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Effect of ischemic postconditioning on microvascular obstruction in reperfused myocardial infarction. Results of a randomized study in patients and of an experimental model in swine

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Effect of ischemic postconditioning on microvascular obstruction in reperfused myocardial infarction. Results of a randomized study in patients and of an experimental model in swine

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dc.contributor.author Bodí, Vicente es_ES
dc.contributor.author Ruiz Nodar, Juan M. es_ES
dc.contributor.author Feliu, Eloisa es_ES
dc.contributor.author Minana, Gema es_ES
dc.contributor.author Nuñez, Julio es_ES
dc.contributor.author Husser, Oliver es_ES
dc.contributor.author Martinez Elvira, Javier es_ES
dc.contributor.author Ruiz, Amparo es_ES
dc.contributor.author Bonanad, Clara es_ES
dc.contributor.author Monmeneu, Jose V. es_ES
dc.contributor.author López Lereu, María Pilar es_ES
dc.contributor.author Forteza, Maria J. es_ES
dc.contributor.author De Dios, Elena es_ES
dc.contributor.author Hervas, Arantxa es_ES
dc.contributor.author Moratal Pérez, David es_ES
dc.contributor.author Gomez, Cristina es_ES
dc.contributor.author Mainar, Luis es_ES
dc.contributor.author Sanchis, Juan es_ES
dc.contributor.author Mainar, Vicente es_ES
dc.contributor.author Valencia, Jose es_ES
dc.contributor.author Diaz, Ana es_ES
dc.contributor.author Noguera, Inmaculada es_ES
dc.contributor.author Chaustre Mendoza, Luis Fabián es_ES
dc.contributor.author Chorro, Francisco J. es_ES
dc.date.accessioned 2017-07-24T12:35:04Z
dc.date.available 2017-07-24T12:35:04Z
dc.date.issued 2014-07-15
dc.identifier.issn 0167-5273
dc.identifier.uri http://hdl.handle.net/10251/85658
dc.description.abstract Background: Ischemic postconditioning (PCON) appears as a potentially beneficial tool in ST-segment elevation myocardial infarction (STEMI). We evaluated the effect of PCON on microvascular obstruction (MVO) in STEMI patients and in an experimental swine model. Methods: A prospective randomized study in patients and an experimental study in swine were carried out in two university hospitals in Spain. 101 consecutive STEMI patients were randomized to undergo primary angio-plasty followed by PCON or primary angioplasty alone (non-PCON). Using late gadolinium enhancement cardiovascular magnetic resonance, infarct size and MVO were quantified (% of left ventricular mass). In swine, using an angioplasty balloon-induced anterior STEMI model, MVO was defined as the % of area at risk without thioflavin-S staining. Results: In patients, PCON (n = 49) in comparison with non-PCON (n = 52) did not significantly reduce MVO (0 [0-1.02]% vs. 0 [0-2.1]% p = 0.2) or IS (18 +/- 13% vs. 21 +/- 14%, p = 0.2). MVO (>1 segment in the 17-segment model) occurred in 12/49 (25%) PCON and in 18/52 (35%) non-PCON patients, p = 0.3. No significant differences were observed between PCON and non-PCON patients in left ventricular volumes, ejection fraction or the extent of hemorrhage. In the swine model, MVO occurred in 4/6 (67%) PCON and in 4/6 (67%) non-PCON pigs, p = 0.9. The extent of MVO (10 +/- 7% vs. 10 +/- 8%, p = 0.9) and infarct size (23 +/- 14% vs. 24 +/- 10%, p = 0.8) was not reduced in PCON compared with non-PCON pigs. Conclusions: Ischemic postconditioning does not significantly reduce microvascular obstruction in ST-segment elevation myocardial infarction. es_ES
dc.description.sponsorship The present study was supported by the "Instituto de Salud Carlos III" (PI1102323 grant), FEDER, the "Conselleria de Educacio, Cultura i Esport de la Generalitat Valenciana" (PROMETEO/2013/007 grant) and by the Regensburger Forschungsforderung in der Medizin (ReForM). en_EN
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof International Journal of Cardiology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Myocardial infarction es_ES
dc.subject Perfusion es_ES
dc.subject Ischemic postconditioning es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Effect of ischemic postconditioning on microvascular obstruction in reperfused myocardial infarction. Results of a randomized study in patients and of an experimental model in swine es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.ijcard.2014.05.003
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//PI11%2F02323/ES/La metabolómica en el diagnóstico y el pronóstico de las enfermedades cardiovasculares. Una aproximación traslacional/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2013%2F007/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular es_ES
dc.description.bibliographicCitation Bodí, V.; Ruiz Nodar, JM.; Feliu, E.; Minana, G.; Nuñez, J.; Husser, O.; Martinez Elvira, J.... (2014). Effect of ischemic postconditioning on microvascular obstruction in reperfused myocardial infarction. Results of a randomized study in patients and of an experimental model in swine. International Journal of Cardiology. 175(1):138-146. https://doi.org/10.1016/j.ijcard.2014.05.003 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.1016/j.ijcard.2014.05.003 es_ES
dc.description.upvformatpinicio 138 es_ES
dc.description.upvformatpfin 146 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 175 es_ES
dc.description.issue 1 es_ES
dc.relation.senia 279483 es_ES
dc.identifier.eissn 1874-1754
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Universität Regensburg es_ES
dc.contributor.funder European Regional Development Fund es_ES


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