- -

Combinatorial Analysis of Secretory Immunoglobulin A (sIgA) Expression in Plants

RiuNet: Institutional repository of the Polithecnic University of Valencia

Share/Send to

Cited by


  • Estadisticas de Uso

Combinatorial Analysis of Secretory Immunoglobulin A (sIgA) Expression in Plants

Show full item record

Juárez Ortega, P.; Huet Trujillo, E.; Sarrion-Perdigones, A.; Falconi, E.; Granell Richart, A.; Orzáez Calatayud, DV. (2013). Combinatorial Analysis of Secretory Immunoglobulin A (sIgA) Expression in Plants. International Journal of Molecular Sciences. 14(3):6205-6222. https://doi.org/10.3390/ijms14036205

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/67693

Files in this item

Item Metadata

Title: Combinatorial Analysis of Secretory Immunoglobulin A (sIgA) Expression in Plants
Author: Juárez Ortega, Paloma Huet Trujillo, Estefanía Sarrion-Perdigones, Alejandro Falconi, E.E. Granell Richart, Antonio Orzáez Calatayud, Diego Vicente
UPV Unit: Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia
Issued date:
Delivery of secretory immunoglobulin A (sIgA) to mucosal surfaces as a passive immunotherapy agent is a promising strategy to prevent infectious diseases. Recombinant sIgA production in plants requires the co-expression ...[+]
Subjects: Secretory IgA , Antibody , Rotavirus , GoldenBraid , Plant synthetic biology
Copyrigths: Reconocimiento (by)
International Journal of Molecular Sciences. (issn: 1422-0067 )
DOI: 10.3390/ijms14036205
Publisher version: http://dx.doi.org/10.3390/ijms14036205
Project ID:
This work has been funded by Grant BIO2010-15384 from Plan Nacional I + D of the Spanish Ministry of Science. Juarez P. is a recipient of a FPU fellowship, and Sarrion-Perdigones A. and Huet-Trujillo E. are recipients of ...[+]
Type: Artículo


Reichert, J. M., & Valge-Archer, V. E. (2007). Development trends for monoclonal antibody cancer therapeutics. Nature Reviews Drug Discovery, 6(5), 349-356. doi:10.1038/nrd2241

Corthésy, B. (2010). Role of secretory immunoglobulin A and secretory component in the protection of mucosal surfaces. Future Microbiology, 5(5), 817-829. doi:10.2217/fmb.10.39

Corthésy, B. (2003). Recombinant Secretory Immunoglobulin A in Passive Immunotherapy: Linking Immunology and Biotechnology. Current Pharmaceutical Biotechnology, 4(1), 51-67. doi:10.2174/1389201033378020 [+]
Reichert, J. M., & Valge-Archer, V. E. (2007). Development trends for monoclonal antibody cancer therapeutics. Nature Reviews Drug Discovery, 6(5), 349-356. doi:10.1038/nrd2241

Corthésy, B. (2010). Role of secretory immunoglobulin A and secretory component in the protection of mucosal surfaces. Future Microbiology, 5(5), 817-829. doi:10.2217/fmb.10.39

Corthésy, B. (2003). Recombinant Secretory Immunoglobulin A in Passive Immunotherapy: Linking Immunology and Biotechnology. Current Pharmaceutical Biotechnology, 4(1), 51-67. doi:10.2174/1389201033378020

Corthësy, B. (2008). Secretory immunoglobulin A: well beyond immune exclusion at mucosal surfaces. Immunopharmacology and Immunotoxicology, 31(2), 174-179. doi:10.1080/08923970802438441

Sarrion-Perdigones, A., Juarez, P., Granell, A., & Orzaez, D. (2011). Production of Antibodies in Plants. Cell Engineering, 143-164. doi:10.1007/978-94-007-1257-7_7

Paul, M., Dolleweerd, C. van, Drake, P. M. W., Reljic, R., Thangaraj, H., Barbi, T., … Ma, J. K.-C. (2011). Molecular pharming. Human Vaccines, 7(3), 375-382. doi:10.4161/hv.7.3.14456

