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Ceria nanoparticles with rhodamine B as a powerful theranostic agent against intracellular oxidative stress

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Ceria nanoparticles with rhodamine B as a powerful theranostic agent against intracellular oxidative stress

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dc.contributor.author Apostolova, Nadezda es_ES
dc.contributor.author Rovira-Llopis, Susana es_ES
dc.contributor.author Baldovi, Herme G. es_ES
dc.contributor.author Navalón Oltra, Sergio es_ES
dc.contributor.author Asiri, Abdullah M. es_ES
dc.contributor.author Victor, Victor M. es_ES
dc.contributor.author García Gómez, Hermenegildo es_ES
dc.contributor.author Herance Camacho, Jose Raul es_ES
dc.date.accessioned 2016-05-16T07:48:29Z
dc.date.available 2016-05-16T07:48:29Z
dc.date.issued 2015
dc.identifier.issn 2046-2069
dc.identifier.uri http://hdl.handle.net/10251/64100
dc.description.abstract Ceria nanoparticles with rhodamine B groups covalently attached on their surface (RhB-CeNPs) were successfully prepared to simultaneously exhibit antioxidant activity and the ability to detect oxidant species. In order to use them for biomedical purposes, the nanoparticles were internalized in two human cell lines (HeLa and Hep3B), confirmed by confocal microscopy. In addition, their biocompatibility was assessed by performing proliferation, viability and apoptosis assays, in which they showed a remarkable lack of toxicity. Thereafter, the antioxidant activity of RhB-CeNPs against reactive oxygen species (ROS) in a model of oxidative stress was demonstrated in HeLa cells using the dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay. RhB-CeNPs exhibited higher cytosolic antioxidant activity than the well-established ceria nanoparticles. Surprisingly, the antioxidant capacity of RhB-CeNPs was evident when the ROS content of the cells increased notably (and was, therefore, harmful for those cells). Furthermore, the ability of RhB-CeNPs as ROS-content sensors was evaluated by measuring oxidative stress in HeLa cells using the intrinsic fluorescence of the rhodamine B groups present on the nanoparticles. The results with respect to the detection and quantification of ROS were similar to those obtained with DCFH-DA, a typical method of quantifying intracellular ROS. Our results demonstrate the potential of RhB-CeNPs as remarkably biocompatible theranostic agents with application in the field of oxidative stress. es_ES
dc.description.sponsorship The present work was supported by the grant CP13/00252, PI13/1025 from Carlos III Health Institute, and by the European Regional Development Fund (ERDF). In addition, this study was financed by the Spanish Ministry of Economy and Competitiveness (Severo Ochoa and CTQ2012-32315), the Generalitat Valenciana (Prometeo 2012-013), Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (UGP-14-095) and supported by the Spanish Ministry of Science and Innovation. en_EN
dc.language Inglés es_ES
dc.publisher Royal Society of Chemistry es_ES
dc.relation.ispartof RSC Advances es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject OXIDE NANOPARTICLES es_ES
dc.subject NANOMEDICINE es_ES
dc.subject CELLS es_ES
dc.subject GOLD es_ES
dc.subject PHOTODEGRADATION es_ES
dc.subject LOCALIZATION es_ES
dc.subject PERSPECTIVES es_ES
dc.subject PROTECTION es_ES
dc.subject DISEASES es_ES
dc.subject THERAPY es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Ceria nanoparticles with rhodamine B as a powerful theranostic agent against intracellular oxidative stress es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1039/c5ra12794g
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CP13%2F00252/ES/CP13%2F00252/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CTQ2012-32315/ES/REDUCCION FOTOCATALITICA DEL DIOXIDO DE CARBONO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2012%2F013/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/FISABIO//UGP-14-095/ES/Disfunción endotelial-mitocondrial, estrés de retículo y autofagia en la diabetes tipo 2: Implicaciones, fisiopatologías, clínicas y terapéuticas/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química es_ES
dc.description.bibliographicCitation Apostolova, N.; Rovira-Llopis, S.; Baldovi, HG.; Navalón Oltra, S.; Asiri, AM.; Victor, VM.; García Gómez, H.... (2015). Ceria nanoparticles with rhodamine B as a powerful theranostic agent against intracellular oxidative stress. RSC Advances. 5(97):79423-79432. https://doi.org/10.1039/c5ra12794g es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1039/c5ra12794g es_ES
dc.description.upvformatpinicio 79423 es_ES
dc.description.upvformatpfin 79432 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 5 es_ES
dc.description.issue 97 es_ES
dc.relation.senia 305158 es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
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