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Location of chlorogenic acid biosynthesis pathway and poliphenol oxidase genes in a new interspecific anchored linkage map of eggplant

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Location of chlorogenic acid biosynthesis pathway and poliphenol oxidase genes in a new interspecific anchored linkage map of eggplant

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Gramazio, P.; Prohens Tomás, J.; Plazas Ávila, MDLO.; Andújar Pérez, I.; Herraiz García, FJ.; Castillo Lorenzo, E.; Knapp, S.... (2014). Location of chlorogenic acid biosynthesis pathway and poliphenol oxidase genes in a new interspecific anchored linkage map of eggplant. BMC Plant Biology. 14(350):1-15. doi:10.1186/s12870-014-0350-z

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Title: Location of chlorogenic acid biosynthesis pathway and poliphenol oxidase genes in a new interspecific anchored linkage map of eggplant
UPV Unit: Universitat Politècnica de València. Instituto Universitario de Conservación y Mejora de la Agrodiversidad Valenciana - Institut Universitari de Conservació i Millora de l'Agrodiversitat Valenciana
Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia
Issued date:
Background Eggplant is a powerful source of polyphenols which seems to play a key role in the prevention of several human diseases, such as cancer and diabetes. Chlorogenic acid is the polyphenol most present in eggplant, ...[+]
Subjects: Chlorogenic acid , Genetic map , Polyphenol oxidases , Solanum incanum , Solanum melongena , Synteny
Copyrigths: Reconocimiento (by)
BMC Plant Biology. (issn: 1471-2229 )
DOI: 10.1186/s12870-014-0350-z
BioMed Central
Publisher version: http://dx.doi.org/10.1186/s12870-014-0350-z
This research has been partially funded by Ministerio de Economa y Competitividad and FEDER (grant AGL2012-34213). Pietro Gramazio is grateful to Universitat Politcnica de Valncia for a pre-doctoral grant.
Type: Artículo


Daunay MC, Lester RN: Eggplant. Tropical Plant Breeding. Edited by: Charrier A, Jacquot M, Hamon S, Nicolas D. 2001, CIRAD, SciencePublishers Inc, Plymouth, UK, 199-221.

Hanson PM, Yang R, Tsou S, Ledesma D, Engle L, Lee T: Diversity in eggplant (Solanum melongena) for superoxide scavenging activity, total phenolics, and ascorbic acid. J Food Compos Anal. 2006, 19: 594-600. 10.1016/j.jfca.2006.03.001.

Lo Scalzo R, Fibiani M, Mennella G, Rotino GL, Dal Sasso M, Culici M, Spallino A, Braga PC: Thermal treatment of eggplant (Solanum melongena L.) increases the antioxidant content and the inhibitory effect on human neutrophil burst. J Agric Food Chem. 2010, 58: 3371-3379. 10.1021/jf903881s. [+]
Daunay MC, Lester RN: Eggplant. Tropical Plant Breeding. Edited by: Charrier A, Jacquot M, Hamon S, Nicolas D. 2001, CIRAD, SciencePublishers Inc, Plymouth, UK, 199-221.

Hanson PM, Yang R, Tsou S, Ledesma D, Engle L, Lee T: Diversity in eggplant (Solanum melongena) for superoxide scavenging activity, total phenolics, and ascorbic acid. J Food Compos Anal. 2006, 19: 594-600. 10.1016/j.jfca.2006.03.001.

Lo Scalzo R, Fibiani M, Mennella G, Rotino GL, Dal Sasso M, Culici M, Spallino A, Braga PC: Thermal treatment of eggplant (Solanum melongena L.) increases the antioxidant content and the inhibitory effect on human neutrophil burst. J Agric Food Chem. 2010, 58: 3371-3379. 10.1021/jf903881s.

Plazas M, López-Gresa MP, Vilanova S, Torres C, Hurtado M, Gramazio P, Andújar I, Herráiz FJ, Bellés JM, Prohens J: Diversity and relationships in key traits for functional and apparent quality in a collection of eggplant: fruit phenolics content, antioxidant activity, polyphenol oxidase activity, and browning. J Agric Food Chem. 2013, 61: 8871-8879. 10.1021/jf402429k.

