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Complement activation product C4d in oral and oropharyngeal squamous cell carcinoma

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Complement activation product C4d in oral and oropharyngeal squamous cell carcinoma

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dc.contributor.author Ajona, D. es_ES
dc.contributor.author Pajares, M. J. es_ES
dc.contributor.author Chiara, M. D. es_ES
dc.contributor.author Rodrigo, J. P. es_ES
dc.contributor.author Jantus Lewintre, Eloisa es_ES
dc.contributor.author Camps, C. es_ES
dc.contributor.author Suarez, C. es_ES
dc.contributor.author Bagan, J. V. es_ES
dc.contributor.author Montuenga, L. M. es_ES
dc.contributor.author Pio, R. es_ES
dc.date.accessioned 2017-01-24T12:32:53Z
dc.date.available 2017-01-24T12:32:53Z
dc.date.issued 2015-10
dc.identifier.issn 1354-523X
dc.identifier.uri http://hdl.handle.net/10251/77266
dc.description.abstract OBJECTIVE: Complement C4d-containing fragments have been proposed as diagnostic markers for lung cancer. The purpose of this study was to evaluate the presence of C4d in oropharyngeal (OPSCC) and oral (OSCC) squamous cell carcinomas. SUBJECTS AND METHODS: C4d staining was analyzed by immunohistochemistry in 244 OPSCC surgical specimens. C4d levels were quantified by ELISA in resting saliva samples from 48 patients with oral leukoplakia and 62 with OSCC. Plasma samples from 21 patients with leukoplakia and 30 with oral carcinoma were also studied. RESULTS: C4d staining in OPSCC specimens was associated with nodal invasion (P = 0.001), histopathologic grade (P = 0.014), disease stage (P = 0.040), and focal-adhesion kinase expression (P < 0.001). No association was found between C4d and prognosis. Saliva C4d levels were higher in patients with oral cancer than in subjects with leukoplakia (0.07 +/- 0.07 vs 0.04 +/- 0.03 mu g ml(-1), P = 0.003). The area under the ROC curve was 0.63 (95%CI: 0.55-0.71). Salivary C4d levels in stage IV patients were higher than in patients with earlier stages (P = 0.028) and correlated with tumor size (P = 0.045). Plasma C4d levels also correlated with salivary C4d levels (P = 0.041), but differences between patients with oral cancer and subjects with leukoplakia were not significant (1.26 +/- 0.59 vs 1.09 +/- 0.39 mu g ml(-1), P = 0.232). CONCLUSION: C4d-containing fragments are detected in oral primary tumors and are increased in saliva from patients with OSCC. es_ES
dc.description.sponsorship We thank Amaya Lavin for technical assistance. This work was supported by Foundation for Applied Medical Research (FIMA), Red Tematica de Investigacion Cooperativa en Cancer (RD12/0036/0015, RD12/0036/0025, and RD12/0036/0040), and Fondo de Investigacion Sanitaria-Fondo Europeo de Desarrollo Regional (FEDER, PI11/00618, PI13/00806, PI11/00929, and PI14/01686). en_EN
dc.language Inglés es_ES
dc.publisher Wiley es_ES
dc.relation.ispartof Oral Diseases es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Head and neck cancer es_ES
dc.subject Squamous cell carcinoma es_ES
dc.subject Oral cancer es_ES
dc.subject Biomarker es_ES
dc.subject Diagnosis es_ES
dc.subject Complement system es_ES
dc.subject C4d es_ES
dc.subject Saliva es_ES
dc.subject.classification MICROBIOLOGIA es_ES
dc.title Complement activation product C4d in oral and oropharyngeal squamous cell carcinoma es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1111/odi.12363
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//RD12%2F0036%2F0040/ES/Cáncer/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//PI11%2F00929/ES/Alteraciones genético-moleculares implicadas en el inicio y progresión de los tumores de cabeza y cuello y sus implicaciones clínicas/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//PI11%2F00618/ES/Papel del sistema del complemento en la progresión tumoral e identificación de marcadores moleculares relacionados su activación/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//RD12%2F0036%2F0015/ES/Cáncer/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//PI13%2F00806/ES/Herramientas moleculares para el análisis pronóstico y la identificación de nuevas dianas terapéuticas en carcinoma no microcítico de pulmón/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//RD12%2F0036%2F0025/ES/Cáncer/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//PI14%2F01686/ES/Identificación y validación de marcadores diagnósticos y dianas terapéuticas en cáncer de pulmón relacionados con la activación del sistema del complemento/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural es_ES
dc.description.bibliographicCitation Ajona, D.; Pajares, MJ.; Chiara, MD.; Rodrigo, JP.; Jantus Lewintre, E.; Camps, C.; Suarez, C.... (2015). Complement activation product C4d in oral and oropharyngeal squamous cell carcinoma. Oral Diseases. 21(7):899-904. doi:10.1111/odi.12363 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://dx.doi.org/10.1111/odi.12363 es_ES
dc.description.upvformatpinicio 899 es_ES
dc.description.upvformatpfin 904 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 21 es_ES
dc.description.issue 7 es_ES
dc.relation.senia 301836 es_ES
dc.identifier.eissn 1601-0825
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Fundación para la Investigación Médica Aplicada es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
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