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Cathepsin-B Induced Controlled Release from Peptide-Capped Mesoporous Silica Nanoparticles

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Cathepsin-B Induced Controlled Release from Peptide-Capped Mesoporous Silica Nanoparticles

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dc.contributor.author de la torre, Cristina es_ES
dc.contributor.author Mondragón Martínez, Laura es_ES
dc.contributor.author Coll Merino, Mª Carmen es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.contributor.author Marcos Martínez, María Dolores es_ES
dc.contributor.author Martínez Mañez, Ramón es_ES
dc.contributor.author Amoros del Toro, Pedro Jose es_ES
dc.contributor.author Pérez Payá, Enrique es_ES
dc.contributor.author Orzáez Calatayud, Mar es_ES
dc.date.accessioned 2016-01-21T09:48:30Z
dc.date.issued 2014-11-17
dc.identifier.issn 0947-6539
dc.identifier.uri http://hdl.handle.net/10251/60098
dc.description.abstract New capped silica mesoporous nanoparticles for intracellular controlled cargo release within cathepsin B expressing cells are described. Nanometric mesoporous MCM-41 supports loaded with safranin O (S1-P) or doxorubicin (S2-P) containing a molecular gate based on a cathepsin B target peptidic sequence were synthesized. Solids were designed to show "zero delivery" and to display cargo release in the presence of cathepsin B enzyme, which selectively hydrolyzed in vitro the capping peptide sequence. Controlled delivery in HeLa, MEFs WT, and MEFs lacking cathepsin B cell lines were also tested. Release of safranin O and doxorubicin in these cells took place when cathepsin B was active or present. Cells treated with S2-P showed a fall in cell viability due to nanoparticles internalization, cathepsin B hydrolysis of the capping peptide, and cytotoxic agent delivery, proving the possible use of these nanodevices as new therapeutic tools for cancer treatment. es_ES
dc.description.sponsorship We thank the Spanish Government (Project MAT2012-38429-C04 and SAF2010-15512) and the Generalitat Valenciana (Project PROMETEO/2009/016 and PROMETEOII/2014/061) for support. C. T. is grateful to the Spanish Ministry of Science and Innovation for her PhD fellowship. L. M. thanks the Generalitat Valenciana and Nice city council for their postdoctoral contracts VALI+D and "Aides Individuelles aux Jeunes Chercheurs 2011". C. C. thanks the Generalitat Valenciana for their postdoctoral contract VALI+D. M.O. thanks the CIPF for her postdoctoral fellowship. We thank the confocal microscopy service, Alberto Hernndez and Eva Mara La Fuente from CIPF for their technical support. en_EN
dc.language Inglés es_ES
dc.publisher Wiley-VCH Verlag es_ES
dc.relation.ispartof Chemistry - A European Journal es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Cathepsin B es_ES
dc.subject controlled release es_ES
dc.subject gated mesoporous materials es_ES
dc.subject nanoparticles es_ES
dc.subject peptides es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.subject.classification INGENIERIA DE LA CONSTRUCCION es_ES
dc.title Cathepsin-B Induced Controlled Release from Peptide-Capped Mesoporous Silica Nanoparticles es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1002/chem.201404382
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//SAF2010-15512/ES/MECANISMOS MOLECULARES DE MODULADORES DE APOPTOSIS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Generalitat Valenciana//PROMETEO09%2F2009%2F016/ES/Ayuda prometeo 2009 para el grupo de diseño y desarrollo de sensores/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation De La Torre, C.; Mondragón Martínez, L.; Coll Merino, MC.; Sancenón Galarza, F.; Marcos Martínez, MD.; Martínez Mañez, R.; Amoros Del Toro, PJ.... (2014). Cathepsin-B Induced Controlled Release from Peptide-Capped Mesoporous Silica Nanoparticles. Chemistry - A European Journal. 20(47):15309-15314. https://doi.org/10.1002/chem.201404382 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1002/chem.201404382 es_ES
dc.description.upvformatpinicio 15309 es_ES
dc.description.upvformatpfin 15314 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 20 es_ES
dc.description.issue 47 es_ES
dc.relation.senia 276590 es_ES
dc.identifier.eissn 1521-3765
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Centro de Investigación Príncipe Felipe es_ES
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