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Implantation of a polycaprolactone scaffold with subchondral bone anchoring ameliorates nodules formation and other tissue alterations

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Implantation of a polycaprolactone scaffold with subchondral bone anchoring ameliorates nodules formation and other tissue alterations

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dc.contributor.author Vikingsson, Line Karina Alva es_ES
dc.contributor.author Sancho-Tello Valls, Maria es_ES
dc.contributor.author Ruiz Sauri, Amparo es_ES
dc.contributor.author Martínez Díaz, Santos es_ES
dc.contributor.author Gómez-Tejedor, José Antonio es_ES
dc.contributor.author Gallego-Ferrer, Gloria es_ES
dc.contributor.author Carda, Carmen es_ES
dc.contributor.author Monllau Garcia, Joan Carles es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.date.accessioned 2016-12-01T12:29:40Z
dc.date.available 2016-12-01T12:29:40Z
dc.date.issued 2015
dc.identifier.issn 0391-3988
dc.identifier.uri http://hdl.handle.net/10251/74862
dc.description.abstract Purpose: Articular cartilage has limited repair capacity. Two different implant devices for articular cartilage regeneration were tested in vivo in a sheep model to evaluate the effect of subchondral bone anchoring for tissue repair. Methods: The implants were placed with press-fit technique in a cartilage defect after microfracture surgery in the femoral condyle of the knee joint of the sheep and histologic and mechanical evaluation was done 4.5 months later. The first group consisted of a biodegradable polycaprolactone (PCL) scaffold with double porosity. The second test group consisted of a PCL scaffold attached to a poly(L-lactic acid) (PLLA) pin anchored to the subchondral bone. Results: For both groups most of the defects (75%) showed an articular surface that was completely or almost completely repaired with a neotissue. Nevertheless, the surface had a rougher appearance than controls and the repair tissue was immature. In the trials with solely scaffold implantation, severe subchondral bone alterations were seen with many large nodular formations. These alterations were ameliorated when implanting the scaffold with a subchondral bone anchoring pin. Discussions: The results show that tissue repair is improved by implanting a PCL scaffold compared to solely microfracture surgery, and most importantly, that subchondral bone alterations, normally seen after microfracture surgery, were partially prevented when implanting the PCL scaffold with a fixation system to the subchondral bone. es_ES
dc.description.sponsorship This work was funded by the Spanish Ministry of Economy and Competitiveness (MINECO) through the MAT2013-46467-C4-R project (including FEDER financial support). CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program. CIBER actions are financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. en_EN
dc.language Inglés es_ES
dc.publisher Wichtig es_ES
dc.relation.ispartof International Journal of Artificial Organs es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Biomaterials es_ES
dc.subject Cartilage engineering es_ES
dc.subject Tissue engineering es_ES
dc.subject Polycaprolactone es_ES
dc.subject Subchondral bone alterations es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Implantation of a polycaprolactone scaffold with subchondral bone anchoring ameliorates nodules formation and other tissue alterations es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.5301/ijao.5000457
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2013-46467-C4-4-R/ES/ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2013-46467-C4-1-R/ES/ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVA/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Vikingsson, LKA.; Sancho-Tello Valls, M.; Ruiz Sauri, A.; Martínez Díaz, S.; Gómez-Tejedor, JA.; Gallego-Ferrer, G.; Carda, C.... (2015). Implantation of a polycaprolactone scaffold with subchondral bone anchoring ameliorates nodules formation and other tissue alterations. International Journal of Artificial Organs. 38(12):659-666. https://doi.org/10.5301/ijao.5000457 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.5301/ijao.5000457 es_ES
dc.description.upvformatpinicio 659 es_ES
dc.description.upvformatpfin 666 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 38 es_ES
dc.description.issue 12 es_ES
dc.relation.senia 306045 es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina es_ES
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