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dc.contributor.author | Soler-Botija, Carolina | es_ES |
dc.contributor.author | Bago, Juli R. | es_ES |
dc.contributor.author | Llucia-Valldeperas, Aida | es_ES |
dc.contributor.author | Vallés Lluch, Ana | es_ES |
dc.contributor.author | Castells-Sala, Cristina | es_ES |
dc.contributor.author | Martinez-Ramos, Cristina | es_ES |
dc.contributor.author | Fernandez-Muinos, Teresa | es_ES |
dc.contributor.author | Chachques, Juan Carlos | es_ES |
dc.contributor.author | Monleón Pradas, Manuel | es_ES |
dc.contributor.author | Semino, Carlos E. | es_ES |
dc.contributor.author | Bayes-Genis, Antoni | es_ES |
dc.date.accessioned | 2016-05-12T07:39:19Z | |
dc.date.available | 2016-05-12T07:39:19Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1943-8141 | |
dc.identifier.uri | http://hdl.handle.net/10251/63949 | |
dc.description.abstract | [EN] Contractile restoration of myocardial scars remains a challenge with important clinical implications. Here, a combination of porous elastomeric membrane, peptide hydrogel, and subcutaneous adipose tissue-derived progenitor cells (subATDPCs) was designed and evaluated as a bioimplant for cardiac regeneration in a mouse model of myocardial infarction. SubATDPCs were doubly transduced with lentiviral vectors to express bioluminescent-fluorescent reporters driven by constitutively active, cardiac tissue-specific promoters. Cells were seeded into an engineered bioimplant consisting of a scaffold (polycaprolactone methacryloyloxyethyl ester) filled with a peptide hydrogel (PuraMatrix(TM)), and transplanted to cover injured myocardium. Bioluminescence and fluorescence quantifications showed de novo and progressive increases in promoter expression in bioactive implant-treated animals. The bioactive implant was well adapted to the heart, and fully functional vessels traversed the myocardium-bioactive implant interface. Treatment translated into a detectable positive effect on cardiac function, as revealed by echocardiography. Thus, this novel implant is a promising construct for supporting myocardial regeneration. | es_ES |
dc.description.sponsorship | The research leading to these results received funding from the European Union Seventh Framework Programme (Project RECATABI, 7FP/2007-2013) under grant agreement number 229239. This work was also supported by Ministerio de Ciencia e Innovación (SAF2011- 30067-C02-01), Fundació La Marató de TV3 (080330), Red de Terapia Celular-TerCel (RD12/0019/0029), Red Cardio-vascular (RD12/0042/0047), Sociedad Española de Cardiología, and Fundació Privada Daniel Bravo Andreu | |
dc.language | Inglés | es_ES |
dc.publisher | e-Century Publishing | es_ES |
dc.relation.ispartof | American Journal of Translational Research | es_ES |
dc.rights | Reconocimiento - No comercial (by-nc) | es_ES |
dc.subject | Cardiac regeneration | es_ES |
dc.subject | Subcutaneous ATDPCs | es_ES |
dc.subject | Self-assembling peptide hydrogel | es_ES |
dc.subject | Elastomeric membrane | es_ES |
dc.subject | RECATABI | es_ES |
dc.subject.classification | MAQUINAS Y MOTORES TERMICOS | es_ES |
dc.title | Engineered 3D bioimplants using elastomeric scaffold, self-assembling peptide hydrogel, and adipose tissue-derived progenitor cells for cardiac regeneration | es_ES |
dc.type | Artículo | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//SAF2011-30067-C02-01/ES/DESARROLLO DE BIOIMPLANTES PARA LA REGENERACION CARDIACA CON CELULAS PROGENITORAS DERIVADAS DE LA GRASA CARDIACA, BIOMATERIALES Y MONITORIZACION EN LINEA: EL "SMART PATCH"/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/229239/EU/Regeneration of Cardiac Tissue Assisted by Bioactive Implants/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/Fundació La Marató de TV3//080330/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//RD12%2F0019%2F0029/ES/Terapia Celular/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//RD12%2F0042%2F0047/ES/Enfermedades cardiovasculares/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular | es_ES |
dc.description.bibliographicCitation | Soler-Botija, C.; Bago, JR.; Llucia-Valldeperas, A.; Vallés Lluch, A.; Castells-Sala, C.; Martinez-Ramos, C.; Fernandez-Muinos, T.... (2014). Engineered 3D bioimplants using elastomeric scaffold, self-assembling peptide hydrogel, and adipose tissue-derived progenitor cells for cardiac regeneration. American Journal of Translational Research. 6:291-301. http://hdl.handle.net/10251/63949 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://www.ajtr.org/ | |
dc.description.upvformatpinicio | 291 | es_ES |
dc.description.upvformatpfin | 301 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 6 | es_ES |
dc.relation.senia | 279166 | es_ES |
dc.identifier.pmid | 24936221 | |
dc.identifier.pmcid | PMC4058310 | |
dc.contributor.funder | European Commission | |
dc.contributor.funder | Ministerio de Ciencia e Innovación | |
dc.contributor.funder | Fundació La Marató de TV3 | |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |