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Between Scylla and Charibdis: eIF2 alpha kinases as targets for cancer chemotherapy

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Between Scylla and Charibdis: eIF2 alpha kinases as targets for cancer chemotherapy

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dc.contributor.author Moreno Torres, Marta es_ES
dc.contributor.author Murguía, Jose R. es_ES
dc.date.accessioned 2016-06-13T10:26:01Z
dc.date.available 2016-06-13T10:26:01Z
dc.date.issued 2011-07
dc.identifier.issn 1699-048X
dc.identifier.uri http://hdl.handle.net/10251/65736
dc.description.abstract [EN] The eIF2 alpha kinases integrate translation initiation rates with nutrient availability, thus allowing cells to adapt to nutrient scarcity. Recent evidence has uncovered new functions of these kinases in tumour cell biology, ranging from regulation of cell cycle progression, maintenance of genome stability, control of apoptosis, and cell survival under nutrient stress and hypoxia. Accordingly, active eIF2 alpha kinases modulate the antineoplasic activity of several antitumour drugs, either by exacerbating their cytotoxic effect or by promoting chemoresistance. Understanding of eIF2 alpha kinases molecular roles may provide mechanistic insights into how tumour cells sense and adapt to nutrient restriction, thus helping to implement more effective approaches for cancer chemotherapy. es_ES
dc.language Inglés es_ES
dc.publisher Springer es_ES
dc.relation.ispartof Clinical & Translational Oncology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject eIF2 alpha phosphorylation es_ES
dc.subject GCN2 es_ES
dc.subject PERK es_ES
dc.subject PKR es_ES
dc.subject Translation es_ES
dc.subject.classification BIOQUIMICA Y BIOLOGIA MOLECULAR es_ES
dc.title Between Scylla and Charibdis: eIF2 alpha kinases as targets for cancer chemotherapy es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s12094-011-0680-3
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia es_ES
dc.description.bibliographicCitation Moreno Torres, M.; Murguía, JR. (2011). Between Scylla and Charibdis: eIF2 alpha kinases as targets for cancer chemotherapy. Clinical & Translational Oncology. 13(7):442-445. doi:10.1007/s12094-011-0680-3 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://dx.doi.org/10.1007/s12094-011-0680-3 es_ES
dc.description.upvformatpinicio 442 es_ES
dc.description.upvformatpfin 445 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 13 es_ES
dc.description.issue 7 es_ES
dc.relation.senia 215016 es_ES
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