES
dc.relation.publisherversion http://dx.doi.org/10.1002/anie.201403049 es_ES
dc.description.upvformatpinicio 8687 es_ES
dc.description.upvformatpfin 8690 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 53 es_ES
dc.description.issue 33 es_ES
dc.relation.senia 282347 es_ES
dc.identifier.eissn 1521-3773


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