Ajona, D., Pajares, M. J., Corrales, L., Perez-Gracia, J. L., Agorreta, J., Lozano, M. D., … Pio, R. (2013). Investigation of Complement Activation Product C4d as a Diagnostic and Prognostic Biomarker for Lung Cancer. JNCI: Journal of the National Cancer Institute, 105(18), 1385-1393. doi:10.1093/jnci/djt205
Ajona, D., Razquin, C., Pastor, M. D., Pajares, M. J., Garcia, J., Cardenal, F., … Pio, R. (2015). Elevated Levels of the Complement Activation Product C4d in Bronchial Fluids for the Diagnosis of Lung Cancer. PLOS ONE, 10(3), e0119878. doi:10.1371/journal.pone.0119878
Arantes, L. M. R. B., de Carvalho, A. C., Melendez, M. E., Carvalho, A. L., & Goloni-Bertollo, E. M. (2014). Methylation as a biomarker for head and neck cancer. Oral Oncology, 50(6), 587-592. doi:10.1016/j.oraloncology.2014.02.015
[+]
Ajona, D., Pajares, M. J., Corrales, L., Perez-Gracia, J. L., Agorreta, J., Lozano, M. D., … Pio, R. (2013). Investigation of Complement Activation Product C4d as a Diagnostic and Prognostic Biomarker for Lung Cancer. JNCI: Journal of the National Cancer Institute, 105(18), 1385-1393. doi:10.1093/jnci/djt205
Ajona, D., Razquin, C., Pastor, M. D., Pajares, M. J., Garcia, J., Cardenal, F., … Pio, R. (2015). Elevated Levels of the Complement Activation Product C4d in Bronchial Fluids for the Diagnosis of Lung Cancer. PLOS ONE, 10(3), e0119878. doi:10.1371/journal.pone.0119878
Arantes, L. M. R. B., de Carvalho, A. C., Melendez, M. E., Carvalho, A. L., & Goloni-Bertollo, E. M. (2014). Methylation as a biomarker for head and neck cancer. Oral Oncology, 50(6), 587-592. doi:10.1016/j.oraloncology.2014.02.015
Bagan, J., Sarrion, G., & Jimenez, Y. (2010). Oral cancer: Clinical features. Oral Oncology, 46(6), 414-417. doi:10.1016/j.oraloncology.2010.03.009
Bell, R. B., Kademani, D., Homer, L., Dierks, E. J., & Potter, B. E. (2007). Tongue Cancer: Is There a Difference in Survival Compared With Other Subsites in the Oral Cavity? Journal of Oral and Maxillofacial Surgery, 65(2), 229-236. doi:10.1016/j.joms.2005.11.094
Bjørge, L., Hakulinen, J., Vintermyr, O. K., Jarva, H., Jensen, T. S., Iversen, O. E., & Meri, S. (2005). Ascitic complement system in ovarian cancer. British Journal of Cancer, 92(5), 895-905. doi:10.1038/sj.bjc.6602334
Blom, A. M., Österborg, A., Mollnes, T. E., & Okroj, M. (2015). Antibodies reactive to cleaved sites in complement proteins enable highly specific measurement of soluble markers of complement activation. Molecular Immunology, 66(2), 164-170. doi:10.1016/j.molimm.2015.02.029
Brailo, V., Vucicevic-Boras, V., Lukac, J., Biocina-Lukenda, D., Alajbeg-Zilic, I., Milenovic, A., & Balija, M. (2012). Salivary and serum interleukin 1 beta, interleukin 6 and tumor necrosis factor alpha in patients with leukoplakia and oral cancer. Medicina Oral Patología Oral y Cirugia Bucal, e10-e15. doi:10.4317/medoral.17323
Canel, M. (2006). Overexpression of Focal Adhesion Kinase in Head and Neck Squamous Cell Carcinoma Is Independent of fak Gene Copy Number. Clinical Cancer Research, 12(11), 3272-3279. doi:10.1158/1078-0432.ccr-05-1583
Canel, M., Secades, P., Garzón-Arango, M., Allonca, E., Suarez, C., Serrels, A., … Chiara, M.-D. (2008). Involvement of focal adhesion kinase in cellular invasion of head and neck squamous cell carcinomas via regulation of MMP-2 expression. British Journal of Cancer, 98(7), 1274-1284. doi:10.1038/sj.bjc.6604286
Cheng, Y.-S., Rees, T., & Wright, J. (2014). A review of research on salivary biomarkers for oral cancer detection. Clinical and Translational Medicine, 3(1), 3. doi:10.1186/2001-1326-3-3
Corrales, L., Ajona, D., Rafail, S., Lasarte, J. J., Riezu-Boj, J. I., Lambris, J. D., … Pio, R. (2012). Anaphylatoxin C5a Creates a Favorable Microenvironment for Lung Cancer Progression. The Journal of Immunology, 189(9), 4674-4683. doi:10.4049/jimmunol.1201654
Franzmann, E. J., Reategui, E. P., Pedroso, F., Pernas, F. G., Karakullukcu, B. M., Carraway, K. L., … Goodwin, W. J. (2007). Soluble CD44 Is a Potential Marker for the Early Detection of Head and Neck Cancer. Cancer Epidemiology Biomarkers & Prevention, 16(7), 1348-1355. doi:10.1158/1055-9965.epi-06-0011