Plazas M, Andújar I, Vilanova S, Hurtado M, Gramazio P, Herraiz FJ, Prohens J: Breeding for chlorogenic acid content in eggplant: interest and prospects. Not Bot Horti Agrobot Cluj-Napoca. 2013, 41 (1): 26-35.

Mennella G, Lo Scalzo R, Fibiani M, D’Alessandro A, Francese G, Toppino L, Acciarri N, de Almeida AE, Rotino GL: Chemical and bioactive quality traits during fruit ripening in eggplant (S. melongena L.) and allied species. J Agric Food Chem. 2012, 60: 11821-11831. 10.1021/jf3037424.

Prohens J, Whitaker BD, Plazas M, Vilanova S, Hurtado M, Blasco M, Gramazio P, Stommel JR: Genetic diversity in morphological characters and phenolic acids content resulting from an interspecific cross between eggplant, Solanum melongena, and its wild ancestor (S. incanum). Ann Appl Biol. 2013, 162: 242-257. 10.1111/aab.12017.

Singh AP, Luthria D, Wilson T, Vorsa N, Singh V, Banuelos GS, Pasakdee S: Polyphenols content and antioxidant capacity of eggplant pulp. Food Chem. 2009, 114: 955-961. 10.1016/j.foodchem.2008.10.048.

Stommel JR, Whitaker BD: Phenolic acid content and composition of eggplant fruit in a germplasm core subset. J Am Soc Hort Sci. 2003, 128: 704-710.

Whitaker BD, Stommel JR: Distribution of hydroxycinnamic acid conjugates in fruit of commercial eggplant (Solanum melongena L.) cultivars. J Agric Food Chem. 2003, 51: 3448-3454. 10.1021/jf026250b.

Cho A, Jeon S, Kim M, Yeo J, Seo K, Choi M, Lee M: Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice. Food Chem Toxicol. 2010, 48: 937-943. 10.1016/j.fct.2010.01.003.

Dos Santos MD, Almeida MC, Lopes NP, De Souza GEP: Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid. Biol Pharm Bull. 2006, 29: 2236-2240. 10.1248/bpb.29.2236.

Luthria D, Singh AP, Wilson T, Vorsa N, Banuelos GS, Vinyard BT: Influence of conventional and organic agricultural practices on the phenolic content in eggplant pulp: plant-to-plant variation. Food Chem. 2010, 121: 406-411. 10.1016/j.foodchem.2009.12.055.

Lester RN, Hasan SMZ: Origin and domestication of the brinjal eggplant, Solanum melongena, from S. incanum, in Africa and Asia. Solanaceae III: Taxonomy, Chemistry, Evolution. Edited by: Hawkes JG, Lester RN, Nee MH, Estrada N. 1991, Royal Botanic Gardens, Kew, London, UK, 369-388.

Knapp S, Vorontsova MS, Prohens J: Wild relatives of the eggplant (Solanum melongena L.: Solanaceae): new understanding of species names in a complex group. PLoS One 2013, 8:e57039.,

Ma C, Dastmalchi K, Whitaker BD, Kennelly EJ: Two new antioxidant malonated caffeoylquinic acid isomers in fruits of wild eggplant relatives. J Agric Food Chem. 2011, 59: 9645-9651. 10.1021/jf202028y.

Ramirez EC, Whitaker JR, Virador VM: Polyphenol Oxidase. Handbook of Food Enzymology. Edited by: Whitaker JR, Voragen AGJ, Wong DWS. 2003, Marcel Dekker, Inc, New York, 509-524.

Concellón A, Zaro MJ, Chaves AR, Vicente AR: Changes in quality and phenolic antioxidants in dark purple American eggplant (Solanum melongena L. cv. Lucía) as affected by storage at 0°C and 10°C. Postharvest Biol Technol. 2012, 66: 35-41. 10.1016/j.postharvbio.2011.12.003.

