Ferrian, S.; Blas Ferrer, E.; Larsen, T.; Sánchez Serrano, JP.; Friggens, NC.; Corpa, JM.; Baselga Izquierdo, M.... (2013). Comparison of immune response to lipopolysaccharide of rabbit does selected for litter size at weaning or founded for reproductive longevity. Research in Veterinary Science. 94(3):518-525. doi:10.1016/j.rvsc.2013.01.008
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/61549
Title:
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Comparison of immune response to lipopolysaccharide of rabbit does selected for litter size at weaning or founded for reproductive longevity
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Author:
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Ferrian, Selena
Blas Ferrer, Enrique
Larsen, T.
Sánchez Serrano, Juan Pablo
Friggens, Nicholas Charles
Corpa, J. M.
Baselga Izquierdo, Manuel
Pascual Amorós, Juan José
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UPV Unit:
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Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal
Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Agrónomos - Escola Tècnica Superior d'Enginyers Agrònoms
Universitat Politècnica de València. Instituto de Ciencia y Tecnología Animal - Institut de Ciència i Tecnologia Animal
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Issued date:
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Abstract:
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To evaluate differences in maternal lines to the immune response of reproductive rabbit does, a total of 64 animals of two different lines: (1) founded for hyper-longevity and litter size criteria (LP) and (2) selected for ...[+]
To evaluate differences in maternal lines to the immune response of reproductive rabbit does, a total of 64 animals of two different lines: (1) founded for hyper-longevity and litter size criteria (LP) and (2) selected for litter size at weaning (V) were used. Females were subjected to three different reproductive efforts: post-partum (PP) mating at first lactation and 9 kits during the second; post-weaning (PW) mating at first lactation and 9 kits during the second; and PW mating at first lactation and 5 kits during the second. At second weaning (30 days PP), an acute response was induced by intravenous infusion of lipopolysaccharide (LPS). LP females seemed to be lower affected during the hyper-acute phase than V females, showing lower plasma glucose content at 1.5 h post infusion (pi) and rectal temperature at 6 h pi; and showed higher ulterior immune response, with higher levels of C-reactive protein at 48 h pi and haptoglobin in plasma from 24 h pi. Survival test conferred a higher risk of culling for V than for LP females during the first hours after challenge. These results may suggest that, regarding immune response to LPS challenge, foundation by hyper-longevity productive criteria lead to obtain a more robust population of rabbit does, characterized by improved response ability. (C) 2013 Elsevier Ltd. All rights reserved.
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Subjects:
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Rabbit doe
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Immunological challenge
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Genetic selection
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Litter size
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Longevity
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Copyrigths:
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Reserva de todos los derechos
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Source:
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Research in Veterinary Science. (issn:
0034-5288
)
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DOI:
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10.1016/j.rvsc.2013.01.008
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Publisher:
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Elsevier
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Publisher version:
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http://dx.doi.org/10.1016/j.rvsc.2013.01.008
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Project ID:
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info:eu-repo/grantAgreement/MICINN//AGL2011-30170-C02-02/ES/ESTUDIO DEL SISTEMA INMUNE DE DIFERENTES LINEAS GENETICAS CUNICOLAS Y SU RESPUESTA FRENTE A DESAFIOS PRODUCTIVOS E INFECCIOSOS/
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Thanks:
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This study has been supported by the Interministerial Commission for Science and Technology (CICYT) from the Spanish Government. Grants Number: AGL2011-30170-C02-01; AGL2011-30170-C02-02), is gratefully acknowledged.
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Type:
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Artículo
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