Fischer, R., Stoger, E., Schillberg, S., Christou, P., & Twyman, R. M. (2004). Plant-based production of biopharmaceuticals. Current Opinion in Plant Biology, 7(2), 152-158. doi:10.1016/j.pbi.2004.01.007

Twyman, R. M., Stoger, E., Schillberg, S., Christou, P., & Fischer, R. (2003). Molecular farming in plants: host systems and expression technology. Trends in Biotechnology, 21(12), 570-578. doi:10.1016/j.tibtech.2003.10.002

Saint-Jore-Dupas, C., Faye, L., & Gomord, V. (2007). From planta to pharma with glycosylation in the toolbox. Trends in Biotechnology, 25(7), 317-323. doi:10.1016/j.tibtech.2007.04.008

Ma, J., Hiatt, A., Hein, M., Vine, N., Wang, F., Stabila, P., … Lehner, T. (1995). Generation and assembly of secretory antibodies in plants. Science, 268(5211), 716-719. doi:10.1126/science.7732380

Ma, J. K.-C., Hikmat, B. Y., Wycoff, K., Vine, N. D., Chargelegue, D., Yu, L., … Lehner, T. (1998). Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in humans. Nature Medicine, 4(5), 601-606. doi:10.1038/nm0598-601

Weintraub, J. A., Hilton, J. F., White, J. M., Hoover, C. I., Wycoff, K. L., Yu, L., … Featherstone, J. D. B. (2005). Clinical Trial of a Plant-Derived Antibody on Recolonization of Mutans Streptococci. Caries Research, 39(3), 241-250. doi:10.1159/000084805

Wycoff, K. (2005). Secretory IgA Antibodies from Plants. Current Pharmaceutical Design, 11(19), 2429-2437. doi:10.2174/1381612054367508

Nicholson, L., Gonzalez-Melendi, P., Van Dolleweerd, C., Tuck, H., Perrin, Y., Ma, J. K.-C., … Stoger, E. (2004). A recombinant multimeric immunoglobulin expressed in rice shows assembly-dependent subcellular localization in endosperm cells. Plant Biotechnology Journal, 3(1), 115-127. doi:10.1111/j.1467-7652.2004.00106.x

Wieland, W. H., Lammers, A., Schots, A., & Orzáez, D. V. (2006). Plant expression of chicken secretory antibodies derived from combinatorial libraries. Journal of Biotechnology, 122(3), 382-391. doi:10.1016/j.jbiotec.2005.12.020

Larrick, J. W., Yu, L., Naftzger, C., Jaiswal, S., & Wycoff, K. (2001). Production of secretory IgA antibodies in plants. Biomolecular Engineering, 18(3), 87-94. doi:10.1016/s1389-0344(01)00102-2

FOLEY, R. C., RAISONS, R. L., & BEH, K. J. (1991). Monoclonal Antibody Against Sheep Kappa Light Chain. Hybridoma, 10(4), 507-515. doi:10.1089/hyb.1991.10.507

Furtado, P. B., Whitty, P. W., Robertson, A., Eaton, J. T., Almogren, A., Kerr, M. A., … Perkins, S. J. (2004). Solution Structure Determination of Monomeric Human IgA2 by X-ray and Neutron Scattering, Analytical Ultracentrifugation and Constrained Modelling: A Comparison with Monomeric Human IgA1. Journal of Molecular Biology, 338(5), 921-941. doi:10.1016/j.jmb.2004.03.007

De Muynck, B., Navarre, C., & Boutry, M. (2010). Production of antibodies in plants: status after twenty years. Plant Biotechnology Journal, 8(5), 529-563. doi:10.1111/j.1467-7652.2009.00494.x

Ma, J. K.-C., Drake, P. M. W., & Christou, P. (2003). The production of recombinant pharmaceutical proteins in plants. Nature Reviews Genetics, 4(10), 794-805. doi:10.1038/nrg1177

De Muynck, B., Navarre, C., Nizet, Y., Stadlmann, J., & Boutry, M. (2009). Different subcellular localization and glycosylation for a functional antibody expressed in Nicotiana tabacum plants and suspension cells. Transgenic Research, 18(3), 467-482. doi:10.1007/s11248-008-9240-1

