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dc.contributor.author | Deplaine, Harmony | es_ES |
dc.contributor.author | Lebourg, Myriam Madeleine | es_ES |
dc.contributor.author | Ripalda, P | es_ES |
dc.contributor.author | Vidaurre Garayo, Ana Jesús | es_ES |
dc.contributor.author | Sanz-Ramos, Patricia | es_ES |
dc.contributor.author | Mora, Gonzalo | es_ES |
dc.contributor.author | Prósper, Felipe | es_ES |
dc.contributor.author | Ochoa, I. | es_ES |
dc.contributor.author | Doblare Castellano, Manuel | es_ES |
dc.contributor.author | Gómez Ribelles, José Luís | es_ES |
dc.contributor.author | IZAL AZCARATE, IÑIGO | es_ES |
dc.contributor.author | Gallego-Ferrer, Gloria | es_ES |
dc.date.accessioned | 2017-07-10T08:12:55Z | |
dc.date.available | 2017-07-10T08:12:55Z | |
dc.date.issued | 2013-01 | |
dc.identifier.issn | 1552-4973 | |
dc.identifier.uri | http://hdl.handle.net/10251/84804 | |
dc.description.abstract | [EN] Polymer ceramic composites obtained as the result of a mineralization process hold great promise for the future of tissue engineering. Simulated body fluids (SBFs) are widely used for the mineralization of polymer scaffolds. In this work an exhaustive study with the aim of optimizing the mineralization process on a poly(L-lactic acid) (PLLA) macroporous scaffold has been performed. We observed that when an air plasma treatment is applied to the PLLA scaffold its hydroxyapatite nucleation ability is considerably improved. However, plasma treatment only allows apatite deposition on the surface of the scaffold but not in its interior. When a 5 wt % of synthetic hydroxyapatite (HAp) nanoparticles is mixed with PLLA a more abundant biomimetic hydroxyapatite layer grows inside the scaffold in SBF. The morphology, amount, and composition of the generated biomimetic hydroxyapatite layer on the pores surface have been analyzed. Large mineralization times are harmful to pure PLLA as it rapidly degrades and its elastic compression modulus significantly decreases. Degradation is retarded in the composite scaffolds because of the faster and extensive biomimetic apatite deposition and the role of HAp to control the pH. Mineralized scaffolds, covered by an apatite layer in SBF, were implanted in osteochondral lesions performed in the medial femoral condyle of healthy sheep. We observed that the presence of biomimetic hydroxyapatite on the pore s surface of the composite scaffold produces a better integration in the subchondral bone, in comparison to bare PLLA scaffolds. | es_ES |
dc.description.sponsorship | Contract grant sponsor: CIBER-BBN, VI National R&D&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, Instituto de Salud Carlos III with assistance from the European Regional Development Fund | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation.ispartof | Journal of Biomedical Materials Research Part B: Applied Biomaterials | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Bioactive material | es_ES |
dc.subject | Biomimetic | es_ES |
dc.subject | Osteogenesis | es_ES |
dc.subject | Composite/hard tissue | es_ES |
dc.subject | Scaffolds | es_ES |
dc.subject.classification | MAQUINAS Y MOTORES TERMICOS | es_ES |
dc.subject.classification | FISICA APLICADA | es_ES |
dc.title | Biomimetic hydroxyapatite coating on pore walls improves osteointegration of poly(L-lactic acid) scaffolds | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1002/jbm.b.32831 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//DPI2010-20399-C04-04/ES/DISEÑO, CONSTRUCCION Y VALIDACION DE UNA PLATAFORMA BIOMIMETICA PARA LA EVALUACION FUNCIONAL Y OPTIMIZACION DE CONSTRUCTOS DE INGENIERIA TISULAR PARA LA REPARACION DE CARTILAG/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//DPI2010-20399-C04-01/ES/DISEÑO, CONSTRUCCION Y VALIDACION DE UNA PLATAFORMA BIOMIMETICA PARA LA EVALUACION FUNCIONAL Y OPTIMIZACION DE CONSTRUCTOS DE INGENIERIA TISULAR DE CARTILAGO ARTICULAR/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//DPI2010-20399-C04-03/ES/DISEÑO Y FABRICACION DE UNA PLATAFORMA BIOMIMETICA TIPO SCAFFOLD%2FSOPORTE PARA LA REGENERACION DEL CARTILAGO ARTICULAR/ | es_ES |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny | es_ES |
dc.description.bibliographicCitation | Deplaine, H.; Lebourg, MM.; Ripalda, P.; Vidaurre Garayo, AJ.; Sanz-Ramos, P.; Mora, G.; Prósper, F.... (2013). Biomimetic hydroxyapatite coating on pore walls improves osteointegration of poly(L-lactic acid) scaffolds. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 101B(1):173-186. https://doi.org/10.1002/jbm.b.32831 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1002/jbm.b.32831 | es_ES |
dc.description.upvformatpinicio | 173 | es_ES |
dc.description.upvformatpfin | 186 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 101B | es_ES |
dc.description.issue | 1 | es_ES |
dc.relation.senia | 237392 | es_ES |
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