Doğan M, Arslan O, Doğan S: Substrate specificity, heat inactivation and inhibition of polyphenol oxidase from different aubergine cultivars. Int J Food Sci Tech. 2002, 37: 415-423. 10.1046/j.1365-2621.2002.00580.x.

Shetty SM, Chandrashekar A, Venkatesh YP: Eggplant polyphenol oxidase multigene family: cloning, phylogeny, expression analyses and immunolocalization in response to wounding. Phytochemistry. 2011, 72: 2275-2287. 10.1016/j.phytochem.2011.08.028.

Comino C, Lanteri S, Portis E, Acquadro A, Romani A, Hehn A, Larbat R, Bourgaud F: Isolation and functional characterization of a cDNA coding a hydroxycinnamoyltransferase involved in phenylpropanoid biosynthesis in Cynara cardunculus L. BMC Plant Biol 2007, 7:14.,

Comino C, Hehn A, Moglia A, Menin B, Bourgaud F, Lanteri S, Portis E: The isolation and mapping of a novel hydroxycinnamoyltransferase in the globe artichoke chlorogenic acid pathway. BMC Plant Biol 2009, 9:30.,

Menin B, Comino C, Moglia A, Dolzhenko Y, Portis E, Lanteri S: Identification and mapping of genes related to caffeoylquinic acid synthesis in Cynara cardunculus L. Plant Sci. 2010, 179: 338-347. 10.1016/j.plantsci.2010.06.010.

Niggeweg R, Michael A, Martin C: Engineering plants with increased levels of the antioxidant chlorogenic acid. Nat Biotechnol. 2004, 22: 746-754. 10.1038/nbt966.

Nunome T, Ishiguro K, Yoshida T, Hirai M: Mapping of fruit shape and color development traits in eggplant (Solanum melongena L.) based on RAPD and AFLP markers. Breed Sci. 2001, 51: 19-26. 10.1270/jsbbs.51.19.

Nunome T, Suwabe K, Ohyama A, Fukuoka H: Characterization of trinucleotide microsatellites in eggplant. Breed Sci. 2003, 53: 77-83. 10.1270/jsbbs.53.77.

Nunome T, Negoro S, Kono I, Kanamori H, Miyatake K, Yamaguchi H, Ohyama A, Fukuoka H: Development of SSR markers derived from SSR-enriched genomic library of eggplant (Solanum melongena L.). Theor Appl Genet. 2009, 119: 1143-1153. 10.1007/s00122-009-1116-0.

Doganlar S, Frary A, Daunay M, Lester RN, Tanksley SD: A comparative genetic linkage map of eggplant (Solanum melongena) and its implications for genome evolution in the Solanaceae. Genetics. 2002, 161: 1697-1711.

Wu F, Eannetta NT, Xu Y, Tanksley SD: A detailed synteny map of the eggplant genome based on conserved ortholog set II (COSII) markers. Theor Appl Genet. 2009, 118: 927-935. 10.1007/s00122-008-0950-9.

Doganlar S, Frary A, Daunay M, Huvenaars K, Mank R, Frary A: High resolution map of eggplant (Solanum melongena) reveals extensive chromosome rearrangement in domesticated members of the Solanaceae. Euphytica. 2014, 197: 211-228. 10.1007/s10681-013-1060-6.

Barchi L, Lanteri S, Portis E, Stàgel A, Valè G, Toppino L, Rotino GL: Segregation distortion and linkage analysis in eggplant (Solanum melongena L.). Genome. 2010, 53: 805-815. 10.1139/G10-073.

Fukuoka H, Miyatake K, Nunome T, Negoro S, Shirasawa K, Isobe S, Asamizu E, Yamaguchi H, Ohyama A: Development of gene-based markers and construction of an integrated linkage map in eggplant by using Solanum orthologous (SOL) gene sets. Theor Appl Genet. 2012, 125: 47-56. 10.1007/s00122-012-1815-9.

