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Sub-micrometric reflectometry for localized label-free biosensing

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Sub-micrometric reflectometry for localized label-free biosensing

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dc.contributor.author Casquel, R. es_ES
dc.contributor.author Soler, J. A. es_ES
dc.contributor.author Holgado, M. es_ES
dc.contributor.author Lopez, A. es_ES
dc.contributor.author Lavin, A. es_ES
dc.contributor.author de Vicente, J. es_ES
dc.contributor.author Sanza, F. J. es_ES
dc.contributor.author Laguna, M. F. es_ES
dc.contributor.author Holgado Bolaños, Miguel es_ES
dc.contributor.author Bañuls Polo, María-José es_ES
dc.contributor.author Puchades, Rosa es_ES
dc.date.accessioned 2016-10-24T13:02:49Z
dc.date.available 2016-10-24T13:02:49Z
dc.date.issued 2015-05-18
dc.identifier.issn 1094-4087
dc.identifier.uri http://hdl.handle.net/10251/72676
dc.description.abstract In this work we present an optical technique for characterizing sub-micrometric areas based on reflectivity of the light as a function of angle of incidence for the two pure polarizations s and p, covering a range of angles of incidence from -71.80 degrees to 71.80 degrees with a resolution of 0.1 degrees. Circular areas with a diameter in the order of 600 nm can be characterized, and the spectra for the two polarizations can be obtained with a single measurement. For biosensing purposes, we have fabricated several Bio Photonic Sensing Cells (BICELLs) consisting of interferometers of 1240 nm of SU-8 polymer over silicon. An indirect immunoassay is performed over these BICELLs and compared experimentally with FT-VIS-NIR spectrometry and theoretical calculations. The Limit of Detection (LoD) achieved is comparable with standard high resolution spectrometry, but with the capability of analyzing sub-micrometric domains for immunoassays reactions onto a sensing surface. (C) 2015 Optical Society of America es_ES
dc.description.sponsorship This work has been partially funded under the projects under the projects PLATON (Ref: TEC2012-31145) and INNBIOD (Ref: IPT-2011-1429-01000) from the Ministerio de Economia y Competitividad (MINECO) of Spain. We acknowledge Nightingale-EOS and Stephen Morris for his contribution to the development of this optical tool. en_EN
dc.language Inglés es_ES
dc.publisher Optical Society of America es_ES
dc.relation.ispartof Optics Express es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Optical sensing and sensors es_ES
dc.subject Thin films es_ES
dc.subject Optical properties es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.title Sub-micrometric reflectometry for localized label-free biosensing es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1364/OE.23.012544
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//TEC2012-31145/ES/BIOCHIP KITS BASADOS EN CELDAS BIOFOTONICAS Y PLATAFORMAS AVANZADAS DE INTERROGACION OPTICA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//IPT-2011-1429-010000/ES/INNOVACIÓN Y DESARROLLO DE SISTEMAS PORTÁTILES DE DETECCIÓN BIOLÓGICA ÓPTICA DE ALTA EFICIENCIA - INNBIOD/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario de Tecnología Nanofotónica - Institut Universitari de Tecnologia Nanofotònica es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Casquel, R.; Soler, JA.; Holgado, M.; Lopez, A.; Lavin, A.; De Vicente, J.; Sanza, FJ.... (2015). Sub-micrometric reflectometry for localized label-free biosensing. Optics Express. 23(10):12544-12554. doi:10.1364/OE.23.012544 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://dx.doi.org/10.1364/OE.23.012544 es_ES
dc.description.upvformatpinicio 12544 es_ES
dc.description.upvformatpfin 12554 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 23 es_ES
dc.description.issue 10 es_ES
dc.relation.senia 293502 es_ES
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