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Correlating single nucleotide polymorphisms in the myostatin gene with performance traits in rabbit

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Correlating single nucleotide polymorphisms in the myostatin gene with performance traits in rabbit

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dc.contributor.author Abdel-Kafy, E.M. es_ES
dc.contributor.author Darwish, S.F. es_ES
dc.contributor.author ElKhishin, D. es_ES
dc.date.accessioned 2016-10-21T09:28:25Z
dc.date.available 2016-10-21T09:28:25Z
dc.date.issued 2016-09-28
dc.identifier.issn 1257-5011
dc.identifier.uri http://hdl.handle.net/10251/72558
dc.description.abstract [EN] The Myostatin (MSTN), or Growth and Differentiation Factor 8 (GDF8), gene has been implicated in the double muscling phenomenon, in which a series of mutations render the gene inactive and unable to properly regulate muscle fibre deposition. Single nucleotide polymorphisms (SNPs) in the MSTN gene have been correlated to production traits, making it a candidate target gene to enhance livestock and fowl productivity. This study aimed to assess any association of three SNPs in the rabbit MSTN gene (c.713T>A in exon 2, c.747+34C>T in intron 2, and c.*194A>G in 3’-untranslated region) and their combinations, with carcass, production and reproductive traits. The investigated traits included individual body weight, daily body weight gain, carcass traits and reproductive traits. The 3 SNPs were screened using PCR-restriction fragment length polymorphism (RFLP)-based analysis and the effects of the different SNP genotypes and their combinations were estimated in a rabbit population. Additionally, additive and dominance effects were estimated for significant traits. The results found no significant association between the c.713 T>A SNP and all the examined traits. Allele T at the c.747+34C>T SNP was only significantly associated (P<0.05) with increased body weight at 12 wk of age. However, for the SNP residing in the 3’ untranslated region (c.*194A>G), allele G was significantly associated (P<0.05) with increased body weight and high growth rate. Genotype GG at the c.*194A>G SNP also had positive effects on most carcass traits. The estimated additive genetic effect for the c.*194A>G SNP was significant (P<0.05) with most body weight, daily gain and carcass traits. No significant association was obtained between any MSTN SNPs and reproductive traits. In the combinations analysis, regardless of the genotypes of SNPs at c.713T>A and c.747+34C>T, GG at the c.*194A>G SNP correlated with highest values in body weight and daily weight gain. In conclusion, the ‘G’ allele at the c.*194A>G SNP had positive effects on growth and carcass traits and so could be used as a favourable allele in planning rabbit selection. Further population-wide studies are necessary to test the association of the c.*194A>G SNP with carcass traits. We also recommend evaluation of the potential effects of the c.*194A>G SNP on MSTN gene expression. es_ES
dc.language Inglés es_ES
dc.publisher Universitat Politècnica de València
dc.relation.ispartof World Rabbit Science
dc.rights Reserva de todos los derechos es_ES
dc.subject Rabbits es_ES
dc.subject Myostatin es_ES
dc.subject SNPs es_ES
dc.subject Genotype es_ES
dc.subject Growth es_ES
dc.title Correlating single nucleotide polymorphisms in the myostatin gene with performance traits in rabbit es_ES
dc.type Artículo es_ES
dc.date.updated 2016-09-30T12:40:17Z
dc.identifier.doi 10.4995/wrs.2016.4026
dc.rights.accessRights Abierto es_ES
dc.description.bibliographicCitation Abdel-Kafy, E.; Darwish, S.; Elkhishin, D. (2016). Correlating single nucleotide polymorphisms in the myostatin gene with performance traits in rabbit. World Rabbit Science. 24(3):213-221. doi:10.4995/wrs.2016.4026. es_ES
dc.relation.publisherversion https://doi.org/10.4995/wrs.2016.4026 es_ES
dc.description.upvformatpinicio 213 es_ES
dc.description.upvformatpfin 221 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 24
dc.description.issue 3
dc.identifier.eissn 1989-8886


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