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Improving the effectiveness of amiRNA-mediated resistance against Turnip mosaic virus by combining two amiRNAs or by targeting highly conserved viral genomic regions.

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Improving the effectiveness of amiRNA-mediated resistance against Turnip mosaic virus by combining two amiRNAs or by targeting highly conserved viral genomic regions.

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Lafforgue, G.; Martínez, F.; Niu, QW.; Chua, NH.; Daros Arnau, JA.; Elena Fito, SF. (2013). Improving the effectiveness of amiRNA-mediated resistance against Turnip mosaic virus by combining two amiRNAs or by targeting highly conserved viral genomic regions. Journal of Virology. 87(14):8254-8256. doi:10.1128/JVI.00914-13.

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Título: Improving the effectiveness of amiRNA-mediated resistance against Turnip mosaic virus by combining two amiRNAs or by targeting highly conserved viral genomic regions.
Autor:
Entidad UPV: Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes
Fecha difusión:
Resumen:
[EN] A drawback of recent antiviral therapies based on the transgenic expression of artificial microRNAs (amiRs) is the ease with which viruses generate escape mutations. Here, we show two alternative strategies for ...[+]
Palabras clave: RNA INTERFERENCE , ESCAPE , REPLICATION , INHIBITION , EXPRESSION
Derechos de uso: Reserva de todos los derechos
Fuente:
Journal of Virology. (issn: 0022-538X )
DOI: 10.1128/JVI.00914-13
Editorial:
American Society for Microbiology
Versión del editor: https://dx.doi.org/10.1128/JVI.00914-13
Patrocinador:
Human Frontier Science Program Organization RGP12/2008
Generalitat Valenciana PROMETEO2010/019
Spanish Ministerio de Economia y Competitividad (MINECO) BFU2012-30805
CSIC 2010TW0015
MINECO BIO2011-26741
Universidad Politecnica de Valencia
Tipo: Artículo

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