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Composites of poly(methyl methacrylate) with hybrid fillers (micro/nanohydroxyapatite): mechanical, setting properties, bioactivity and cytotoxicity in vitro

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Composites of poly(methyl methacrylate) with hybrid fillers (micro/nanohydroxyapatite): mechanical, setting properties, bioactivity and cytotoxicity in vitro

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dc.contributor.author López Hernandez, Mónica es_ES
dc.contributor.author Morejon Alonso, Lizette es_ES
dc.contributor.author Monleón Pradas, Manuel es_ES
dc.contributor.author Ledea Lozano, Oscar Ernesto es_ES
dc.contributor.author Guadarrama Bello, Dainelys es_ES
dc.date.accessioned 2017-09-25T07:08:01Z
dc.date.available 2017-09-25T07:08:01Z
dc.date.issued 2013-11
dc.identifier.issn 0272-8397
dc.identifier.uri http://hdl.handle.net/10251/87882
dc.description.abstract [EN] Novel composites of poly(methyl methacrylate) with silanized micro and nanohydroxyapatite (HA) particles were prepared. Coralina((R)) HA was the MicroHA filler and synthetic NanoHA was the reinforcement. The influence of the total inorganic content and the proportion of micro- to NanoHA on the setting properties (i.e., setting time and peak polymerization temperature), compressive strength, and in vitro bioactivity in simulated body fluid (SBF) was analyzed. The novel composites exhibited appropriate handling properties. Compressive strength ranged between 71.30 +/- 0.04 and 80.0 +/- 2.4 MPa. The peak polymerization temperatures varied from 44.5 +/- 0.5 to 50.8 +/- 1.8 degrees C, and thus complying with the ISO 5833 standard. The composites exhibited excellent calcium phosphate deposition in SBF and those with 30 wt% inorganic content showed no cytotoxicity on L929 fibroblastic cells. These results encourage further testing of these novel composites for potential future use in human health applications. POLYM. COMPOS., 34:1927-1937, 2013. es_ES
dc.description.sponsorship Contract grant sponsor: MAEC-AECID. en_EN
dc.language Inglés es_ES
dc.publisher Wiley es_ES
dc.relation.ispartof Polymer Composites es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject ACRYLIC BONE-CEMENT es_ES
dc.subject FUNCTIONALIZED METHACRYLATES es_ES
dc.subject NANO-HYDROXYAPATITE es_ES
dc.subject CERAMIC FILLERS es_ES
dc.subject PMMA es_ES
dc.subject PARTICLES es_ES
dc.subject INVIVO es_ES
dc.subject POWDER es_ES
dc.subject VIVO es_ES
dc.subject TCP es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Composites of poly(methyl methacrylate) with hybrid fillers (micro/nanohydroxyapatite): mechanical, setting properties, bioactivity and cytotoxicity in vitro es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/pc.22600
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular es_ES
dc.description.bibliographicCitation López Hernandez, M.; Morejon Alonso, L.; Monleón Pradas, M.; Ledea Lozano, OE.; Guadarrama Bello, D. (2013). Composites of poly(methyl methacrylate) with hybrid fillers (micro/nanohydroxyapatite): mechanical, setting properties, bioactivity and cytotoxicity in vitro. Polymer Composites. 34(11):1927-1937. doi:10.1002/pc.22600 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi. org/10.1002/pc.22600 es_ES
dc.description.upvformatpinicio 1927 es_ES
dc.description.upvformatpfin 1937 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 34 es_ES
dc.description.issue 11 es_ES
dc.relation.senia 262577 es_ES
dc.identifier.eissn 1548-0569
dc.contributor.funder Ministerio de Asuntos Exteriores y Cooperación es_ES
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