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Pathological changes and local defense reaction occurring in spontaneous hepatic coccidiosis in rabbits (Oryctolagus cuniculus).

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Pathological changes and local defense reaction occurring in spontaneous hepatic coccidiosis in rabbits (Oryctolagus cuniculus).

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dc.contributor.author Darzi, M.M.
dc.contributor.author Mir, M.S.
dc.contributor.author Kamil, S.A.
dc.contributor.author Nashiruddullah, N.
dc.contributor.author Munshi, Z.H.
dc.date.accessioned 2010-05-13T11:41:01Z
dc.date.available 2010-05-13T11:41:01Z
dc.date.issued 2007
dc.identifier.issn 1257-5011
dc.identifier.uri http://hdl.handle.net/10251/8212
dc.description.abstract [EN] Hepatic coccidiosis occurred in 56 rabbits belonging to different ages, sexes and breeds during the years from 2002 to 2005. Clinically, the severely affected rabbits showed decreased growth rate, anorexia, debilitation, listlessness, diarrhea, icterus and rough hair coat. Postmortem examinations revealed increased dirty dull straw colored peritoneal fluid. Hepatomegaly, with presence of discrete yellowish-white nodules of 1mm to 1 cm size on the surface and throughout the parenchyma, was seen. Smears from peritoneal fluid showed rafts of mesothelial cells. Impression smears from the liver nodules revealed presence of numerous developmental stages of Eimeria stiedae corresponding with the stage of the liver lesion. These were intermixed with sheats of hepatobiliary cells and inflammatory cells and the changes were reflective of the histological changes like biliary hyperplasia, cholangitis and vacuolar changes occurring in the liver. There was increase in the thickness of basement membrane with the advanced stage of the lesion. The basement membrane was up to 1-2 µm in thickness forming loop like structures over which resided hyperplastic biliary cells containing different stages of the parasite. Some thickened basement membranes were devoid of overlying cells which had desquamated and were present in the ductal lumens suggesting that the basement might have the local defensive role in warding of the coccidial infection. The basement membrane was positive for neutral mucopolysaccharides while as the inflammatory zones and biliary epithelia along with the gametogonic stages of the coccidium reacted positively to the increased acid mucopolysaccharides qualitatively. The results showed that the occurrence of hepatic coccidiosis in female rabbits coincided with the breeding and kindling periods. Direct wet mount smears from bile aid in diagnosis of the disease. Impression smears from the liver nodules might represent the histological changes in the liver. The basement membrane thickening might have a defensive role in warding off the coccidial infection. en_EN
dc.language Inglés en_EN
dc.publisher World Rabbit Science. ICTA. UPV en_EN
dc.relation.ispartof World Rabbit Science
dc.rights Reconocimiento - No comercial (by-nc) en_EN
dc.subject Local defense en_EN
dc.subject Pathology en_EN
dc.subject Eimeria stiedae en_EN
dc.subject Hepatic coccidiosis en_EN
dc.subject Rabbit en_EN
dc.title Pathological changes and local defense reaction occurring in spontaneous hepatic coccidiosis in rabbits (Oryctolagus cuniculus). en_EN
dc.type Artículo en_EN
dc.identifier.doi 10.4995/wrs.2007.608
dc.rights.accessRights Abierto es_ES
dc.description.bibliographicCitation Darzi, M.; Mir, M.; Kamil, S.; Nashiruddullah, N.; Munshi, Z. (2007). Pathological changes and local defense reaction occurring in spontaneous hepatic coccidiosis in rabbits (Oryctolagus cuniculus). World Rabbit Science. 15(1):23-28. doi:10.4995/wrs.2007.608 es_ES
dc.relation.publisherversion https://doi.org/10.4995/wrs.2007.608
dc.description.upvformatpinicio 23
dc.description.upvformatpfin 28
dc.description.volume 15
dc.description.issue 1
dc.identifier.eissn 1989-8886 es_ES


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