Barchi L, Lanteri S, Portis E, Valè G, Volante A, Pulcini L, Ciriaci T, Acciarri N, Barbierato V, Toppino L: A RAD Tag derived marker based eggplant linkage map and the location of QTLs determining anthocyanin pigmentation. PLoS One 2012, 7:e43740.,

Fulton TM, Van der Hoeven R, Eannetta NT, Tanksley SD: Identification, analysis, and utilization of conserved ortholog set markers for comparative genomics in higher plants. Plant Cell. 2002, 14: 1457-1467. 10.1105/tpc.010479.

The Angiosperm Phylogeny Group: An update of the Angiosperm Phylogeny Group classification for the orders and families of flowering plants: APG II. Bot J Linn Soc. 2003, 141: 399-436. 10.1046/j.1095-8339.2003.t01-1-00158.x.

Vilanova S, Manzur JP, Prohens J: Development and characterization of genomic simple sequence repeat markers in eggplant and their application to the study of diversity and relationships in a collection of different cultivar types and origins. Mol Breed. 2012, 30: 647-660. 10.1007/s11032-011-9650-2.

Fukuoka H, Yamaguchi H, Nunome T, Negoro S, Miyatake K, Ohyama A: Accumulation, functional annotation, and comparative analysis of expressed sequence tags in eggplant (Solanum melongena L.), the third pole of the genus Solanum species after tomato and potato. Gene. 2010, 450: 76-84. 10.1016/j.gene.2009.10.006.

Barchi L, Lanteri S, Portis E, Acquadro A, Valè G, Toppino L, Rotino GL: Identification of SNP and SSR markers in eggplant using RAD tag sequencing. BMC Genomics 2011, 12:304.,

Jeuken M, Van Wijk R, Peleman J, Lindhout P: An integrated interspecific AFLP map of lettuce (Lactuca) based on two L. sativa × L. saligna F2 populations. Theor Appl Genet. 2001, 103: 638-647. 10.1007/s001220100657.

Shirasawa K, Ishii K, Kim C, Ban T, Suzuki M, Ito T, Muranaka T, Kobayashi M, Nagata N, Isobe S: Development of Capsicum EST–SSR markers for species identification and in silico mapping onto the tomato genome sequence. Mol Breed. 2013, 31: 101-110. 10.1007/s11032-012-9774-z.

Alheit KV, Reif JC, Maurer HP, Hahn V, Weissmann EA, Miedaner T, Würschum T: Detection of segregation distortion loci in triticale (x Triticosecale Wittmack) based on a high-density DArT marker consensus genetic linkage map. BMC Genomics 2011, 12:380.,

Ren Y, McGregor C, Zhang Y, Gong G, Zhang H, Guo S, Sun H, Cai W, Zhang J, Xu Y: An integrated genetic map based on four mapping populations and quantitative trait loci associated with economically important traits in watermelon (Citrullus lanatus). BMC Plant Biol 2014, 14:33.,

Prohens J, Rodríguez-Burruezo A, Raigón MD, Nuez F: Total phenolic concentration and browning susceptibility in a collection of different varietal types and hybrids of eggplant: implications for breeding for higher nutritional quality and reduced browning. J Am Soc Hort Sci. 2007, 132: 638-646.

Raigón MD, Prohens J, Muñoz-Falcón JE, Nuez F: Comparison of eggplant landraces and commercial varieties for fruit content of phenolics, minerals, dry matter and protein. J Food Compos Anal. 2008, 21: 370-376. 10.1016/j.jfca.2008.03.006.

Byrne P, McMullen M: Defining genes for agricultural traits: QTL analysis and the candidate gene approach. Proc Natl Acad Sci U S A. 1996, 7: 24-27.

Vogt T: Phenylpropanoid biosynthesis. Mol Plant. 2010, 3: 2-20. 10.1093/mp/ssp106.

