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Porous Polylactic Acid-Silica Hybrids: Preparation, Characterization, and Study of Mesenchymal Stem Cell Osteogenic Differentiation

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Porous Polylactic Acid-Silica Hybrids: Preparation, Characterization, and Study of Mesenchymal Stem Cell Osteogenic Differentiation

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dc.contributor.author Pandis, Christos es_ES
dc.contributor.author Trujillo Muñoz, Sara es_ES
dc.contributor.author Matos, Joana es_ES
dc.contributor.author Madeira, Sara es_ES
dc.contributor.author Ródenas Rochina, Joaquín es_ES
dc.contributor.author Kripotou, Sotiria es_ES
dc.contributor.author Kyritsis, Apostolos es_ES
dc.contributor.author Mano, Joao F. es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.date.accessioned 2016-05-10T11:28:05Z
dc.date.issued 2015-02
dc.identifier.issn 1616-5187
dc.identifier.uri http://hdl.handle.net/10251/63849
dc.description.abstract A novel approach to reinforce polymer porous membranes is presented. In the prepared hybrid materials, the inorganic phase of silica is synthesized in-situ and inside the pores of aminolyzed polylactic acid (PLA) membranes by sol-gel reactions using tetraethylorthosilicate (TEOS) and glycidoxypropyltrimethoxysilane (GPTMS) as precursors. The hybrid materials present a porous structure with a silica layer covering the walls of the pores while GPTMS serves also as coupling agent between the organic and inorganic phase. The adjustment of silica precursors ratio allows the modulation of the thermomechanical properties. Culture of mesenchymal stem cells on these supports in osteogenic medium shows the expression of characteristic osteoblastic markers and the mineralization of the extracellular matrix. es_ES
dc.description.sponsorship The research project is implemented within the framework of the Action "Supporting Postdoctoral Researchers" of the Operational Program "Education and Lifelong Learning'' (Action's Beneficiary: General Secretariat for Research and Technology), and is co-financed by the European Social Fund (ESF) and the Greek State, Grant No.: NARGEL-PE5(2551). J.R.R. acknowledges funding of his PhD by the Generalitat Valenciana through VALi+d grant (ACIF/2010/238). J.F.M. thanks the Portuguese Foundation for Science and Technology (FCT) for financial support through the PTDC/FIS/115048/2009 project. J.L.G.R. acknowledges the support of the Ministerio de Economia y Competitividad, MINECO, through theMAT2013-46467-C4-1-R project. CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with the assistance from the European Regional Development Fund. en_EN
dc.language Inglés es_ES
dc.publisher Wiley es_ES
dc.relation.ispartof Macromolecular Bioscience es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject organic-inorganic hybrid composites es_ES
dc.subject porosity es_ES
dc.subject proliferation and osteoblastic differentiation of cells es_ES
dc.subject sol-gel processes es_ES
dc.subject thermomechanical properties es_ES
dc.subject Differentiation of cells
dc.subject.classification INGENIERIA QUIMICA es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.subject.classification TERMODINAMICA APLICADA (UPV) es_ES
dc.title Porous Polylactic Acid-Silica Hybrids: Preparation, Characterization, and Study of Mesenchymal Stem Cell Osteogenic Differentiation es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1002/mabi.201400339
dc.relation.projectID info:eu-repo/grantAgreement/J4FCT/5876-PPCDTI/115048/PT/
dc.relation.projectID info:eu-repo/grantAgreement/GSRT//NARGEL-PE5 (2551)/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//ACIF%2F2010%2F238/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2013-46467-C4-1-R/ES/ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVA/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Química y Nuclear - Departament d'Enginyeria Química i Nuclear es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular es_ES
dc.description.bibliographicCitation Pandis, C.; Trujillo Muñoz, S.; Matos, J.; Madeira, S.; Ródenas Rochina, J.; Kripotou, S.; Kyritsis, A.... (2015). Porous Polylactic Acid-Silica Hybrids: Preparation, Characterization, and Study of Mesenchymal Stem Cell Osteogenic Differentiation. Macromolecular Bioscience. 15(2):262-274. https://doi.org/10.1002/mabi.201400339 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1002/mabi.201400339 es_ES
dc.description.upvformatpinicio 262 es_ES
dc.description.upvformatpfin 274 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 15 es_ES
dc.description.issue 2 es_ES
dc.relation.senia 300840 es_ES
dc.identifier.eissn 1616-5195
dc.contributor.funder Generalitat Valenciana
dc.contributor.funder Ministerio de Economía y Competitividad
dc.contributor.funder General Secretariat for Research and Technology, Grecia
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
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