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Recent Positive Selection Has Acted on Genes Encoding Proteins with More Interactions within the Whole Human Interactome

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Recent Positive Selection Has Acted on Genes Encoding Proteins with More Interactions within the Whole Human Interactome

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Luisi, P.; Alvarez-Ponce, D.; Pybus, M.; Fares Riaño, MA.; Bertranpetit, J.; Laayouni, H. (2015). Recent Positive Selection Has Acted on Genes Encoding Proteins with More Interactions within the Whole Human Interactome. Genome Biology and Evolution. 7(4):1141-1154. doi:10.1093/gbe/evv055

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Título: Recent Positive Selection Has Acted on Genes Encoding Proteins with More Interactions within the Whole Human Interactome
Autor:
Entidad UPV: Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes
Fecha difusión:
Resumen:
Genes vary in their likelihood to undergo adaptive evolution. The genomic factors that determine adaptability, however, remain poorly understood. Genes function in the context of molecular networks, with some occupying ...[+]
Palabras clave: Physical protein interaction , Protein interaction network , Natural selection , Positive selection , Mammals , Humans
Derechos de uso: Reserva de todos los derechos
Fuente:
Genome Biology and Evolution. (issn: 1759-6653 )
DOI: 10.1093/gbe/evv055
Editorial:
Oxford University Press (OUP)
Versión del editor: http://dx.doi.org/10.1093/gbe/evv055
Agradecimientos:
The authors thankfully acknowledge valuable discussion and corrections from Diego A. Hartasanchez, David A. Hughes, Jessica Nye, and Arcadi Navarro. They thank Gabriel Santpere for his help to compute the McDonald-Krietman ...[+]
Tipo: Artículo

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