Bodí, V.; Ruiz Nodar, JM.; Feliu, E.; Minana, G.; Nuñez, J.; Husser, O.; Martinez Elvira, J.... (2014). Effect of ischemic postconditioning on microvascular obstruction in reperfused myocardial infarction. Results of a randomized study in patients and of an experimental model in swine. International Journal of Cardiology. 175(1):138-146. https://doi.org/10.1016/j.ijcard.2014.05.003
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/85658
Título:
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Effect of ischemic postconditioning on microvascular obstruction in reperfused myocardial infarction. Results of a randomized study in patients and of an experimental model in swine
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Autor:
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Bodí, Vicente
Ruiz Nodar, Juan M.
Feliu, Eloisa
Minana, Gema
Nuñez, Julio
Husser, Oliver
Martinez Elvira, Javier
Ruiz, Amparo
Bonanad, Clara
Monmeneu, Jose V.
López Lereu, María Pilar
Forteza, Maria J.
De Dios, Elena
Hervas, Arantxa
Moratal Pérez, David
Gomez, Cristina
Mainar, Luis
Sanchis, Juan
Mainar, Vicente
Valencia, Jose
Diaz, Ana
Noguera, Inmaculada
Chaustre Mendoza, Luis Fabián
Chorro, Francisco J.
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Entidad UPV:
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Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica
Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular
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Fecha difusión:
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Resumen:
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Background: Ischemic postconditioning (PCON) appears as a potentially beneficial tool in ST-segment elevation myocardial infarction (STEMI). We evaluated the effect of PCON on microvascular obstruction (MVO) in STEMI ...[+]
Background: Ischemic postconditioning (PCON) appears as a potentially beneficial tool in ST-segment elevation myocardial infarction (STEMI). We evaluated the effect of PCON on microvascular obstruction (MVO) in STEMI patients and in an experimental swine model.
Methods: A prospective randomized study in patients and an experimental study in swine were carried out in two university hospitals in Spain. 101 consecutive STEMI patients were randomized to undergo primary angio-plasty followed by PCON or primary angioplasty alone (non-PCON). Using late gadolinium enhancement cardiovascular magnetic resonance, infarct size and MVO were quantified (% of left ventricular mass). In swine, using an angioplasty balloon-induced anterior STEMI model, MVO was defined as the % of area at risk without thioflavin-S staining.
Results: In patients, PCON (n = 49) in comparison with non-PCON (n = 52) did not significantly reduce MVO (0 [0-1.02]% vs. 0 [0-2.1]% p = 0.2) or IS (18 +/- 13% vs. 21 +/- 14%, p = 0.2). MVO (>1 segment in the 17-segment model) occurred in 12/49 (25%) PCON and in 18/52 (35%) non-PCON patients, p = 0.3. No significant differences were observed between PCON and non-PCON patients in left ventricular volumes, ejection fraction or the extent of hemorrhage. In the swine model, MVO occurred in 4/6 (67%) PCON and in 4/6 (67%) non-PCON pigs, p = 0.9. The extent of MVO (10 +/- 7% vs. 10 +/- 8%, p = 0.9) and infarct size (23 +/- 14% vs. 24 +/- 10%, p = 0.8) was not reduced in PCON compared with non-PCON pigs.
Conclusions: Ischemic postconditioning does not significantly reduce microvascular obstruction in ST-segment elevation myocardial infarction.
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Palabras clave:
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Myocardial infarction
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Perfusion
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Ischemic postconditioning
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Derechos de uso:
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Cerrado |
Fuente:
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International Journal of Cardiology. (issn:
0167-5273
) (eissn:
1874-1754
)
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DOI:
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10.1016/j.ijcard.2014.05.003
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Editorial:
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Elsevier
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Versión del editor:
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http://doi.org/10.1016/j.ijcard.2014.05.003
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Código del Proyecto:
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info:eu-repo/grantAgreement/MICINN//PI11%2F02323/ES/La metabolómica en el diagnóstico y el pronóstico de las enfermedades cardiovasculares. Una aproximación traslacional/
info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2013%2F007/
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Agradecimientos:
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The present study was supported by the "Instituto de Salud Carlos III" (PI1102323 grant), FEDER, the "Conselleria de Educacio, Cultura i Esport de la Generalitat Valenciana" (PROMETEO/2013/007 grant) and by the Regensburger ...[+]
The present study was supported by the "Instituto de Salud Carlos III" (PI1102323 grant), FEDER, the "Conselleria de Educacio, Cultura i Esport de la Generalitat Valenciana" (PROMETEO/2013/007 grant) and by the Regensburger Forschungsforderung in der Medizin (ReForM).
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Tipo:
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Artículo
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