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Organocatalytic Asymmetric Addition of Naphthols and Electron-Rich Phenols to Isatin-Derived Ketimines: Highly Enantioselective Construction of Tetrasubstituted Stereocenters

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Organocatalytic Asymmetric Addition of Naphthols and Electron-Rich Phenols to Isatin-Derived Ketimines: Highly Enantioselective Construction of Tetrasubstituted Stereocenters

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dc.contributor.author Montesinos Magraner, Marc es_ES
dc.contributor.author Vila, Carlos es_ES
dc.contributor.author Cantón, Rubén es_ES
dc.contributor.author Blay, Gonzalo es_ES
dc.contributor.author Fernández, Isabel es_ES
dc.contributor.author Muñoz Roca, María del Carmen es_ES
dc.contributor.author Pedro, José R. es_ES
dc.date.accessioned 2016-10-19T08:04:31Z
dc.date.available 2016-10-19T08:04:31Z
dc.date.issued 2015
dc.identifier.issn 1433-7851
dc.identifier.uri http://hdl.handle.net/10251/72285
dc.description.abstract A quinine-derived thiourea organocatalyst promoted the highly enantioselective addition of naphthols and activated phenols to ketimines derived from isatins. The reaction afforded chiral 3-amino-2-oxindoles with a quaternary stereocenter in high yields (up to 99%) with excellent enantioselectivity (up to 99% ee). To the best of our knowledge, this transformation is the first highly enantioselective addition of naphthols to ketimines es_ES
dc.description.sponsorship Financial support from the MINECO (Gobierno de Espana; CTQ2013-47494-P) and from Generalitat Valenciana (ISIC2012/001) is gratefully acknowledged. M.M.-M. thanks the Universitat de Valencia for a predoctoral grant. C.V. thanks MINECO for a JdC contract. en_EN
dc.language Inglés es_ES
dc.publisher Wiley es_ES
dc.relation info:eu-repo/grantAgreement/MINECO//CTQ2013-47494-P/ES/NUEVOS RETOS EN EL DESARROLLO DE PROCESOS ENANTIOSELECTIVOS DE FORMACION DE ENLACES C-C MEDIANTE CATALISIS DUAL COOPERATIVA./ es_ES
dc.relation Generalitat Valenciana ISIC2012/001 es_ES
dc.relation Universitat de Valencia es_ES
dc.relation MINECO es_ES
dc.relation.ispartof Angewandte Chemie International Edition es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Asymmetric synthesis es_ES
dc.subject Friedel-Crafts reactions es_ES
dc.subject Isatin-derived ketimines es_ES
dc.subject Naphthols es_ES
dc.subject Organocatalysis es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Organocatalytic Asymmetric Addition of Naphthols and Electron-Rich Phenols to Isatin-Derived Ketimines: Highly Enantioselective Construction of Tetrasubstituted Stereocenters es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/anie.201501273
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny es_ES
dc.description.bibliographicCitation Montesinos Magraner, M.; Vila, C.; Cantón, R.; Blay, G.; Fernández, I.; Muñoz Roca, MDC.; Pedro, JR. (2015). Organocatalytic Asymmetric Addition of Naphthols and Electron-Rich Phenols to Isatin-Derived Ketimines: Highly Enantioselective Construction of Tetrasubstituted Stereocenters. Angewandte Chemie International Edition. 54(21):6320-6324. https://doi.org/10.1002/anie.201501273 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1002/anie.201501273 es_ES
dc.description.upvformatpinicio 6320 es_ES
dc.description.upvformatpfin 6324 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 54 es_ES
dc.description.issue 21 es_ES
dc.relation.senia 293071 es_ES
dc.identifier.eissn 1521-3773
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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