Hajishengallis, G. (2010). Complement and periodontitis. Biochemical Pharmacology, 80(12), 1992-2001. doi:10.1016/j.bcp.2010.06.017
Hoadley, K. A., Yau, C., Wolf, D. M., Cherniack, A. D., Tamborero, D., Ng, S., … Stuart, J. M. (2014). Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin. Cell, 158(4), 929-944. doi:10.1016/j.cell.2014.06.049
Hu, S., Arellano, M., Boontheung, P., Wang, J., Zhou, H., Jiang, J., … Wong, D. T. (2008). Salivary Proteomics for Oral Cancer Biomarker Discovery. Clinical Cancer Research, 14(19), 6246-6252. doi:10.1158/1078-0432.ccr-07-5037
De Jong, E. P., Xie, H., Onsongo, G., Stone, M. D., Chen, X.-B., Kooren, J. A., … Griffin, T. J. (2010). Quantitative Proteomics Reveals Myosin and Actin as Promising Saliva Biomarkers for Distinguishing Pre-Malignant and Malignant Oral Lesions. PLoS ONE, 5(6), e11148. doi:10.1371/journal.pone.0011148
Kesselring, R., Thiel, A., Pries, R., Fichtner-Feigl, S., Brunner, S., Seidel, P., … Wollenberg, B. (2014). The complement receptors CD46, CD55 and CD59 are regulated by the tumour microenvironment of head and neck cancer to facilitate escape of complement attack. European Journal of Cancer, 50(12), 2152-2161. doi:10.1016/j.ejca.2014.05.005
Lingen, M. W. (2010). Screening for Oral Premalignancy and Cancer: What Platform and Which Biomarkers? Cancer Prevention Research, 3(9), 1056-1059. doi:10.1158/1940-6207.capr-10-0173
Liu, C.-J., Lin, S.-C., Yang, C.-C., Cheng, H.-W., & Chang, K.-W. (2011). Exploiting salivary miR-31 as a clinical biomarker of oral squamous cell carcinoma. Head & Neck, 34(2), 219-224. doi:10.1002/hed.21713
Marimuthu, A., Chavan, S., Sathe, G., Sahasrabuddhe, N. A., Srikanth, S. M., Renuse, S., … Chatterjee, A. (2013). Identification of head and neck squamous cell carcinoma biomarker candidates through proteomic analysis of cancer cell secretome. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1834(11), 2308-2316. doi:10.1016/j.bbapap.2013.04.029
Markiewski, M. M., DeAngelis, R. A., Benencia, F., Ricklin-Lichtsteiner, S. K., Koutoulaki, A., Gerard, C., … Lambris, J. D. (2008). Modulation of the antitumor immune response by complement. Nature Immunology, 9(11), 1225-1235. doi:10.1038/ni.1655
McCormack, S. J., Brazinski, S. E., Jr, J. L. M., Werness, B. A., & Goldstein, D. J. (1997). Activation of the focal adhesion kinase signal transduction pathway in cervical carcinoma cell lines and human genital epithelial cells immortalized with human papillomavirus type 18. Oncogene, 15(3), 265-274. doi:10.1038/sj.onc.1201186
Menéndez, S. T., Rodrigo, J. P., Álvarez-Teijeiro, S., Villaronga, M. Á., Allonca, E., Vallina, A., … García-Pedrero, J. M. (2012). Role of HERG1 potassium channel in both malignant transformation and disease progression in head and neck carcinomas. Modern Pathology, 25(8), 1069-1078. doi:10.1038/modpathol.2012.63
Nitta, H., Wada, Y., Kawano, Y., Murakami, Y., Irie, A., Taniguchi, K., … Imamura, T. (2013). Enhancement of Human Cancer Cell Motility and Invasiveness by Anaphylatoxin C5a via Aberrantly Expressed C5a Receptor (CD88). Clinical Cancer Research, 19(8), 2004-2013. doi:10.1158/1078-0432.ccr-12-1204
NITTA, H., MURAKAMI, Y., WADA, Y., ETO, M., BABA, H., & IMAMURA, T. (2014). Cancer cells release anaphylatoxin C5a from C5 by serine protease to enhance invasiveness. Oncology Reports, 32(4), 1715-1719. doi:10.3892/or.2014.3341
Nunez-Cruz, S., Gimotty, P. A., Guerra, M. W., Connolly, D. C., Wu, Y.-Q., DeAngelis, R. A., … Scholler, N. (2012). Genetic and Pharmacologic Inhibition of Complement Impairs Endothelial Cell Function and Ablates Ovarian Cancer Neovascularization. Neoplasia, 14(11), 994-IN1. doi:10.1593/neo.121262
Pajares, M. J., Agorreta, J., Larrayoz, M., Vesin, A., Ezponda, T., Zudaire, I., … Montuenga, L. M. (2012). Expression of Tumor-Derived Vascular Endothelial Growth Factor and Its Receptors Is Associated With Outcome in Early Squamous Cell Carcinoma of the Lung. Journal of Clinical Oncology, 30(10), 1129-1136. doi:10.1200/jco.2011.37.4231
