López Hernandez, M.; Morejon Alonso, L.; Monleón Pradas, M.; Ledea Lozano, OE.; Guadarrama Bello, D. (2013). Composites of poly(methyl methacrylate) with hybrid fillers (micro/nanohydroxyapatite): mechanical, setting properties, bioactivity and cytotoxicity in vitro. Polymer Composites. 34(11):1927-1937. doi:10.1002/pc.22600
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/87882
Title:
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Composites of poly(methyl methacrylate) with hybrid fillers (micro/nanohydroxyapatite): mechanical, setting properties, bioactivity and cytotoxicity in vitro
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Author:
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López Hernandez, Mónica
Morejon Alonso, Lizette
Monleón Pradas, Manuel
Ledea Lozano, Oscar Ernesto
Guadarrama Bello, Dainelys
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UPV Unit:
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Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials
Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular
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Issued date:
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Abstract:
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[EN] Novel composites of poly(methyl methacrylate) with silanized micro and nanohydroxyapatite (HA) particles were prepared. Coralina((R)) HA was the MicroHA filler and synthetic NanoHA was the reinforcement. The influence ...[+]
[EN] Novel composites of poly(methyl methacrylate) with silanized micro and nanohydroxyapatite (HA) particles were prepared. Coralina((R)) HA was the MicroHA filler and synthetic NanoHA was the reinforcement. The influence of the total inorganic content and the proportion of micro- to NanoHA on the setting properties (i.e., setting time and peak polymerization temperature), compressive strength, and in vitro bioactivity in simulated body fluid (SBF) was analyzed. The novel composites exhibited appropriate handling properties. Compressive strength ranged between 71.30 +/- 0.04 and 80.0 +/- 2.4 MPa. The peak polymerization temperatures varied from 44.5 +/- 0.5 to 50.8 +/- 1.8 degrees C, and thus complying with the ISO 5833 standard. The composites exhibited excellent calcium phosphate deposition in SBF and those with 30 wt% inorganic content showed no cytotoxicity on L929 fibroblastic cells. These results encourage further testing of these novel composites for potential future use in human health applications. POLYM. COMPOS., 34:1927-1937, 2013.
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Subjects:
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ACRYLIC BONE-CEMENT
,
FUNCTIONALIZED METHACRYLATES
,
NANO-HYDROXYAPATITE
,
CERAMIC FILLERS
,
PMMA
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PARTICLES
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INVIVO
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POWDER
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VIVO
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TCP
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Copyrigths:
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Cerrado |
Source:
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Polymer Composites. (issn:
0272-8397
) (eissn:
1548-0569
)
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DOI:
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10.1002/pc.22600
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Publisher:
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Wiley
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Publisher version:
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http://dx.doi. org/10.1002/pc.22600
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Project ID:
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MAEC-AECID
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Thanks:
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Contract grant sponsor: MAEC-AECID.
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Type:
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Artículo
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