D�ring, K., Hippe, S., Kreuzaler, F., & Schell, J. (1990). Synthesis and self-assembly of a functional monoclonal antibody in transgenic Nicotiana tabacum. Plant Molecular Biology, 15(2), 281-293. doi:10.1007/bf00036914

Wilde, C. D., Rycke, R. D., Beeckman, T., Neve, M. D., Montagu, M. V., Engler, G., & Depicker, A. (1998). Accumulation Pattern of IgG Antibodies and Fab Fragments in Transgenic Arabidopsis thaliana Plants. Plant and Cell Physiology, 39(6), 639-646. doi:10.1093/oxfordjournals.pcp.a029416

Schouten, A., Roosien, J., van Engelen, F. A., (Ineke) de Jong, G. A. M., (Tanja) Borst-Vrenssen, A. W. M., Zilverentant, J. F., … Bakker, J. (1996). The C-terminal KDEL sequence increases the expression level of a single-chain antibody designed to be targeted to both the cytosol and the secretory pathway in transgenic tobacco. Plant Molecular Biology, 30(4), 781-793. doi:10.1007/bf00019011

Bencurova, M. (2004). Specificity of IgG and IgE antibodies against plant and insect glycoprotein glycans determined with artificial glycoforms of human transferrin. Glycobiology, 14(5), 457-466. doi:10.1093/glycob/cwh058

Gomord, V., Fitchette, A.-C., Menu-Bouaouiche, L., Saint-Jore-Dupas, C., Plasson, C., Michaud, D., & Faye, L. (2010). Plant-specific glycosylation patterns in the context of therapeutic protein production. Plant Biotechnology Journal, 8(5), 564-587. doi:10.1111/j.1467-7652.2009.00497.x

Sarrion-Perdigones, A., Falconi, E. E., Zandalinas, S. I., Juárez, P., Fernández-del-Carmen, A., Granell, A., & Orzaez, D. (2011). GoldenBraid: An Iterative Cloning System for Standardized Assembly of Reusable Genetic Modules. PLoS ONE, 6(7), e21622. doi:10.1371/journal.pone.0021622

Weber, E., Engler, C., Gruetzner, R., Werner, S., & Marillonnet, S. (2011). A Modular Cloning System for Standardized Assembly of Multigene Constructs. PLoS ONE, 6(2), e16765. doi:10.1371/journal.pone.0016765

Monedero, V., Rodriguez-Diaz, J., Viana, R., Buesa, J., & Perez-Martinez, G. (2004). Selection of Single-Chain Antibodies against the VP8* Subunit of Rotavirus VP4 Outer Capsid Protein and Their Expression in Lactobacillus casei. Applied and Environmental Microbiology, 70(11), 6936-6939. doi:10.1128/aem.70.11.6936-6939.2004

Juárez, P., Presa, S., Espí, J., Pineda, B., Antón, M. T., Moreno, V., … Orzaez, D. (2011). Neutralizing antibodies against rotavirus produced in transgenically labelled purple tomatoes. Plant Biotechnology Journal, 10(3), 341-352. doi:10.1111/j.1467-7652.2011.00666.x

Langley, R., Wines, B., Willoughby, N., Basu, I., Proft, T., & Fraser, J. D. (2005). The Staphylococcal Superantigen-Like Protein 7 Binds IgA and Complement C5 and Inhibits IgA-FcαRI Binding and Serum Killing of Bacteria. The Journal of Immunology, 174(5), 2926-2933. doi:10.4049/jimmunol.174.5.2926

Sack, M., Paetz, A., Kunert, R., Bomble, M., Hesse, F., Stiegler, G., … Rademacher, T. (2007). Functional analysis of the broadly neutralizing human anti-HIV-1 antibody 2F5 produced in transgenic BY-2 suspension cultures. The FASEB Journal, 21(8), 1655-1664. doi:10.1096/fj.06-5863com

Ramessar, K., Rademacher, T., Sack, M., Stadlmann, J., Platis, D., Stiegler, G., … Christou, P. (2008). Cost-effective production of a vaginal protein microbicide to prevent HIV transmission. Proceedings of the National Academy of Sciences, 105(10), 3727-3732. doi:10.1073/pnas.0708841104

