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Bactericidal activity of caprylic acid entrapped in mesoporous silica nanoparticles

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Bactericidal activity of caprylic acid entrapped in mesoporous silica nanoparticles

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dc.contributor.author Ruiz Rico, María es_ES
dc.contributor.author Fuentes López, Cristina es_ES
dc.contributor.author Pérez-Esteve, Édgar es_ES
dc.contributor.author Jiménez Belenguer, Ana Isabel es_ES
dc.contributor.author Quiles Chuliá, Mª Desamparados es_ES
dc.contributor.author Marcos Martínez, María Dolores es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.contributor.author Barat Baviera, José Manuel es_ES
dc.date.accessioned 2016-07-29T12:17:27Z
dc.date.available 2016-07-29T12:17:27Z
dc.date.issued 2015-10
dc.identifier.issn 0956-7135
dc.identifier.uri http://hdl.handle.net/10251/68452
dc.description.abstract [EN] Development of nanotechnologies to improve the functionality of natural antimicrobials for food applications has received much attention in recent years. Mesoporous silica particles, such as MCM-41, have been recently proposed as smart delivery devices capable of loading and releasing large amounts of cargo. In this study, the antimicrobial activity of caprylic acid entrapped in MCM-41 nanoparticles against Escherichia coli, Salmonella enterica, Staphylococcus aureus and Listeria monocytogenes was tested and compared with the bactericidal effect of free caprylic acid using the macrodilution method. The minimum bactericidal concentration for free caprylic acid was established to be below 18.5 mM for S. aureus and L. monocytogenes and within the 18.5-20 mM range for E. coli and S. enterica. Moreover, caprylic acid loaded nanoparticles showed a total inhibition of the growth within the 18.5-20 mM range for the tested bacteria, and therefore the antimicrobial activity was preserved. Transmission electron microscopy images revealed that bacteria treatment with the caprylic acid-loaded nanoparticles generated disruption of cell envelope and leakage of cytoplasmic content, which resulted in cell death. We believe that caprylic acid encapsulation in nanoparticles MCM-41 can provide an effective system for potential applications in food safety in the food industry due to the possible controlled release of fatty acid and the masking of its unpleasant organoleptic properties. (C) 2015 Elsevier Ltd. All rights reserved es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Food Control es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Caprylic acid-loaded nanoparticles es_ES
dc.subject Antimicrobial activity es_ES
dc.subject Minimum bactericidal concentration es_ES
dc.subject Encapsulation es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification MICROBIOLOGIA es_ES
dc.subject.classification TECNOLOGIA DE ALIMENTOS es_ES
dc.subject.classification INGENIERIA DE LA CONSTRUCCION es_ES
dc.title Bactericidal activity of caprylic acid entrapped in mesoporous silica nanoparticles es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.foodcont.2015.03.016
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Tecnología de Alimentos - Departament de Tecnologia d'Aliments es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Ruiz Rico, M.; Fuentes López, C.; Pérez-Esteve, É.; Jiménez Belenguer, AI.; Quiles Chuliá, MD.; Marcos Martínez, MD.; Martínez-Máñez, R.... (2015). Bactericidal activity of caprylic acid entrapped in mesoporous silica nanoparticles. Food Control. 56:77-85. doi:10.1016/j.foodcont.2015.03.016 es_ES
dc.description.accrualMethod Senia es_ES
dc.relation.publisherversion https://dx.doi.org/10.1016/j.foodcont.2015.03.016 es_ES
dc.description.upvformatpinicio 77 es_ES
dc.description.upvformatpfin 85 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 56 es_ES
dc.relation.senia 289153 es_ES


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