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dc.contributor.author | Leyva Perez, Antonio | es_ES |
dc.contributor.author | García García, Pilar | es_ES |
dc.contributor.author | Corma Canós, Avelino | es_ES |
dc.date.accessioned | 2016-01-18T09:31:45Z | |
dc.date.issued | 2014-08-11 | |
dc.identifier.issn | 1433-7851 | |
dc.identifier.uri | http://hdl.handle.net/10251/59969 | |
dc.description.abstract | Multisite organic inorganic hybrid catalysts have been prepared and applied in a new general, practical, and sustainable synthetic procedure toward industrially relevant GABA derivatives. The domino sequence is composed of seven chemical transformations which are performed in two one-pot reactions. The method produces both enantiomeric forms of the product in high enantiopurity as well as the racemate in good yields after a single column purification step. This protocol highlights major process intensification, catalyst recyclability, and low waste generation. | es_ES |
dc.description.sponsorship | This work was supported by the Spanish Government (Consolider Ingenio 2010-MULTICAT (CSD2009-00050) and MAT2011-29020-C02-01). P.G.-G. is grateful for a JAE-DOC contract from CSIC cofunded by the ESF. A.L.P. thanks ITQ for a contract. The Severo Ochoa program is thankfully acknowledged. | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | Wiley-VCH Verlag | es_ES |
dc.relation.ispartof | Angewandte Chemie International Edition | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | gamma-aminobutyric acid | es_ES |
dc.subject | domino reactions | es_ES |
dc.subject | GABAergic drug synthesis | es_ES |
dc.subject | heterogeneous catalysis | es_ES |
dc.subject | organic-inorganic hybrid catalysts | es_ES |
dc.subject.classification | QUIMICA ORGANICA | es_ES |
dc.title | Multisite organic-inorganic hybrid catalysts for the direct sustainable synthesis of GABAergic drugs | es_ES |
dc.type | Artículo | es_ES |
dc.embargo.lift | 10000-01-01 | |
dc.embargo.terms | forever | es_ES |
dc.identifier.doi | 10.1002/anie.201403049 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//CSD2009-00050/ES/Desarrollo de catalizadores más eficientes para el diseño de procesos químicos sostenibles y produccion limpia de energia/ | es_ES |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Química - Departament de Química | es_ES |
dc.description.bibliographicCitation | Leyva Perez, A.; García García, P.; Corma Canós, A. (2014). Multisite organic-inorganic hybrid catalysts for the direct sustainable synthesis of GABAergic drugs. Angewandte Chemie International Edition. 53(33):8687-8690. https://doi.org/10.1002/anie.201403049 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1002/anie.201403049 | es_ES |
dc.description.upvformatpinicio | 8687 | es_ES |
dc.description.upvformatpfin | 8690 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 53 | es_ES |
dc.description.issue | 33 | es_ES |
dc.relation.senia | 282347 | es_ES |
dc.identifier.eissn | 1521-3773 | |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es_ES |
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