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Carbon-11 Radiolabelling of Organosulfur Compounds: 11C Synthesis of the Progesterone Receptor Agonist Tanaproget

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Carbon-11 Radiolabelling of Organosulfur Compounds: 11C Synthesis of the Progesterone Receptor Agonist Tanaproget

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dc.contributor.author Haywood, Tom es_ES
dc.contributor.author Kealey, Steven es_ES
dc.contributor.author Sánchez-Cabezas, Santiago es_ES
dc.contributor.author Hall, James J. es_ES
dc.contributor.author Allott, Louis es_ES
dc.contributor.author Smith, Graham es_ES
dc.contributor.author Plisson, Christophe es_ES
dc.contributor.author Miller, Philip W. es_ES
dc.date.accessioned 2016-09-28T06:40:33Z
dc.date.available 2016-09-28T06:40:33Z
dc.date.issued 2015-05-12
dc.identifier.issn 0947-6539
dc.identifier.uri http://hdl.handle.net/10251/70521
dc.description.abstract [EN] Herein a new 11C radiolabelling strategy for the fast and efficient synthesis of thioureas and related derivatives using the novel synthon, 11CS2, is reported. This approach has enabled the facile labelling of a potent progesterone receptor (PR) agonist, [11C]Tanaproget, by the intramolecular reaction of the acyclic aminohydroxyl precursor with 11CS2, which has potential applications as a positron emission tomography radioligand for cancer imaging. es_ES
dc.description.sponsorship We are grateful to the EPSRC (grant no. EP/L025140/1), The Royal Society (grant no. RG110449) and to the Imperial College-EPSRC Kick-Start programme for supporting this work.
dc.language Inglés es_ES
dc.publisher Wiley es_ES
dc.relation.ispartof Chemistry - A European Journal es_ES
dc.rights Reserva de todos los derechos es_ES
dc.title Carbon-11 Radiolabelling of Organosulfur Compounds: 11C Synthesis of the Progesterone Receptor Agonist Tanaproget es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/chem.201501089
dc.relation.projectID info:eu-repo/grantAgreement/UKRI//EP%2FL025140%2F1/GB/De Novo Carbon-11 Chemistry: New and Explorative Radiolabelling Strategies for PET/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Royal Society//RG110449/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.description.bibliographicCitation Haywood, T.; Kealey, S.; Sánchez-Cabezas, S.; Hall, JJ.; Allott, L.; Smith, G.; Plisson, C.... (2015). Carbon-11 Radiolabelling of Organosulfur Compounds: 11C Synthesis of the Progesterone Receptor Agonist Tanaproget. Chemistry - A European Journal. 21(25):9034-9038. https://doi.org/10.1002/chem.201501089 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1002/chem.201501089 es_ES
dc.description.upvformatpinicio 9034 es_ES
dc.description.upvformatpfin 9038 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 21 es_ES
dc.description.issue 25 es_ES
dc.relation.senia 293500 es_ES
dc.identifier.pmid 25965348
dc.contributor.funder Engineering and Physical Sciences Research Council, Reino Unido
dc.contributor.funder UK Research and Innovation es_ES
dc.contributor.funder Royal Society, Reino Unido
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