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dc.contributor.author | Ferrer Albero, Ana![]() |
es_ES |
dc.contributor.author | Sebastián Aguilar, Rafael![]() |
es_ES |
dc.contributor.author | Sánchez Quintana, Damián![]() |
es_ES |
dc.contributor.author | Rodriguez, José F.![]() |
es_ES |
dc.contributor.author | Godoy, Eduardo Jorge![]() |
es_ES |
dc.contributor.author | Martinez, Laura![]() |
es_ES |
dc.contributor.author | Saiz Rodríguez, Francisco Javier![]() |
es_ES |
dc.date.accessioned | 2016-05-26T12:55:09Z | |
dc.date.available | 2016-05-26T12:55:09Z | |
dc.date.issued | 2015-11-02 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/10251/64804 | |
dc.description.abstract | Atrial arrhythmias, and specifically atrial fibrillation (AF), induce rapid and irregular activation patterns that appear on the torso surface as abnormal P-waves in electrocardiograms and body surface potential maps (BSPM). In recent years both P-waves and the BSPM have been used to identify the mechanisms underlying AF, such as localizing ectopic foci or high-frequency rotors. However, the relationship between the activation of the different areas of the atria and the characteristics of the BSPM and P-wave signals are still far from being completely understood. In this work we developed a multi-scale framework, which combines a highly-detailed 3D atrial model and a torso model to study the relationship between atrial activation and surface signals in sinus rhythm. Using this multi scale model, it was revealed that the best places for recording P-waves are the frontal upper right and the frontal and rear left quadrants of the torso. Our results also suggest that only nine regions (of the twenty-one structures in which the atrial surface was divided) make a significant contribution to the BSPM and determine the main P-wave characteristics. | es_ES |
dc.description.sponsorship | This work was partially supported by the "VI Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica" from the Ministerio de Economia y Competitividad of Spain and the European Commission (European Regional Development Funds - ERDF - FEDER), Award Number: TIN2012-37546-C03-01 (Recipient: Ana Ferrer); the "Programa Estatal de Investigacion, Desarrollo e Innovacion Orientado a los Retos de la Sociedad" from the Ministerio de Economia y Competitividad and the European Commission (European Regional Development Funds - ERDF - FEDER), Award Number: TIN2014-59932-JIN (Recipient: Rafael Sebastion); and the "Programa Prometeo" from the Generalitat Valenciana, Award Number: 2012/030 (Recipient: Laura Martinez). | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | Public Library of Science | es_ES |
dc.relation | "VI Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica" from the Ministerio de Economia y Competitividad of Spain | es_ES |
dc.relation | "Programa Estatal de Investigacion, Desarrollo e Innovacion Orientado a los Retos de la Sociedad" from the Ministerio de Economia y Competitividad | es_ES |
dc.relation.ispartof | PLoS ONE | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | BODY-SURFACE | es_ES |
dc.subject | P-WAVE | es_ES |
dc.subject | CONDUCTION-VELOCITY | es_ES |
dc.subject | SINUS RHYTHM | es_ES |
dc.subject | ACTION-POTENTIALS | es_ES |
dc.subject | VOLUME CONDUCTOR | es_ES |
dc.subject | RATE-DEPENDENCE | es_ES |
dc.subject | CANINE RIGHT | es_ES |
dc.subject | HUMAN HEART | es_ES |
dc.subject | FIBRILLATION | es_ES |
dc.subject.classification | TECNOLOGIA ELECTRONICA | es_ES |
dc.title | Detailed Anatomical and Electrophysiological Models of Human Atria and Torso for the Simulation of Atrial Activation | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0141573 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//TIN2014-59932-JIN/ES/CARACTERIZACION Y DIAGNOSTICO NO INVASIVO DE ARRITMIAS CARDIACAS MEDIANTE MODELADO COMPUTACIONAL 3D ANATOMO-FUNCIONAL DEL CORAZON Y TORSO HUMANO/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//PROMETEO%2F2012%2F030/ES/MEJORA EN LA PREVENCION Y TRATAMIENTO DE PATOLOGIAS CARDIACAS A TRAVES DE LA MODELIZACION MULTI-ESCALA Y LA SIMULACION COMPUTACIONAL (DIGITAL HEART)/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//TIN2012-37546-C03-01/ES/CORAZON HUMANO COMPLETO FISIOLOGICO VIRTUAL: MEJORAS EN EL TRATAMIENTO DE ARRITMIAS CARDIACAS ORIENTADO A PACIENTE/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica | es_ES |
dc.description.bibliographicCitation | Ferrer Albero, A.; Sebastián Aguilar, R.; Sánchez Quintana, D.; Rodriguez, JF.; Godoy, EJ.; Martinez, L.; Saiz Rodríguez, FJ. (2015). Detailed Anatomical and Electrophysiological Models of Human Atria and Torso for the Simulation of Atrial Activation. PLoS ONE. 10(11):1-29. https://doi.org/10.1371/journal.pone.0141573 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1371/journal.pone.0141573 | es_ES |
dc.description.upvformatpinicio | 1 | es_ES |
dc.description.upvformatpfin | 29 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 10 | es_ES |
dc.description.issue | 11 | es_ES |
dc.relation.senia | 297593 | es_ES |
dc.identifier.pmid | 26523732 | en_EN |
dc.identifier.pmcid | PMC4629897 | en_EN |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es_ES |