Shi R, Shuford CM, Wang JP, Sun Y, Yang Z, Chen H, Tunlaya-Anukit S, Li Q, Liu J, Muddiman DC: Regulation of phenylalanine ammonia-lyase (PAL) gene family in wood forming tissue of Populus trichocarpa . Planta. 2013, 238: 487-497. 10.1007/s00425-013-1905-1.

Kumar A, Ellis BE: The phenylalanine ammonia-lyase gene family in raspberry. structure, expression, and evolution. Plant Physiol. 2001, 127: 230-239. 10.1104/pp.127.1.230.

Chagné D, Krieger C, Rassam M, Sullivan M, Fraser J, André C, Pindo M, Troggio M, Gardiner SE, Henry RA: QTL and candidate gene mapping for polyphenolic composition in apple fruit. BMC Plant Biol 2012, 12:12.,

Moglia A, Comino C, Menin B, Portis E, Aquadro A, Beekwilder MJ, Hehn A, Bourgaud F, Lanteri S: Caffeoylquinic acids biosynthesis and accumulation in Cynara cardunculus: state of the art. Acta Hort. 2013, 983: 401-405.

Portis E, Mauromicale G, Mauro R, Acquadro A, Scaglione D, Lanteri S: Construction of a reference molecular linkage map of globe artichoke (Cynara cardunculus var. scolymus). Theor Appl Genet. 2009, 120: 59-70. 10.1007/s00122-009-1159-2.

Portis E, Scaglione D, Acquadro A, Mauromicale G, Mauro R, Knapp SJ, Lanteri S: Genetic mapping and identification of QTL for earliness in the globe artichoke/cultivated cardoon complex. BMC Res Notes 2012, 5:252.,

Rommens CM, Richael CM, Yan H, Navarre DA, Ye J, Krucker M, Swords K: Engineered native pathways for high kaempferol and caffeoylquinate production in potato. Plant Biotechnol J. 2008, 6: 870-886. 10.1111/j.1467-7652.2008.00362.x.

André CM, Schafleitner R, Legay S, Lefèvre I, Aliaga CAA, Nomberto G, Hoffmann L, Hausman J, Larondelle Y, Evers D: Gene expression changes related to the production of phenolic compounds in potato tubers grown under drought stress. Phytochemistry. 2009, 70: 1107-1116. 10.1016/j.phytochem.2009.07.008.

Di Guardo M, Tadiello A, Farneti B, Lorenz G, Masuero D, Vrhovsek U, Costa G, Velasco R, Costa F: A multidisciplinary approach providing new insight into fruit flesh browning physiology in apple (Malus x domestica Borkh.). PLoS One 2013, 8:e78004.,

Urbany C, Stich B, Schmidt L, Simon L, Berding H, Junghans H, Niehoff KH, Braun A, Tacke E, Hofferbert HR, Lubeck J, Strahwald J, Gebhardt C: Association genetics in Solanum tuberosum provides new insights into potato tuber bruising and enzymatic tissue discoloration. BMC Genomics 2011, 12:7.,

Coetzer C, Corsini D, Love S, Pavek J, Tumer N: Control of enzymatic browning in potato (Solanum tuberosum L.) by sense and antisense RNA from tomato polyphenol oxidase. J Agric Food Chem. 2001, 49: 652-657. 10.1021/jf001217f.

Murata M, Nishimura M, Murai N, Haruta M, Homma S, Itoh Y: A transgenic apple callus showing reduced polyphenol oxidase activity and lower browning potential. Biosci Biotechnol Biochem. 2001, 65: 383-388. 10.1271/bbb.65.383.

Chai C, Lin Y, Shen D, Wu Y, Li H, Dou D: Identification and functional characterization of the Soybean GmaPPO12 promoter conferring Phytophthora sojae induced expression. PLoS One 2013, 8:e67670.,

Newman SM, Tantasawat P, Steffens JC: Tomato polyphenol oxidase B is spatially and temporally regulated during development and in response to ethylene. Molecules. 2011, 16: 493-517. 10.3390/molecules16010493.

