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Improving the effectiveness of amiRNA-mediated resistance against Turnip mosaic virus by combining two amiRNAs or by targeting highly conserved viral genomic regions

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Improving the effectiveness of amiRNA-mediated resistance against Turnip mosaic virus by combining two amiRNAs or by targeting highly conserved viral genomic regions

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Lafforgue, G.; Martínez, F.; Niu, QW.; Chua, NH.; Daros Arnau, JA.; Elena Fito, SF. (2013). Improving the effectiveness of amiRNA-mediated resistance against Turnip mosaic virus by combining two amiRNAs or by targeting highly conserved viral genomic regions. Journal of Virology. 87(14):8254-8256. https://doi.org/10.1128/JVI.00914-13

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Título: Improving the effectiveness of amiRNA-mediated resistance against Turnip mosaic virus by combining two amiRNAs or by targeting highly conserved viral genomic regions
Autor: Lafforgue, Guillaume Martínez, Fernando Niu, Qi Wen Chua, Nam Hai Daros Arnau, Jose Antonio Elena Fito, Santiago Fco
Entidad UPV: Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes
Fecha difusión:
Resumen:
[EN] A drawback of recent antiviral therapies based on the transgenic expression of artificial microRNAs (amiRs) is the ease with which viruses generate escape mutations. Here, we show two alternative strategies for ...[+]
Palabras clave: RNA INTERFERENCE , ESCAPE , REPLICATION , INHIBITION , EXPRESSION
Derechos de uso: Reserva de todos los derechos
Fuente:
Journal of Virology. (issn: 0022-538X )
DOI: 10.1128/JVI.00914-13
Editorial:
American Society for Microbiology
Versión del editor: https://dx.doi.org/10.1128/JVI.00914-13
Código del Proyecto:
info:eu-repo/grantAgreement/GVA//PROMETEO%2F2010%2F019/ES/Implicaciones evolutivas de la supresión del silenciamiento del RNA por parte de proteína virales/
info:eu-repo/grantAgreement/HFSP//RGP0012%2F2008/
info:eu-repo/grantAgreement/MINECO//BFU2012-30805/ES/EVOLUTIONARY SYSTEMS VIROLOGY: EPISTASIS AND THE RUGGEDNESS OF ADAPTIVE LANDSCAPES, MUTATIONS IN REGULATORY SEQUENCES, AND THE HOST DETERMINANTS OF VIRAL FITNESS/
info:eu-repo/grantAgreement/CSIC//2010TW0015/ES/Evaluation of the durability of artificial microRNA-mediated strategies for plant resistance to RNA viruses/
info:eu-repo/grantAgreement/MICINN//BIO2011-26741/ES/PATOGENOS DE RNA DE PLANTAS: INTERACCION CON EL HUESPED Y DESARROLLO DE HERRAMIENTAS BIOTECNOLOGICAS/
Agradecimientos:
This work was supported by grants RGP12/2008 from the Human Frontier Science Program Organization, PROMETEO2010/019 from the Generalitat Valenciana, and BFU2012-30805 from the Spanish Ministerio de Economia y Competitividad ...[+]
Tipo: Artículo

References

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