Pardoll, D. (2003). DOES THEIMMUNESYSTEMSEETUMORS ASFOREIGN ORSELF? Annual Review of Immunology, 21(1), 807-839. doi:10.1146/annurev.immunol.21.120601.141135
Park, N. J., Zhou, H., Elashoff, D., Henson, B. S., Kastratovic, D. A., Abemayor, E., & Wong, D. T. (2009). Salivary microRNA: Discovery, Characterization, and Clinical Utility for Oral Cancer Detection. Clinical Cancer Research, 15(17), 5473-5477. doi:10.1158/1078-0432.ccr-09-0736
Pio, R., Corrales, L., & Lambris, J. D. (2013). The Role of Complement in Tumor Growth. Tumor Microenvironment and Cellular Stress, 229-262. doi:10.1007/978-1-4614-5915-6_11
Polanska, H., Raudenska, M., Gumulec, J., Sztalmachova, M., Adam, V., Kizek, R., & Masarik, M. (2014). Clinical significance of head and neck squamous cell cancer biomarkers. Oral Oncology, 50(3), 168-177. doi:10.1016/j.oraloncology.2013.12.008
Prasad, G., & McCullough, M. (2013). Chemokines and Cytokines as Salivary Biomarkers for the Early Diagnosis of Oral Cancer. International Journal of Dentistry, 2013, 1-7. doi:10.1155/2013/813756
Ravindranath, N. M. H., & Shuler, C. (2006). Expression of complement restriction factors (CD46, CD55 & CD59) in head and neck squamous cell carcinomas. Journal of Oral Pathology and Medicine, 35(9), 560-567. doi:10.1111/j.1600-0714.2006.00466.x
Rhodus, N. L., Ho, V., Miller, C. S., Myers, S., & Ondrey, F. (2005). NF-κB dependent cytokine levels in saliva of patients with oral preneoplastic lesions and oral squamous cell carcinoma. Cancer Detection and Prevention, 29(1), 42-45. doi:10.1016/j.cdp.2004.10.003
Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010). Complement: a key system for immune surveillance and homeostasis. Nature Immunology, 11(9), 785-797. doi:10.1038/ni.1923
Rodrigo, J. P., Heideman, D. A. M., García-Pedrero, J. M., Fresno, M. F., Brakenhoff, R. H., Díaz Molina, J. P., … Hermsen, M. A. (2013). Time trends in the prevalence of HPV in oropharyngeal squamous cell carcinomas in northern Spain (1990-2009). International Journal of Cancer, 134(2), 487-492. doi:10.1002/ijc.28355
Sainger, R. N. S., Shah, M. H., Desai, A. A., Shukla, S. N., Shah, P. M., Telang, S. D., & Patel, P. S. (2006). Clinical Significance of Serum p53 Antibodies in Oral Cancer. Tumori Journal, 92(2), 134-139. doi:10.1177/030089160609200209
Vadrevu, S. K., Chintala, N. K., Sharma, S. K., Sharma, P., Cleveland, C., Riediger, L., … Markiewski, M. M. (2014). Complement C5a Receptor Facilitates Cancer Metastasis by Altering T-Cell Responses in the Metastatic Niche. Cancer Research, 74(13), 3454-3465. doi:10.1158/0008-5472.can-14-0157
Vaezi, A. E., Bepler, G., Bhagwat, N. R., Malysa, A., Rubatt, J. M., Chen, W., … Niedernhofer, L. J. (2014). Choline phosphate cytidylyltransferase-α is a novel antigen detected by the anti-ERCC1 antibody 8F1 with biomarker value in patients with lung and head and neck squamous cell carcinomas. Cancer, 120(12), 1898-1907. doi:10.1002/cncr.28643
Van der Waal, I. (2010). Potentially malignant disorders of the oral and oropharyngeal mucosa; present concepts of management. Oral Oncology, 46(6), 423-425. doi:10.1016/j.oraloncology.2010.02.016
Yang, Y., Chung, E. K., Zhou, B., Blanchong, C. A., Yu, C. Y., Füst, G., … Varga, L. (2003). Diversity in Intrinsic Strengths of the Human Complement System: Serum C4 Protein Concentrations Correlate with C4 Gene Size and Polygenic Variations, Hemolytic Activities, and Body Mass Index. The Journal of Immunology, 171(5), 2734-2745. doi:10.4049/jimmunol.171.5.2734
Ytting, H., Jensenius, J. C., Christensen, I. J., Thiel, S., & Nielsen, H. J. (2004). Increased activity of the mannan‐binding lectin complement activation pathway in patients with colorectal cancer. Scandinavian Journal of Gastroenterology, 39(7), 674-679. doi:10.1080/00365520410005603
Zimmermann, B. G., & Wong, D. T. (2008). Salivary mRNA targets for cancer diagnostics. Oral Oncology, 44(5), 425-429. doi:10.1016/j.oraloncology.2007.09.009
[-]