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Evolution of the Properties of a Poly(L-lactic acid) Scaffold with Double Porosity During In Vitro Degradation in a Phosphate-Buffered Saline Solution

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Evolution of the Properties of a Poly(L-lactic acid) Scaffold with Double Porosity During In Vitro Degradation in a Phosphate-Buffered Saline Solution

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dc.contributor.author Deplaine, Harmony es_ES
dc.contributor.author Acosta-Santamaría, Victor A. es_ES
dc.contributor.author Vidaurre Garayo, Ana Jesús es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.contributor.author Doblare Castellano, Manuel es_ES
dc.contributor.author Ochoa-Garrido, Ignacio es_ES
dc.contributor.author Gallego Ferrer, Gloria es_ES
dc.date.accessioned 2017-05-17T11:40:59Z
dc.date.available 2017-05-17T11:40:59Z
dc.date.issued 2014-10-15
dc.identifier.issn 0021-8995
dc.identifier.uri http://hdl.handle.net/10251/81280
dc.description.abstract [EN] A poly(L-lactic acid) scaffold prepared by a combination of freeze-extraction and porogen-leaching methods was submitted to static degradation in a phosphate-buffered saline solution at pH 7.4 and 37 C for up to 12 months. After 6 months of degradation, the scaffold maintained its integrity, although noticeable changes in its permeability and pore size were recorded. After 12 months, scanning electron microscopy pictures showed that most of the trabeculae were broken, and the sample disaggregated under minimum loading. Neither weight loss nor crystallinity changes in the first heating calorimetric scan were observed during the degradation experiment. However, after 12 months, a rise in the crystallinity from 13 to 38% and a drop in the glass-transition temperature from 58 to 54 C were measured in the second heating scan. The onset of thermal degradation moved from 300 to 210 C after 12 months. Although the elastic modulus suffered only a very slight reduction with degradation time, the aggregate modulus decreased 44% after 6 months. es_ES
dc.description.sponsorship The authors acknowledge the support of the Instituto de Salud Carlos III, Ministerio de Economıa y Competitividad, and the European Commission through FP7-ERANet EuroNanoMed 2011 PI11/03032 and FP7-PEOPLE-2012-IAPP (contract grant number PIAP-GA-2012–324386). The Biomedical Research Networking Center in Bioengineering, Biomaterials, and Nanomedicine is an initiative funded by the VI National R&D&i Plan 2008–2011, Iniciativa Ingenio 2010, and Consolider Program. Biomedical Research Networking Center actions are financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. The authors also thank the Tissue Characterization Platform of the Biomedical Research Networking Center in Bioengineering, Biomaterials, and Nanomedicine for its technical support. They also thank the Linguistic Assistance Services of the Language Centre, Universitat Politecnica de Valencia, for their help in revising this article.
dc.language Inglés es_ES
dc.publisher Wiley es_ES
dc.relation.ispartof Journal of Applied Polymer Science es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Biomedical applications es_ES
dc.subject Degradation es_ES
dc.subject Mechanical properties es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Evolution of the Properties of a Poly(L-lactic acid) Scaffold with Double Porosity During In Vitro Degradation in a Phosphate-Buffered Saline Solution es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/APP.40956
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/324386/EU/Network for Development of Soft Nanofibrous Construct for Cellular Therapy of Degenerative Skeletal Disorders/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ARC/Discovery Projects/DP110103032/AU/Nanoscale characterisation of the dynamics of artificial lipid membranes - model systems for drug binding studies/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny es_ES
dc.description.bibliographicCitation Deplaine, H.; Acosta-Santamaría, VA.; Vidaurre Garayo, AJ.; Gómez Ribelles, JL.; Doblare Castellano, M.; Ochoa-Garrido, I.; Gallego Ferrer, G. (2014). Evolution of the Properties of a Poly(L-lactic acid) Scaffold with Double Porosity During In Vitro Degradation in a Phosphate-Buffered Saline Solution. Journal of Applied Polymer Science. 131:40956-40966. https://doi.org/10.1002/APP.40956 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1002/app.40956 es_ES
dc.description.upvformatpinicio 40956 es_ES
dc.description.upvformatpfin 40966 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 131 es_ES
dc.relation.senia 278733 es_ES
dc.identifier.eissn 1097-4628
dc.contributor.funder European Commission
dc.contributor.funder Ministerio de Economía y Competitividad
dc.contributor.funder Instituto de Salud Carlos III
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