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Structure-activity relationship of dopaminergic halogenated 1-benzyl-tetrahydroisoquinoline derivatives

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Structure-activity relationship of dopaminergic halogenated 1-benzyl-tetrahydroisoquinoline derivatives

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El Aouad, N.; Berenguer, I.; Romero, V.; Marin, P.; Serrano, A.; Andujar, S.; Suvire, F.... (2009). Structure-activity relationship of dopaminergic halogenated 1-benzyl-tetrahydroisoquinoline derivatives. European Journal of Medicinal Chemistry. 44(11):4616-4621. doi:10.1016/j.ejmech.2009.06.033

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Title: Structure-activity relationship of dopaminergic halogenated 1-benzyl-tetrahydroisoquinoline derivatives
Author: El Aouad, Noureddine Berenguer, Inmaculada Romero, Vanessa Marin, Paloma Serrano, Angel Andujar, Sebastian Suvire, Fernando Bermejo, Almudena Ivorra, M. Dolores Enriz, Ricardo D. Cabedo Escrig, Nuria Cortes, Diego
UPV Unit: Universitat Politècnica de València. Instituto Agroforestal Mediterráneo - Institut Agroforestal Mediterrani
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Abstract:
Two series of halogenated 1-benzyl-7-chloro-6-hydroxy-tetrahydroisoquinolines were prepared to explore the influence of each series on the affinity for dopamine receptors. All the compounds displayed a high affinity for ...[+]
Subjects: 1-Halogenated benzyl-7-chloro-6-hydroxytetrahydroisoquinolines , Binding , Dopamine receptors , Dopamine uptak , Structure–activity relationships
Copyrigths: Cerrado
Source:
European Journal of Medicinal Chemistry. (issn: 0223-5234 )
DOI: 10.1016/j.ejmech.2009.06.033
Publisher:
Elsevier
Publisher version: http://dx.doi.org/10.1016/j.ejmech.2009.06.033
Thanks:
This research was supported by the Spanish "Ministerio de Educacion y Ciencia" grant SAF 2007-63142. I. Berenguer acknowledges the fellowship of Generalitat Valenciana. S. Andujar acknowledges the fellowship of CONICET-Argentina.[+]
Type: Artículo

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