Tran L, Taylor J, Constabel C: The polyphenol oxidase gene family in land plants: lineage-specific duplication and expansion. BMC Genomics 2012, 13:395.,

Yamakawa K, Mochizuki H: Nature and inheritance of Fusarium-wilt resistance in eggplant cultivars and related wild Solanum species. Bull Veg Orn Crops Res Stn. 1979, 6: 19-27.

Stàgel A, Portis E, Toppino L, Rotino GL, Lanteri S: Gene-based microsatellite development for mapping and phylogeny studies in eggplant. BMC Genomics 2008, 9:357.,

Frary A, Frary A, Daunay M, Huvenaars K, Mank R, Doğanlar S: QTL hotspots in eggplant (Solanum melongena) detected with a high resolution map and CIM analysis. Euphytica. 2014, 197: 211-228. 10.1007/s10681-013-1060-6.

Portis E, Barchi L, Toppino L, Lanteri S, Acciarri N, Felicioni N, Fusari F, Barbierato V, Cericola F, Valè G, Rotino GL: QTL Mapping in eggplant reveals clusters of yield-related loci and orthology with the tomato genome. PLoS One 2014, 9:e89499.,

Hirakawa H, Shirasawa K, Miyatake K, Nunome T, Negoro S, Ohyama A, Yamaguchi H, Sato S, Isobe S, Tabata S, Fukuoka H: Draft genome sequence of eggplant (Solanum melongena L.): the representative solanum species indigenous to the old world. DNA Res 2014, 1–12. doi:10.1093/dnares/dsu027,

Doyle J, Doyle J: A rapid DNA isolation procedure for small quantities of fresh leaf tissue. Phytochem Bull. 1987, 19: 11-15.

Wu F, Mueller LA, Crouzillat D, Pétiard V, Tanksley SD: Combining bioinformatics and phylogenetics to identify large sets of single-copy orthologous genes (COSII) for comparative, evolutionary and systematic studies: a test case in the euasterid plant clade. Genetics. 2006, 174: 1407-1420. 10.1534/genetics.106.062455.

Kofler R, Schlötterer C, Lelley T: SciRoKo: a new tool for whole genome microsatellite search and investigation. Bioinformatics. 2007, 23: 1683-1685. 10.1093/bioinformatics/btm157.

Bombarely A, Menda N, Tecle IY, Buels RM, Strickler S, Fischer-York T, Pujar A, Leto J, Gosselin J, Mueller LA: The Sol Genomics Network (solgenomics.net): growing tomatoes using Perl. Nucleic Acids Res. 2011, 39: D1149-D1155. 10.1093/nar/gkq866.

Vos P, Hogers R, Bleeker M, Reijans M, van De Lee T, Hornes M, Friters A, Pot J, Paleman J, Kuiper M: AFLP: a new technique for DNA fingerprinting. Nucleic Acids Res. 1995, 23: 4407-4414. 10.1093/nar/23.21.4407.

Hall TA: BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucleic Acids Symp Ser. 1999, 41: 95-98.

Rozen S, Skaletsky H: Primer3 on the WWW for general users and for biologist programmers. Bioinformatics Meth Protocols. 1999, 132: 365-386. 10.1385/1-59259-192-2:365.

Huang Z, Van Houten J, Gonzalez G, Xiao H, van der Knaap E: Genome-wide identification, phylogeny and expression analysis of SUN, OFP and YABBY gene family in tomato. Mol Genet Genomics. 2013, 288: 111-129. 10.1007/s00438-013-0733-0.

Van Ooijen J: JoinMap 4. Software for the calculation of genetic linkage maps in experimental populations. Kyazma BV, Wageningen, Netherlands. 2006

Kosambi D: The estimation of map distances from recombination values. Ann Eugen. 1944, 12: 172-175. 10.1111/j.1469-1809.1943.tb02321.x.

Krzywinski M, Schein J, Birol İ, Connors J, Gascoyne R, Horsman D, Jones SJ, Marra MA: Circos: an information aesthetic for comparative genomics. Genome Res. 2009, 19: 1639-1645. 10.1101/gr.092759.109.


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