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Organocatalytic Enantioselective Synthesis of Pyrazoles Bearing a Quaternary Stereocenter

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Organocatalytic Enantioselective Synthesis of Pyrazoles Bearing a Quaternary Stereocenter

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dc.contributor.author Vila, Carlos es_ES
dc.contributor.author Amr, Fares Ibrahim es_ES
dc.contributor.author Blay, Gonzalo es_ES
dc.contributor.author Muñoz Roca, María del Carmen es_ES
dc.contributor.author Pedro, José R. es_ES
dc.date.accessioned 2016-12-09T15:11:17Z
dc.date.available 2016-12-09T15:11:17Z
dc.date.issued 2016-05-20
dc.identifier.issn 1861-4728
dc.identifier.uri http://hdl.handle.net/10251/75067
dc.description.abstract An efficient one-pot asymmetric synthesis of pyrazoles bearing a chiral quaternary stereocenter has been developed. Quinine-derived thiourea catalyzed the enantioselective addition of pyrazolones to isatin-derived ketimines, providing the corresponding acetylated pyrazoles after in situ treatment with Ac2O/Et3N. The corresponding pyrazoles were afforded in high yields and excellent enantioselectivities. es_ES
dc.description.sponsorship Financial support from the MINECO (Gobierno de Espana; CTQ2013-47494-P) and from Generalitat Valenciana (ISIC2012/001) is gratefully acknowledged. C.V. thanks MINECO for a JdC contract. Access to NMR, MS and X-ray facilities from the Servei central de suport a la investigacio experimental (SCSIE)-UV is also acknowledged. en_EN
dc.language Inglés es_ES
dc.publisher Wiley es_ES
dc.relation.ispartof Chemistry - An Asian Journal es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Asymmetric catalysis es_ES
dc.subject Isatin-derived ketimines es_ES
dc.subject Organocatalysis es_ES
dc.subject Pyrazoles es_ES
dc.subject Quaternary stereocenters es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Organocatalytic Enantioselective Synthesis of Pyrazoles Bearing a Quaternary Stereocenter es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/asia.201600325
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CTQ2013-47494-P/ES/NUEVOS RETOS EN EL DESARROLLO DE PROCESOS ENANTIOSELECTIVOS DE FORMACION DE ENLACES C-C MEDIANTE CATALISIS DUAL COOPERATIVA./ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//ISIC2012%2F 001/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny es_ES
dc.description.bibliographicCitation Vila, C.; Amr, FI.; Blay, G.; Muñoz Roca, MDC.; Pedro, JR. (2016). Organocatalytic Enantioselective Synthesis of Pyrazoles Bearing a Quaternary Stereocenter. Chemistry - An Asian Journal. 11(10):1532-1536. https://doi.org/10.1002/asia.201600325 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1002/asia.201600325 es_ES
dc.description.upvformatpinicio 1532 es_ES
dc.description.upvformatpfin 1536 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 11 es_ES
dc.description.issue 10 es_ES
dc.relation.senia 316157 es_ES
dc.identifier.eissn 1861-471X
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Generalitat Valenciana es_ES
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