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Recent Positive Selection Has Acted on Genes Encoding Proteins with More Interactions within the Whole Human Interactome

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Recent Positive Selection Has Acted on Genes Encoding Proteins with More Interactions within the Whole Human Interactome

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Luisi, P.; Alvarez-Ponce, D.; Pybus, M.; Fares Riaño, MA.; Bertranpetit, J.; Laayouni, H. (2015). Recent Positive Selection Has Acted on Genes Encoding Proteins with More Interactions within the Whole Human Interactome. Genome Biology and Evolution. 7(4):1141-1154. https://doi.org/10.1093/gbe/evv055

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Title: Recent Positive Selection Has Acted on Genes Encoding Proteins with More Interactions within the Whole Human Interactome
Author: Luisi, P Alvarez-Ponce, D Pybus, M Fares Riaño, Mario Ali Bertranpetit, J Laayouni, H
UPV Unit: Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes
Issued date:
Abstract:
Genes vary in their likelihood to undergo adaptive evolution. The genomic factors that determine adaptability, however, remain poorly understood. Genes function in the context of molecular networks, with some occupying ...[+]
Subjects: Physical protein interaction , Protein interaction network , Natural selection , Positive selection , Mammals , Humans
Copyrigths: Reserva de todos los derechos
Source:
Genome Biology and Evolution. (issn: 1759-6653 )
DOI: 10.1093/gbe/evv055
Publisher:
Oxford University Press (OUP)
Publisher version: http://dx.doi.org/10.1093/gbe/evv055
Project ID:
info:eu-repo/grantAgreement/SFI/SFI Investigator Programme/12/IP/1673/IE/
The authors thankfully acknowledge valuable discussion and corrections from Diego A. Hartasanchez, David A. Hughes, Jessica Nye, and Arcadi Navarro. They thank Gabriel Santpere for his help to compute the McDonald-Krietman test. They also thank the National Institute of Bioinformatics (http://www.inab.org) and Javier Forment, from the Bioinformatics service at the "Instituto de Biologia Molecular y Celular de Plantas," for computational support. This work was funded by the "Ministerio de Ciencia y Tecnologia" (Spain) (grant BFU2013-43726-P), and the "Direccio General de Recerca, Generalitat de Catalunya (Grup de Recerca Consolidat 2009 SGR 1101)" awarded to J.B. P.L. was supported by a Ph.D. fellowship from "Accion Estrategica de Salud, en el marco del Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica 2008-2011" from Instituto de Salud Carlos III. D.A.-P. was a "Juan de la Cierva" fellow from the "Ministerio de Economia y Competitividad" (Spain) (JCI-2011-11089). M.A.F. was supported by a Principal Investigator grant from Science Foundation Ireland (12/IP/1673) and a project from the "Ministerio de Economia y Competitividad" (grant number BFU2012-36346).
Thanks:
The authors thankfully acknowledge valuable discussion and corrections from Diego A. Hartasanchez, David A. Hughes, Jessica Nye, and Arcadi Navarro. They thank Gabriel Santpere for his help to compute the McDonald-Krietman ...[+]
Type: Artículo

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