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Structure-activity relationship of dopaminergic halogenated 1-benzyl-tetrahydroisoquinoline derivatives

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Structure-activity relationship of dopaminergic halogenated 1-benzyl-tetrahydroisoquinoline derivatives

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dc.contributor.author El Aouad, Noureddine es_ES
dc.contributor.author Berenguer, Inmaculada es_ES
dc.contributor.author Romero, Vanessa es_ES
dc.contributor.author Marin, Paloma es_ES
dc.contributor.author Serrano, Angel es_ES
dc.contributor.author Andujar, Sebastian es_ES
dc.contributor.author Suvire, Fernando es_ES
dc.contributor.author Bermejo, Almudena es_ES
dc.contributor.author Ivorra, M. Dolores es_ES
dc.contributor.author Enriz, Ricardo D. es_ES
dc.contributor.author Cabedo Escrig, Nuria es_ES
dc.contributor.author Cortes, Diego es_ES
dc.date.accessioned 2016-07-08T10:58:16Z
dc.date.available 2016-07-08T10:58:16Z
dc.date.issued 2009-11
dc.identifier.issn 0223-5234
dc.identifier.uri http://hdl.handle.net/10251/67377
dc.description.abstract Two series of halogenated 1-benzyl-7-chloro-6-hydroxy-tetrahydroisoquinolines were prepared to explore the influence of each series on the affinity for dopamine receptors. All the compounds displayed a high affinity for D(1)-like and/or D(2)-like dopamine receptors in striatal membranes, although they were unable to inhibit [(3)H]-dopamine uptake in striatal synaptosomes. The halogen placed on the benzylic ring in 1-benzyl-THIQs, compounds of the series 1, 2'-bromobenzyl derivatives with K(i) values into the nanomolar range, and the series 2, 2',4'-dichlorobenzyl-THIQ homologues, proves to be an important factor to modulate affinity at dopamine receptor. (C) 2009 Elsevier Masson SAS. All rights reserved. es_ES
dc.description.sponsorship This research was supported by the Spanish "Ministerio de Educacion y Ciencia" grant SAF 2007-63142. I. Berenguer acknowledges the fellowship of Generalitat Valenciana. S. Andujar acknowledges the fellowship of CONICET-Argentina. en_EN
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation Spanish "Ministerio de Educacion y Ciencia" SAF 2007-63142 es_ES
dc.relation Generalitat Valenciana es_ES
dc.relation CONICET-Argentina es_ES
dc.relation.ispartof European Journal of Medicinal Chemistry es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject 1-Halogenated benzyl-7-chloro-6-hydroxytetrahydroisoquinolines es_ES
dc.subject Binding es_ES
dc.subject Dopamine receptors es_ES
dc.subject Dopamine uptak es_ES
dc.subject Structure–activity relationships es_ES
dc.title Structure-activity relationship of dopaminergic halogenated 1-benzyl-tetrahydroisoquinoline derivatives es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.ejmech.2009.06.033
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Agroforestal Mediterráneo - Institut Agroforestal Mediterrani es_ES
dc.description.bibliographicCitation El Aouad, N.; Berenguer, I.; Romero, V.; Marin, P.; Serrano, A.; Andujar, S.; Suvire, F.... (2009). Structure-activity relationship of dopaminergic halogenated 1-benzyl-tetrahydroisoquinoline derivatives. European Journal of Medicinal Chemistry. 44(11):4616-4621. doi:10.1016/j.ejmech.2009.06.033 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.ejmech.2009.06.033 es_ES
dc.description.upvformatpinicio 4616 es_ES
dc.description.upvformatpfin 4621 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 44 es_ES
dc.description.issue 11 es_ES
dc.relation.senia 38606 es_ES


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