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Solid Catalysts for Multistep Reactions: One- Pot Synthesis of 2,3-Dihydro-1,5-benzothiazepines with Solid Acid and Base Catalysts

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Solid Catalysts for Multistep Reactions: One- Pot Synthesis of 2,3-Dihydro-1,5-benzothiazepines with Solid Acid and Base Catalysts

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dc.contributor.author Climent Olmedo, María José es_ES
dc.contributor.author Corma Canós, Avelino es_ES
dc.contributor.author Iborra Chornet, Sara es_ES
dc.contributor.author Martí Montaner, Laura es_ES
dc.date.accessioned 2016-03-30T09:12:55Z
dc.date.issued 2014-04
dc.identifier.issn 1864-5631
dc.identifier.uri http://hdl.handle.net/10251/62078
dc.description.abstract 1,5-Benzothiazepines derivatives were obtained first by starting from 1,3-diphenylpropenone derivatives (chalcones) and 2-aminothiophenol by using aluminosilicate solid catalysts. However, diffusional limitations and the strong adsorption of products on the catalyst are deleterious for catalyst activity and life. Then a structured amorphous mesoporous catalyst with large pores and mild acidity that works at higher temperatures allowed us to obtain high conversions (99%) and selectivities (98%) of the desired product. A one-pot synthesis of 1,5-benzothiazepines that starts from benzaldehyde, acetophenone, and 2-aminothiophenol with 95% yield was performed by combining optimized solid base and acid catalysts in batch mode as well as in a continuous-flow reactor system. Much better conversion and selectivity as well as process intensification has been achieved with the structured mesoporous materials by avoiding intermediate and final neutralization and purification steps required in the synthesis reported previously that uses homogeneous catalysts. es_ES
dc.description.sponsorship The authors acknowledge the Spanish Ministry of Education and Science for financial support in the project Consolider-Ingenio 2010 and CTQ-2011-27550. L. M. thanks the Spanish Ministry of Education and Science for a Jae-Predoc grant, co-financed by the European Social Fund Plan 2007-2013. en_EN
dc.language Inglés es_ES
dc.publisher Wiley-VCH Verlag es_ES
dc.relation.ispartof ChemSusChem es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject cyclization es_ES
dc.subject heterocycles es_ES
dc.subject heterogeneous catalysis es_ES
dc.subject mesoporous materials es_ES
dc.subject multicomponent reactions es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Solid Catalysts for Multistep Reactions: One- Pot Synthesis of 2,3-Dihydro-1,5-benzothiazepines with Solid Acid and Base Catalysts es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1002/cssc.201301064
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//CTQ2011-27550/ES/TRANSFORMACION CATALITICA DE BIOMASA EN DIESEL Y EN PRODUCTOS QUIMICOS/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química es_ES
dc.description.bibliographicCitation Climent Olmedo, MJ.; Corma Canós, A.; Iborra Chornet, S.; Martí Montaner, L. (2014). Solid Catalysts for Multistep Reactions: One- Pot Synthesis of 2,3-Dihydro-1,5-benzothiazepines with Solid Acid and Base Catalysts. ChemSusChem. 7(4):1177-1185. https://doi.org/10.1002/cssc.201301064 es_ES
dc.description.accrualMethod S es_ES
dc.description.upvformatpinicio 1177 es_ES
dc.description.upvformatpfin 1185 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 7 es_ES
dc.description.issue 4 es_ES
dc.relation.senia 281669 es_ES
dc.identifier.eissn 1864-564X
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder European Social Fund es_ES
dc.contributor.funder Ministerio de Educación y Ciencia es_ES
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