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Cell-free cartilage engineering approach using hyaluronic acid-polycaprolactone scaffolds: A study invivo

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Cell-free cartilage engineering approach using hyaluronic acid-polycaprolactone scaffolds: A study invivo

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dc.contributor.author Lebourg, Myriam Madeleine es_ES
dc.contributor.author Martínez Díaz, S. es_ES
dc.contributor.author Garcia Giralt, Natalia es_ES
dc.contributor.author Torres Claramunt, R. es_ES
dc.contributor.author Gómez-Tejedor, José Antonio es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.contributor.author Vila Canet, G es_ES
dc.contributor.author Monllau, J.C. es_ES
dc.date.accessioned 2017-07-20T11:19:43Z
dc.date.available 2017-07-20T11:19:43Z
dc.date.issued 2014-05
dc.identifier.issn 0885-3282
dc.identifier.uri http://hdl.handle.net/10251/85547
dc.description.abstract Polycaprolactone scaffolds modified with cross-linked hyaluronic acid were prepared in order to establish whether a more hydrophilic and biomimetic microenvironment benefits the progenitor cells arriving from bone marrow in a cell- free tissue-engineering approach. The polycaprolactone and polycaprolactone/hyaluronic acid scaffolds were characterized in terms of morphology and water absorption capacity. The polycaprolactone and polycaprolactone/hyaluronic acid samples were implanted in a chondral defect in rabbits; bleeding of the subchondral bone was provoked to generate a spontaneous healing response. Repair at 1, 4, 12, and 24 weeks was assessed macroscopically using the International Cartilage Repair Society score and the Oswestry Arthroscopy Score and microscopically using immunohistological staining for collagen type I and type II, and for Ki-67. The presence of hyaluronic acid improves scaffold performance, which supports a good repair response without biomaterial pre-seeding. es_ES
dc.description.sponsorship JLGR, JAGT and JCM acknowledge the support of the Spanish Ministry of Science through projects No. MAT2010-21611-C03-01 and -02. The support of Grant 2005SGR 00762 and 2005SGR 00848 (Catalan Department of Universities, Research and the Information Society) and the Red Tematica de Investigacion Cooperativa en Envejecimiento y Fragilidad (RETICEF) is also acknowledged. Myriam Lebourg acknowledges funding from UPV through the PAID-10 project funds and from CIBER-BBN. CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. en_EN
dc.language Inglés es_ES
dc.publisher SAGE Publications (UK and US) es_ES
dc.relation.ispartof Journal of Biomaterials Applications es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Cell-free PCL scaffold es_ES
dc.subject Cartilage regeneration es_ES
dc.subject Hyaluronic acid es_ES
dc.subject Osteoarthritis es_ES
dc.subject Tissue engineering es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Cell-free cartilage engineering approach using hyaluronic acid-polycaprolactone scaffolds: A study invivo es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1177/0885328213507298
dc.relation.projectID info:eu-repo/grantAgreement/UPV//PAID-06-10/
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//MAT2010-21611-C03-01/ES/MATERIALES BIOESTABLES Y BIOREABSORBIBLES A LARGO PLAZO COMO SOPORTES MACROPOROSOS PARA LA REGENERACION DEL CARTILAGO ARTICULAR/
dc.relation.projectID info:eu-repo/grantAgreement/GC//2005SGR-00848/
dc.relation.projectID info:eu-repo/grantAgreement/GC//2005SGR-00762/
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny es_ES
dc.description.bibliographicCitation Lebourg, MM.; Martínez Díaz, S.; Garcia Giralt, N.; Torres Claramunt, R.; Gómez-Tejedor, JA.; Gómez Ribelles, JL.; Vila Canet, G.... (2014). Cell-free cartilage engineering approach using hyaluronic acid-polycaprolactone scaffolds: A study invivo. Journal of Biomaterials Applications. 28(9):1304-1315. https://doi.org/10.1177/0885328213507298 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1177/0885328213507298 es_ES
dc.description.upvformatpinicio 1304 es_ES
dc.description.upvformatpfin 1315 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 28 es_ES
dc.description.issue 9 es_ES
dc.relation.senia 282362 es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación
dc.contributor.funder Generalitat de Catalunya
dc.contributor.funder Red Tematica de Investigacion Cooperativa en Envejecimiento y Fragilidad
dc.contributor.funder Universitat Politècnica de València
dc.contributor.funder Instituto de Salud Carlos III
dc.contributor.funder European Regional Development Fund
dc.contributor.funder Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina es_ES
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