Rojas, S.; Domingo Gispert, J.; Abad Fuentes, S.; Buaki-Sogo, M.; Victor, VM.; García Gómez, H.; Herance Camacho, JR. (2012). In Vivo Biodistribution of Amino-Functionalized Ceria Nanoparticles in Rats Using Positron Emission Tomography. Molecular Pharmaceutics. 9(12):3543-3550. https://doi.org/10.1021/mp300382n
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/66726
Título:
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In Vivo Biodistribution of Amino-Functionalized Ceria Nanoparticles in Rats Using Positron Emission Tomography
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Autor:
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Rojas, Santiago
Domingo Gispert, Juan
Abad Fuentes, Sergio
Buaki-Sogo, Mireia
Victor, Victor M.
García Gómez, Hermenegildo
Herance Camacho, Jose Raul
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Entidad UPV:
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Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química
Universitat Politècnica de València. Departamento de Química - Departament de Química
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Fecha difusión:
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Resumen:
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A variety of nanoparticles have been proposed for several biomedical applications. To gauge the therapeutic potential of these nanoparticles, in vivo biodistribution is essential and mandatory. In the present study, ceria ...[+]
A variety of nanoparticles have been proposed for several biomedical applications. To gauge the therapeutic potential of these nanoparticles, in vivo biodistribution is essential and mandatory. In the present study, ceria nanoparticles (5 nm average particle size) were labeled with F-18 to study their in vivo biodistribution in rats by positron emission tomography (PET). The F-18 isotope was anchored by reaction of N-succinimidyl 4-[F-18]fluorobenzoate (F-18-SFB) with a modified nanoparticle surface obtained by silylation with 3-aminopropylsilyl. Radiolabeled ceria nanoparticles accumulated mainly in lungs, spleen, and liver. Metabolic products of the radiolabeled nanoparticulate material were excreted into the urinary tract.
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Palabras clave:
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ceria nanoparticles
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PET
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pharmacokinetics
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in vivo evaluation
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rodent
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Derechos de uso:
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Cerrado |
Fuente:
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Molecular Pharmaceutics. (issn:
1543-8384
)
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DOI:
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10.1021/mp300382n
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Editorial:
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American Chemical Society
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Versión del editor:
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http://dx.doi.org/10.1021/mp300382n
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Código del Proyecto:
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info:eu-repo/grantAgreement/MEC//CTQ2007-67805/ES/APLICACION DE NUEVOS DERIVADOS DEL PPV ENCAPSULADOS EN MATRICES DE SILICE EN LA PREPARACION DE TRANSISTORES DE CAMPO ELECTRICO Y RECTIFICADORES A ESCALA MICROMETRICA/
...[+]
info:eu-repo/grantAgreement/MEC//CTQ2007-67805/ES/APLICACION DE NUEVOS DERIVADOS DEL PPV ENCAPSULADOS EN MATRICES DE SILICE EN LA PREPARACION DE TRANSISTORES DE CAMPO ELECTRICO Y RECTIFICADORES A ESCALA MICROMETRICA/
info:eu-repo/grantAgreement/Fundació La Marató de TV3//090530/
info:eu-repo/grantAgreement/MICINN//PS09%2F02217/ES/VALORACION DEL POTENCIAL TERAPEUTICO DEL EVEROLIMUS EN UN MODELO DE ESCLEROSIS MULTIPLE. ESTUDIO MEDIANTE TOMOGRAFIA POR EMISION DE POSITRONES/
info:eu-repo/grantAgreement/ISCIII//CES10%2F030/
info:eu-repo/grantAgreement/GVA//ACOMP/2012/045/
info:eu-repo/grantAgreement/GVA//ACOMP%2F2012%2F045/
info:eu-repo/grantAgreement/La Marato Fundation//090530/
info:eu-repo/grantAgreement/Carlos III Health Institute//CES10%2F030/
info:eu-repo/grantAgreement/MICINN//PI10%2F01195/ES/Disfunción mitocondrial y diabetes tipo 2: Implicaciones patofisiológicas y clínicas/
info:eu-repo/grantAgreement/MICINN//PS09%2F02620/ES/ESTUDIO PET DE LOS PROCESOS FISIOPATOLOGICOS IMPLICADOS EN LA MUERTE NEURONAL SECUNDARIA EN LA HEMORRAGIA INTRAPARENQUIMATOSA Y LA ISQUEMIA CEREBRAL FOCAL/
info:eu-repo/grantAgreement/Generalitat Valenciana//AP-192%2F11/ES/Factores de riesgo cardiovascular en pacientes con Diabetes Mellitus tipo 2 y relación con la disfunción eréctil/
info:eu-repo/grantAgreement/MICINN//CTQ2009-11586/ES/ACTQ2009-11586/
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Agradecimientos:
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The present work was supported by the Spanish MICINN (Grants CTQ-2009-11586, CTQ2006-06785, and CTQ2007-67805-AR07, PI10/1195, AP192/11); the Fondo de Investigacion Sanitaria (FIS) of the Instituto de Salud Carlos III ...[+]
The present work was supported by the Spanish MICINN (Grants CTQ-2009-11586, CTQ2006-06785, and CTQ2007-67805-AR07, PI10/1195, AP192/11); the Fondo de Investigacion Sanitaria (FIS) of the Instituto de Salud Carlos III (Grants PS09/02620, PI10/1195, and PS09/02217), the Generalitat Valenciana (Grant ACOMP/2012/045), La Marato Fundation (Grant 090530), and by CDTI under the CENIT Programme (AMIT Project) and the Spanish Ministry of Science and Innovation. V.M.V. is a recipient of a contract from the Regional Ministry of Health of the Valencian Regional Government and Carlos III Health Institute (CES10/030).
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Tipo:
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Artículo
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