Brandtzaeg, P., & Prydz, H. (1984). Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins. Nature, 311(5981), 71-73. doi:10.1038/311071a0

Johansen, Braathen, & Brandtzaeg. (2000). Role of J Chain in Secretory Immunoglobulin Formation. Scandinavian Journal of Immunology, 52(3), 240-248. doi:10.1046/j.1365-3083.2000.00790.x

Braathen, R., Hohman, V. S., Brandtzaeg, P., & Johansen, F.-E. (2007). Secretory Antibody Formation: Conserved Binding Interactions between J Chain and Polymeric Ig Receptor from Humans and Amphibians. The Journal of Immunology, 178(3), 1589-1597. doi:10.4049/jimmunol.178.3.1589

Murthy, A. K., Chaganty, B. K. R., Troutman, T., Guentzel, M. N., Yu, J.-J., Ali, S. K., … Arulanandam, B. P. (2011). Mannose-Containing Oligosaccharides of Non-Specific Human Secretory Immunoglobulin A Mediate Inhibition of Vibrio cholerae Biofilm Formation. PLoS ONE, 6(2), e16847. doi:10.1371/journal.pone.0016847

Mathias, A., & Corthésy, B. (2011). N-Glycans on secretory component. Gut Microbes, 2(5), 287-293. doi:10.4161/gmic.2.5.18269

Hu, L., Crawford, S. E., Czako, R., Cortes-Penfield, N. W., Smith, D. F., Le Pendu, J., … Prasad, B. V. V. (2012). Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen. Nature, 485(7397), 256-259. doi:10.1038/nature10996

Yu, X., Dang, V. T., Fleming, F. E., von Itzstein, M., Coulson, B. S., & Blanchard, H. (2012). Structural Basis of Rotavirus Strain Preference toward N-Acetyl- or N-Glycolylneuraminic Acid-Containing Receptors. Journal of Virology, 86(24), 13456-13466. doi:10.1128/jvi.06975-11

Haselhorst, T., Fleming, F. E., Dyason, J. C., Hartnell, R. D., Yu, X., Holloway, G., … von Itzstein, M. (2008). Sialic acid dependence in rotavirus host cell invasion. Nature Chemical Biology, 5(2), 91-93. doi:10.1038/nchembio.134

Bonner, A., Almogren, A., Furtado, P. B., Kerr, M. A., & Perkins, S. J. (2008). The Nonplanar Secretory IgA2 and Near Planar Secretory IgA1 Solution Structures Rationalize Their Different Mucosal Immune Responses. Journal of Biological Chemistry, 284(8), 5077-5087. doi:10.1074/jbc.m807529200

Yoo, E. M., & Morrison, S. L. (2005). IgA: An immune glycoprotein. Clinical Immunology, 116(1), 3-10. doi:10.1016/j.clim.2005.03.010

Karnoup, A. S., Turkelson, V., & Anderson, W. H. K. (2005). O-Linked glycosylation in maize-expressed human IgA1. Glycobiology, 15(10), 965-981. doi:10.1093/glycob/cwi077

Ramsland, P. A., Willoughby, N., Trist, H. M., Farrugia, W., Hogarth, P. M., Fraser, J. D., & Wines, B. D. (2007). Structural basis for evasion of IgA immunity by Staphylococcus aureus revealed in the complex of SSL7 with Fc of human IgA1. Proceedings of the National Academy of Sciences, 104(38), 15051-15056. doi:10.1073/pnas.0706028104

Almogren, A., Senior, B. W., & Kerr, M. A. (2007). A comparison of the binding of secretory component to immunoglobulin A (IgA) in human colostral S-IgA1 and S-IgA2. Immunology, 120(2), 273-280. doi:10.1111/j.1365-2567.2006.02498.x

Orzaez, D., Mirabel, S., Wieland, W. H., & Granell, A. (2006). Agroinjection of Tomato Fruits. A Tool for Rapid Functional Analysis of Transgenes Directly in Fruit. Plant Physiology, 140(1), 3-11. doi:10.1104/pp.105.068221




This item appears in the following Collection(s)

Show full item record