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Between Scylla and Charibdis: eIF2 alpha kinases as targets for cancer chemotherapy

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Between Scylla and Charibdis: eIF2 alpha kinases as targets for cancer chemotherapy

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Moreno Torres, M.; Murguía, JR. (2011). Between Scylla and Charibdis: eIF2 alpha kinases as targets for cancer chemotherapy. Clinical & Translational Oncology. 13(7):442-445. doi:10.1007/s12094-011-0680-3

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Title: Between Scylla and Charibdis: eIF2 alpha kinases as targets for cancer chemotherapy
Author:
UPV Unit: Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes
Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia
Issued date:
Abstract:
[EN] The eIF2 alpha kinases integrate translation initiation rates with nutrient availability, thus allowing cells to adapt to nutrient scarcity. Recent evidence has uncovered new functions of these kinases in tumour cell ...[+]
Subjects: eIF2 alpha phosphorylation , GCN2 , PERK , PKR , Translation
Copyrigths: Cerrado
Source:
Clinical & Translational Oncology. (issn: 1699-048X )
DOI: 10.1007/s12094-011-0680-3
Publisher:
Springer
Publisher version: https://dx.doi.org/10.1007/s12094-011-0680-3
Type: Artículo

References

Sonenberg N, Hinnebusch AG (2007) New modes of translational control in development, behavior, and disease. Mol Cell 28:721–729

Hinnebusch AG (2005) Translational regulation of GCN4 and the general amino acid control of yeast. Annu Rev Microbiol 59:407–450

Dever TE, Dar AC, Sicheri F (2007) The eIF2alpha kinases. In: Mathews MB, Sonenberg N, Hershey JWB (eds) Translational control in biology and medicine. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp 319–345 [+]
Sonenberg N, Hinnebusch AG (2007) New modes of translational control in development, behavior, and disease. Mol Cell 28:721–729

Hinnebusch AG (2005) Translational regulation of GCN4 and the general amino acid control of yeast. Annu Rev Microbiol 59:407–450

Dever TE, Dar AC, Sicheri F (2007) The eIF2alpha kinases. In: Mathews MB, Sonenberg N, Hershey JWB (eds) Translational control in biology and medicine. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp 319–345

Wang L, Liu Y, Wu S (2010) The roles of nitric oxide synthase and eIF2alpha kinases in regulation of cell cycle upon UVB-irradiation. Cell Cycle 9:38–42

Bouffant RL, Boulben S, Cormier P et al (2008) Inhibition of translation and modification of translation factors during apoptosis induced by the DNA-damaging agent MMS in sea urchin embryos. Exp Cell Res 314:961–968

Tvegard T, Soltani H, Skjolberg HC et al (2007) A novel checkpoint mechanism regulating the G1/S transition. Genes Dev 21:649–654

Menacho-Marquez M, Perez-Valle J, Arino J et al (2007) Gcn2p regulates a G1/S cell cycle checkpoint in response to DNA damage. Cell Cycle 6:2302–2305

Hamanaka RB, Bennett BS, Cullinan SB, Diehl JA (2005) PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway. Mol Biol Cell 16:5493–5501

Brewer JW, Diehl JA (2000) PERK mediates cellcycle exit during the mammalian unfolded protein response. Proc Natl Acad Sci U S A 97:12625–12630

Raven JF, Baltzis D, Wang S et al (2008) PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2alpha phosphorylation. J Biol Chem 283:3097–3108

Deng J, Harding HP, Raught B et al (2002) Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol 12:1279–1286

Jiang HY, Wek RC (2005) GCN2 phosphorylation of eIF2alpha activates NF-kappaB in response to UV irradiation. Biochem J 385:371–380

Rodriguez PC, Quiceno DG, Ochoa AC (2007) L-arginine availability regulates T-lymphocyte cell-cycle progression. Blood 109:1568–1573

Munn DH, Sharma MD, Baban B et al (2005) GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity 22:633–642

Usui T, Nagumo Y, Watanabe A et al (2006) Brasilicardin A, a natural immunosuppressant, targets amino acid transport system L. Chem Biol 13:1153–1160

Peidis P, Papadakis AI, Rajesh K, Koromilas AE (2010) HDAC pharmacological inhibition promotes cell death through the eIF2alpha kinases PKR and GCN2. Aging 2:669–677

Peidis P, Papadakis AI, Muaddi H et al (2010) Doxorubicin bypasses the cytoprotective effects of eIF2alpha phosphorylation and promotes PKR-mediated cell death. Cell Death Differ 18:145–154

Lou JJ, Chua YL, Chew EH et al (2010) Inhibition of hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis by DNA damage inducing agents. PloS one 5:e10522

Boyce M, Bryant KF, Jousse C et al (2005) A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science 307:935–939

Schewe DM, Aguirre-Ghiso JA (2009) Inhibition of eIF2alpha dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy. Cancer Res 69:1545–1552

Suzuki M, Endo M, Shinohara F et al (2009) Enhancement of cisplatin cytotoxicity by SAHA involves endoplasmic reticulum stress-mediated apoptosis in oral squamous cell carcinoma cells. Cancer Chemother Pharmacol 64:1115–1122

Sequeira SJ, Wen HC, Avivar-Valderas A et al (2009) Inhibition of eIF2alpha dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis. BMC Cell Biol 10:64

Monti E, Gariboldi MB (2011) HIF-1 as a target for cancer chemotherapy, chemosensitization and chemoprevention. Curr Mol Pharmacol 4:62–77

Zhang J, Cao J, Weng Q et al (2010) Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) by tirapazamine is dependent on eIF2alpha phosphorylation rather than the mTORC1/4E-BP1 pathway. PloS One 5:e13910

Ye J, Kumanova M, Hart LS et al (2010) The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. EMBO J 29:2082–2096

Wek RC, Jiang HY, Anthony TG (2006) Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans 34:7–11

Blais JD, Addison CL, Edge R et al (2006) Perkdependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress. Mol Cell Biol 26:9517–9532

Richards NG, Kilberg MS (2006) Asparagine synthetase chemotherapy. Annu Rev Biochem 75:629–654

Feng R, Zhai WL, Yang HY et al (2011) Induction of ER stress protects gastric cancer cells against apoptosis induced by cisplatin and doxorubicin through activation of p38 MAPK. Biochem Biophys Res Commun 406:299–304

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